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G6pdx glucose-6-phosphate dehydrogenase X-linked [ Mus musculus (house mouse) ]

Gene ID: 14381, updated on 18-Sep-2024

Summary

Official Symbol
G6pdxprovided by MGI
Official Full Name
glucose-6-phosphate dehydrogenase X-linkedprovided by MGI
Primary source
MGI:MGI:105979
See related
Ensembl:ENSMUSG00000031400 AllianceGenome:MGI:105979
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
G28A; G6pd; Gpdx
Summary
Enables glucose-6-phosphate dehydrogenase activity and identical protein binding activity. Acts upstream of or within several processes, including NADP biosynthetic process; erythrocyte development; and maintenance of blood vessel diameter homeostasis by renin-angiotensin. Predicted to be located in several cellular components, including centriolar satellite; cytoplasmic side of plasma membrane; and cytosol. Is expressed in several structures, including adipose tissue; genitourinary system; immune system; liver; and mammary gland. Used to study favism. Human ortholog(s) of this gene implicated in several diseases, including anemia (multiple); cerebrovascular disease; favism; malaria (multiple); and neonatal jaundice. Orthologous to human G6PD (glucose-6-phosphate dehydrogenase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in subcutaneous fat pad adult (RPKM 89.0), genital fat pad adult (RPKM 75.9) and 26 other tissues See more
Orthologs
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Genomic context

See G6pdx in Genome Data Viewer
Location:
X A7.3; X 38.0 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (73453089..73472486, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (74409483..74428880, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene predicted readthrough transcript (NMD candidate), 44504 Neighboring gene solute carrier family 10 (sodium/bile acid cotransporter family), member 3 Neighboring gene FAM3 metabolism regulating signaling molecule A Neighboring gene STARR-seq mESC enhancer starr_47367 Neighboring gene inhibitor of kappaB kinase gamma Neighboring gene STARR-positive B cell enhancer ABC_E11050 Neighboring gene predicted gene, 54057 Neighboring gene CTAG2 like 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (1) 
  • Endonuclease-mediated (1) 
  • Radiation induced (1)  1 citation
  • Targeted (1)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables D-glucose binding ISO
Inferred from Sequence Orthology
more info
 
enables NADP binding IEA
Inferred from Electronic Annotation
more info
 
enables NADP binding ISO
Inferred from Sequence Orthology
more info
 
enables carbohydrate binding ISO
Inferred from Sequence Orthology
more info
 
enables glucose-6-phosphate dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables glucose-6-phosphate dehydrogenase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables glucose-6-phosphate dehydrogenase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables glucose-6-phosphate dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within NADP biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within NADP biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in NADP metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in NADP metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in NADPH regeneration ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within angiotensin-mediated vasodilation involved in regulation of systemic arterial blood pressure IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to oxidative stress ISO
Inferred from Sequence Orthology
more info
 
involved_in cholesterol biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cytokine production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within erythrocyte development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in erythrocyte maturation ISO
Inferred from Sequence Orthology
more info
 
involved_in glucose 6-phosphate metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in glucose 6-phosphate metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in glucose metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in glucose metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within glutathione metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in glutathione metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within interleukin-10 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within interleukin-12 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cell growth involved in cardiac muscle cell development ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein glutathionylation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of reactive oxygen species metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within pentose biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within pentose biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in pentose biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in pentose-phosphate shunt ISO
Inferred from Sequence Orthology
more info
 
involved_in pentose-phosphate shunt, oxidative branch IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in pentose-phosphate shunt, oxidative branch IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in pentose-phosphate shunt, oxidative branch ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in response to ethanol ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ribose phosphate biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in centriolar satellite ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
glucose-6-phosphate 1-dehydrogenase X
NP_032088.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008062.3NP_032088.1  glucose-6-phosphate 1-dehydrogenase X

    See identical proteins and their annotated locations for NP_032088.1

    Status: VALIDATED

    Source sequence(s)
    AW489257, BC075663
    Consensus CDS
    CCDS30232.1
    UniProtKB/Swiss-Prot
    Q00612
    UniProtKB/TrEMBL
    Q3TNL1, Q790Y8
    Related
    ENSMUSP00000004327.5, ENSMUST00000004327.11
    Conserved Domains (3) summary
    TIGR00871
    Location:30506
    zwf; glucose-6-phosphate 1-dehydrogenase
    pfam00479
    Location:35209
    G6PD_N; Glucose-6-phosphate dehydrogenase, NAD binding domain
    pfam02781
    Location:212503
    G6PD_C; Glucose-6-phosphate dehydrogenase, C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    73453089..73472486 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)