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G6pc2 glucose-6-phosphatase, catalytic, 2 [ Mus musculus (house mouse) ]

Gene ID: 14378, updated on 17-Jun-2024

Summary

Official Symbol
G6pc2provided by MGI
Official Full Name
glucose-6-phosphatase, catalytic, 2provided by MGI
Primary source
MGI:MGI:1277193
See related
Ensembl:ENSMUSG00000005232 AllianceGenome:MGI:1277193
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
IGRP; G6pc-rs
Summary
This gene encodes an enzyme that belongs to the glucose-6-phosphatase catalytic subunit family. Members of this family catalyze the hydrolysis of glucose-6-phosphate, the terminal step in gluconeogenic and glycogenolytic pathways, to release glucose into the bloodstream. The family member encoded by this gene is found specifically in pancreatic islets but has not been shown to have phosphotransferase or phosphatase activity exhibited by a similar liver enzyme. The non-obese diabetic (NOD) mouse is a model for human type 1 diabetes, an autoimmune disease in which T lymphocytes attack and destroy insulin-producing pancreatic beta cells. In NOD mice, the protein encoded by this gene is a major target of cell-mediated autoimmunity. Variations in the human and mouse genes are associated with lower fasting plasma glucose levels. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See G6pc2 in Genome Data Viewer
Location:
2 C2; 2 39.66 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (69041417..69058337)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (69211073..69227993)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_04727 Neighboring gene predicted gene, 39840 Neighboring gene nitric oxide synthase trafficker Neighboring gene STARR-positive B cell enhancer ABC_E412 Neighboring gene SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae) Neighboring gene STARR-seq mESC enhancer starr_04729 Neighboring gene ATP-binding cassette, sub-family B member 11 Neighboring gene STARR-seq mESC enhancer starr_04731 Neighboring gene STARR-seq mESC enhancer starr_04732 Neighboring gene predicted gene, 36393 Neighboring gene dehydrogenase/reductase 9

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (3)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables glucose-6-phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables glucose-6-phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables glucose-6-phosphatase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables glucose-6-phosphatase activity ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in gluconeogenesis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in glucose 6-phosphate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in glucose homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of insulin secretion ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 
located_in endoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
glucose-6-phosphatase 2
Names
G-6-Pase 2
glucose-6-phosphatase, catalytic, related sequence
islet-specific glucose-6-phosphatase catalytic subunit-related protein
NP_001276785.1
NP_001276786.1
NP_067306.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289856.1NP_001276785.1  glucose-6-phosphatase 2 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' terminal exon, lacks a portion of the 5' coding region and initiates translation at a downstream start codon compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AK148465, BP758187, BQ557220
    UniProtKB/Swiss-Prot
    Q9Z186
    Conserved Domains (1) summary
    cl00474
    Location:1162
    PAP2_like; PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid ...
  2. NM_001289857.1NP_001276786.1  glucose-6-phosphatase 2 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR and lacks an alternate exon in the coding region resulting in a frameshift and an early stop codon compared to variant 1. The encoded isoform (3) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AK148450, BP758187
    Consensus CDS
    CCDS71066.1
    UniProtKB/Swiss-Prot
    Q9Z186
    Related
    ENSMUSP00000107936.3, ENSMUST00000112317.3
    Conserved Domains (1) summary
    cl00474
    Location:38138
    PAP2_like; PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid ...
  3. NM_021331.4NP_067306.1  glucose-6-phosphatase 2 isoform 1

    See identical proteins and their annotated locations for NP_067306.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK148450, AK148465, BP758187
    Consensus CDS
    CCDS16089.1
    UniProtKB/Swiss-Prot
    A2AUN2, Q2M2M7, Q9Z186
    Related
    ENSMUSP00000005364.6, ENSMUST00000005364.12
    Conserved Domains (2) summary
    COG0671
    Location:36193
    PgpB; Membrane-associated phospholipid phosphatase [Lipid transport and metabolism]
    cd03381
    Location:38278
    PAP2_glucose_6_phosphatase; PAP2_like proteins, glucose-6-phosphatase subfamily. Glucose-6-phosphatase converts glucose-6-phosphate into free glucose and is active in the lumen of the endoplasmic reticulum, where it is bound to the membrane. The generation of free glucose is an ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    69041417..69058337
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)