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Ganab alpha glucosidase 2 alpha neutral subunit [ Mus musculus (house mouse) ]

Gene ID: 14376, updated on 15-Apr-2019

Summary

Official Symbol
Ganabprovided by MGI
Official Full Name
alpha glucosidase 2 alpha neutral subunitprovided by MGI
Primary source
MGI:MGI:1097667
See related
Ensembl:ENSMUSG00000071650
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
G2an; GluII; AU042638; mKIAA0088
Expression
Ubiquitous expression in limb E14.5 (RPKM 61.9), placenta adult (RPKM 49.8) and 28 other tissues See more
Orthologs

Genomic context

See Ganab in Genome Data Viewer
Location:
19; 19 A
Exon count:
26
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 19 NC_000085.6 (8898057..8916742)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (8972601..8991156)

Chromosome 19 - NC_000085.6Genomic Context describing neighboring genes Neighboring gene LBH domain containing 1 Neighboring gene RIKEN cDNA 1810009A15 gene Neighboring gene integrator complex subunit 5 Neighboring gene predicted gene, 36629 Neighboring gene beta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I) Neighboring gene rod outer segment membrane protein 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC144011, MGC144012

Gene Ontology Provided by MGI

Function Evidence Code Pubs
alpha-glucosidase activity ISO
Inferred from Sequence Orthology
more info
 
carbohydrate binding IEA
Inferred from Electronic Annotation
more info
 
catalytic activity IEA
Inferred from Electronic Annotation
more info
 
glucan 1,3-alpha-glucosidase activity IDA
Inferred from Direct Assay
more info
PubMed 
glucan 1,3-alpha-glucosidase activity ISO
Inferred from Sequence Orthology
more info
 
glucosidase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
hydrolase activity, acting on glycosyl bonds IEA
Inferred from Electronic Annotation
more info
 
hydrolase activity, hydrolyzing O-glycosyl compounds IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
N-glycan processing IDA
Inferred from Direct Assay
more info
PubMed 
N-glycan processing ISO
Inferred from Sequence Orthology
more info
 
N-glycan processing TAS
Traceable Author Statement
more info
PubMed 
carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
 
metabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum TAS
Traceable Author Statement
more info
PubMed 
glucosidase II complex IDA
Inferred from Direct Assay
more info
PubMed 
glucosidase II complex IPI
Inferred from Physical Interaction
more info
PubMed 
glucosidase II complex ISO
Inferred from Sequence Orthology
more info
 
intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
neutral alpha-glucosidase AB
Names
alpha-glucosidase 2
carbohydrate processing enzyme of the endoplasmic reticulum
glucosidase II alpha-subunit
glucosidase II subunit alpha
NP_001280550.1
NP_032086.1
XP_006526740.1
XP_006526741.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001293621.1NP_001280550.1  neutral alpha-glucosidase AB isoform 2 precursor

    See identical proteins and their annotated locations for NP_001280550.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the coding region, compared to variant 1. The encoded protein (isoform 2) is shorter, compared to isoform 1.
    Source sequence(s)
    AC129217, AK081915, BB002622, BC094437
    UniProtKB/Swiss-Prot
    Q8BHN3
    Related
    ENSMUSP00000158122.1, ENSMUST00000235274.1
    Conserved Domains (3) summary
    cd06603
    Location:384851
    GH31_GANC_GANAB_alpha; neutral alpha-glucosidase C, neutral alpha-glucosidase AB
    cd14752
    Location:242384
    GH31_N; N-terminal domain of glycosyl hydrolase family 31 (GH31)
    pfam01055
    Location:365810
    Glyco_hydro_31; Glycosyl hydrolases family 31
  2. NM_008060.2NP_032086.1  neutral alpha-glucosidase AB isoform 1

    See identical proteins and their annotated locations for NP_032086.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC129217, AK030722, AK081915, BB002622, BC128069
    Consensus CDS
    CCDS29557.1
    UniProtKB/Swiss-Prot
    Q8BHN3
    UniProtKB/TrEMBL
    A1A4T2
    Related
    ENSMUSP00000093965.3, ENSMUST00000096246.4
    Conserved Domains (3) summary
    cd06603
    Location:406873
    GH31_GANC_GANAB_alpha; neutral alpha-glucosidase C, neutral alpha-glucosidase AB
    cd14752
    Location:264406
    GH31_N; N-terminal domain of glycosyl hydrolase family 31 (GH31)
    pfam01055
    Location:387832
    Glyco_hydro_31; Glycosyl hydrolases family 31

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000085.6 Reference GRCm38.p4 C57BL/6J

    Range
    8898057..8916742
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006526677.2XP_006526740.1  neutral alpha-glucosidase AB isoform X1

    Conserved Domains (3) summary
    cd06603
    Location:309776
    GH31_GANC_GANAB_alpha; neutral alpha-glucosidase C, neutral alpha-glucosidase AB
    cd14752
    Location:167309
    GH31_N; N-terminal domain of glycosyl hydrolase family 31 (GH31)
    pfam01055
    Location:290735
    Glyco_hydro_31; Glycosyl hydrolases family 31
  2. XM_006526678.2XP_006526741.1  neutral alpha-glucosidase AB isoform X2

    Conserved Domains (3) summary
    cd06603
    Location:287754
    GH31_GANC_GANAB_alpha; neutral alpha-glucosidase C, neutral alpha-glucosidase AB
    cd14752
    Location:145287
    GH31_N; N-terminal domain of glycosyl hydrolase family 31 (GH31)
    pfam01055
    Location:268713
    Glyco_hydro_31; Glycosyl hydrolases family 31
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