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PIWIL4 piwi like RNA-mediated gene silencing 4 [ Homo sapiens (human) ]

Gene ID: 143689, updated on 26-Nov-2021

Summary

Official Symbol
PIWIL4provided by HGNC
Official Full Name
piwi like RNA-mediated gene silencing 4provided by HGNC
Primary source
HGNC:HGNC:18444
See related
Ensembl:ENSG00000134627 MIM:610315
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HIWI2; MIWI2
Summary
PIWIL4 belongs to the Argonaute family of proteins, which function in development and maintenance of germline stem cells (Sasaki et al., 2003 [PubMed 12906857]).[supplied by OMIM, Mar 2008]
Expression
Broad expression in bone marrow (RPKM 9.2), testis (RPKM 8.7) and 19 other tissues See more
Orthologs
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Genomic context

See PIWIL4 in Genome Data Viewer
Location:
11q21
Exon count:
20
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (94567368..94621421)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (94300534..94354587)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene MRE11 homolog, double strand break repair nuclease Neighboring gene chromosome 11 open reading frame 97 Neighboring gene PIWIL4 antisense RNA 1 Neighboring gene fucosyltransferase 4 Neighboring gene long intergenic non-protein coding RNA 2700 Neighboring gene angiomotin like 1 Neighboring gene uncharacterized LOC107984376

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Does parental expressed emotion moderate genetic effects in ADHD? An exploration using a genome wide association scan.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ36156, DKFZp686P01248

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NOT enables endoribonuclease activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables piRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables piRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables piRNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in DNA methylation involved in gamete generation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in epithelial structure maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in gene silencing by RNA IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in gene silencing by RNA ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of transposition ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in piRNA metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of translation IEA
Inferred from Electronic Annotation
more info
 
involved_in spermatogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
is_active_in P granule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in P granule ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in piP-body ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
piwi-like protein 4
Names
piwi-like 4
testis tissue sperm-binding protein Li 85P

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_152431.3NP_689644.2  piwi-like protein 4

    See identical proteins and their annotated locations for NP_689644.2

    Status: VALIDATED

    Source sequence(s)
    AB079366, BC031060, DB091271
    Consensus CDS
    CCDS31656.1
    UniProtKB/Swiss-Prot
    Q7Z3Z4
    UniProtKB/TrEMBL
    A0A140VKG8
    Related
    ENSP00000299001.6, ENST00000299001.11
    Conserved Domains (2) summary
    cd02845
    Location:270386
    PAZ_piwi_like; PAZ domain, Piwi_like subfamily. In multi-cellular organisms, the Piwi protein appears to be essential for the maintenance of germline stem cells. In the Drosophila male germline, Piwi was shown to be involved in the silencing of retrotransposons in the ...
    cd04658
    Location:394835
    Piwi_piwi-like_Euk; Piwi_piwi-like_Euk: PIWI domain, Piwi-like subfamily found in eukaryotes. This domain is found in Piwi and closely related proteins, where it is believed to perform a crucial role in germline cells, via RNA silencing. RNA silencing refers to a group of ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    94567368..94621421
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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