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Fzd4 frizzled class receptor 4 [ Mus musculus (house mouse) ]

Gene ID: 14366, updated on 5-Jan-2022

Summary

Official Symbol
Fzd4provided by MGI
Official Full Name
frizzled class receptor 4provided by MGI
Primary source
MGI:MGI:108520
See related
Ensembl:ENSMUSG00000049791
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fz4
Summary
Enables Wnt-activated receptor activity; Wnt-protein binding activity; and cytokine binding activity. Involved in several processes, including cell surface receptor signaling pathway involved in cell-cell signaling; regulation of transcription, DNA-templated; and vasculature development. Acts upstream of or within several processes, including cellular response to leukemia inhibitory factor; regulation of signal transduction; and vasculature development. Located in several cellular components, including cell-cell junction; dendrite; and glutamatergic synapse. Is expressed in several structures, including alimentary system; branchial arch; genitourinary system; nervous system; and sensory organ. Used to study Norrie disease and exudative vitreoretinopathy. Human ortholog(s) of this gene implicated in exudative vitreoretinopathy 1. Orthologous to human FZD4 (frizzled class receptor 4). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Broad expression in subcutaneous fat pad adult (RPKM 32.3), genital fat pad adult (RPKM 28.0) and 16 other tissues See more
Orthologs
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Genomic context

See Fzd4 in Genome Data Viewer
Location:
7 D3; 7 49.32 cM
Exon count:
3
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (89053574..89062341)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (89404366..89410110)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (96552876..96558620)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene predicted gene 6240 Neighboring gene transmembrane protein 135 Neighboring gene expressed sequence AI314278 Neighboring gene protease, serine 23

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables PDZ domain binding ISO
Inferred from Sequence Orthology
more info
 
enables Wnt-activated receptor activity IPI
Inferred from Physical Interaction
more info
PubMed 
enables Wnt-activated receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables Wnt-protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables Wnt-protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables Wnt-protein binding ISO
Inferred from Sequence Orthology
more info
 
enables amyloid-beta binding ISO
Inferred from Sequence Orthology
more info
 
enables cytokine binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables cytokine binding ISO
Inferred from Sequence Orthology
more info
 
enables cytokine receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor activity IGI
Inferred from Genetic Interaction
more info
PubMed 
enables signaling receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in Norrin signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in Norrin signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in Wnt signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in Wnt signaling pathway, calcium modulating pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within blood vessel development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within canonical Wnt signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in canonical Wnt signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cellular response to leukemia inhibitory factor IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cerebellum vasculature morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in extracellular matrix-cell signaling IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within locomotion involved in locomotory behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within luteinization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of cell-substrate adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cell-substrate adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in non-canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of JUN kinase activity IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neuron projection arborization IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of neuron projection arborization ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within progesterone secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of vascular endothelial growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in retina vasculature morphogenesis in camera-type eye IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within retina vasculature morphogenesis in camera-type eye IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within retina vasculature morphogenesis in camera-type eye IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in retina vasculature morphogenesis in camera-type eye ISO
Inferred from Sequence Orthology
more info
 
involved_in retinal blood vessel morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within sensory perception of sound IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within substrate adhesion-dependent cell spreading IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within vasculogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in cell-cell junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendrite IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
is_active_in synapse IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
frizzled-4
Names
frizzled homolog 4
fz-4
mFz4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008055.4NP_032081.3  frizzled-4 precursor

    See identical proteins and their annotated locations for NP_032081.3

    Status: VALIDATED

    Source sequence(s)
    AK044794, AK049945, CJ171654
    Consensus CDS
    CCDS21441.1
    UniProtKB/Swiss-Prot
    Q61088
    UniProtKB/TrEMBL
    Q3V1B2, Q8BKU9, Q8BLL2
    Related
    ENSMUSP00000049852.4, ENSMUST00000058755.5
    Conserved Domains (2) summary
    cd07448
    Location:42167
    CRD_FZ4; Cysteine-rich Wnt-binding domain of the frizzled 4 (Fz4) receptor
    pfam01534
    Location:210509
    Frizzled; Frizzled/Smoothened family membrane region

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    89053574..89062341
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036152680.1XP_036008573.1  frizzled-4 isoform X1

    Conserved Domains (2) summary
    cd15038
    Location:105405
    7tmF_FZD4; class F frizzled subfamily 4, member of 7-transmembrane G protein-coupled receptors
    cl02447
    Location:163
    CRD_FZ; CRD_domain cysteine-rich domain, also known as Fz (frizzled) domain
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