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Fzd4 frizzled class receptor 4 [ Mus musculus (house mouse) ]

Gene ID: 14366, updated on 30-Dec-2018

Summary

Official Symbol
Fzd4provided by MGI
Official Full Name
frizzled class receptor 4provided by MGI
Primary source
MGI:MGI:108520
See related
Ensembl:ENSMUSG00000049791
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fz4
Expression
Broad expression in subcutaneous fat pad adult (RPKM 32.3), genital fat pad adult (RPKM 28.0) and 16 other tissues See more
Orthologs

Genomic context

See Fzd4 in Genome Data Viewer
Location:
7 D3; 7 49.32 cM
Exon count:
2
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 7 NC_000073.6 (89404366..89410110)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (96552876..96558620)

Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene predicted gene 6240 Neighboring gene transmembrane protein 135 Neighboring gene expressed sequence AI314278 Neighboring gene protease, serine 23, opposite strand Neighboring gene protease, serine 23

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
PDZ domain binding ISO
Inferred from Sequence Orthology
more info
 
Wnt-activated receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Wnt-activated receptor activity IPI
Inferred from Physical Interaction
more info
PubMed 
Wnt-activated receptor activity ISO
Inferred from Sequence Orthology
more info
 
Wnt-protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Wnt-protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Wnt-protein binding ISO
Inferred from Sequence Orthology
more info
 
amyloid-beta binding ISO
Inferred from Sequence Orthology
more info
 
cytokine binding IPI
Inferred from Physical Interaction
more info
PubMed 
cytokine binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
signaling receptor activity IGI
Inferred from Genetic Interaction
more info
PubMed 
signaling receptor activity ISO
Inferred from Sequence Orthology
more info
 
transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
ubiquitin protein ligase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Wnt signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
Wnt signaling pathway, calcium modulating pathway ISO
Inferred from Sequence Orthology
more info
 
blood vessel development IMP
Inferred from Mutant Phenotype
more info
PubMed 
canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
canonical Wnt signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
cellular response to leukemia inhibitory factor IEP
Inferred from Expression Pattern
more info
PubMed 
cerebellum vasculature morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
extracellular matrix-cell signaling IDA
Inferred from Direct Assay
more info
PubMed 
locomotion involved in locomotory behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
luteinization IMP
Inferred from Mutant Phenotype
more info
PubMed 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cell-substrate adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell-substrate adhesion ISO
Inferred from Sequence Orthology
more info
 
non-canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of JUN kinase activity IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of neuron projection arborization IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of neuron projection arborization ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
progesterone secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of vascular endothelial growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
retina vasculature morphogenesis in camera-type eye IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
retina vasculature morphogenesis in camera-type eye IGI
Inferred from Genetic Interaction
more info
PubMed 
retina vasculature morphogenesis in camera-type eye IMP
Inferred from Mutant Phenotype
more info
PubMed 
retina vasculature morphogenesis in camera-type eye ISO
Inferred from Sequence Orthology
more info
 
retinal blood vessel morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
sensory perception of sound IMP
Inferred from Mutant Phenotype
more info
PubMed 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
substrate adhesion-dependent cell spreading IMP
Inferred from Mutant Phenotype
more info
PubMed 
vasculogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cell surface ISO
Inferred from Sequence Orthology
more info
 
cell-cell junction IDA
Inferred from Direct Assay
more info
PubMed 
dendrite IMP
Inferred from Mutant Phenotype
more info
PubMed 
glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
synapse IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
frizzled-4
Names
frizzled homolog 4
fz-4
mFz4

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008055.4NP_032081.3  frizzled-4 precursor

    See identical proteins and their annotated locations for NP_032081.3

    Status: VALIDATED

    Source sequence(s)
    AK044794, AK049945, CJ171654
    Consensus CDS
    CCDS21441.1
    UniProtKB/Swiss-Prot
    Q61088
    UniProtKB/TrEMBL
    Q3V1B2, Q8BKU9, Q8BLL2
    Related
    ENSMUSP00000049852.3, ENSMUST00000058755.4
    Conserved Domains (2) summary
    cd07448
    Location:42167
    CRD_FZ4; Cysteine-rich Wnt-binding domain of the frizzled 4 (Fz4) receptor
    pfam01534
    Location:210509
    Frizzled; Frizzled/Smoothened family membrane region

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000073.6 Reference GRCm38.p4 C57BL/6J

    Range
    89404366..89410110
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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