Format

Send to:

Choose Destination

MUC15 mucin 15, cell surface associated [ Homo sapiens (human) ]

Gene ID: 143662, updated on 19-Sep-2021

Summary

Official Symbol
MUC15provided by HGNC
Official Full Name
mucin 15, cell surface associatedprovided by HGNC
Primary source
HGNC:HGNC:14956
See related
Ensembl:ENSG00000169550 MIM:608566
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PAS3; MUC-15; PASIII
Expression
Biased expression in thyroid (RPKM 49.6), skin (RPKM 13.7) and 5 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See MUC15 in Genome Data Viewer
Location:
11p14.2
Exon count:
5
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (26559032..26572263, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (26580579..26593810, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene anoctamin 3 Neighboring gene ANO3 antisense RNA 1 Neighboring gene uncharacterized LOC105376598 Neighboring gene uncharacterized LOC107987160 Neighboring gene solute carrier family 5 member 12

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Common body mass index-associated variants confer risk of extreme obesity.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi lumen TAS
Traceable Author Statement
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135091.2NP_001128563.1  mucin-15 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AC036114, AY358668, BU676338, DA842986
    Consensus CDS
    CCDS44557.1
    UniProtKB/Swiss-Prot
    Q8N387
    UniProtKB/TrEMBL
    A0A0A0MT67
    Related
    ENSP00000431983.1, ENST00000529533.6
    Conserved Domains (1) summary
    pfam15672
    Location:47361
    Mucin15; Cell-membrane associated Mucin15
  2. NM_001135092.2NP_001128564.1  mucin-15 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The resulting isoform (c) is shorter than isoform a.
    Source sequence(s)
    AC036114, AJ507429, AY358668, BU676338, DA842986
    Consensus CDS
    CCDS44556.1
    UniProtKB/Swiss-Prot
    Q8N387
    UniProtKB/TrEMBL
    A0A0A0MTD6
    Related
    ENSP00000431945.1, ENST00000527569.1
    Conserved Domains (1) summary
    pfam15672
    Location:47311
    Mucin15; Cell-membrane associated Mucin15
  3. NM_145650.4NP_663625.2  mucin-15 isoform b precursor

    See identical proteins and their annotated locations for NP_663625.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and uses a downstream translation initiation codon, compared to variant 1. The resulting isoform (b) is shorter at the N-terminus, compared to isoform a.
    Source sequence(s)
    AC036114, AK128337, AY358668, BU676338, DA842986
    Consensus CDS
    CCDS7859.1
    UniProtKB/Swiss-Prot
    Q8N387
    Related
    ENSP00000397339.2, ENST00000455601.6
    Conserved Domains (1) summary
    pfam15672
    Location:20334
    Mucin15; Cell-membrane associated Mucin15

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    26559032..26572263 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center