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OR52B4 olfactory receptor family 52 subfamily B member 4 [ Homo sapiens (human) ]

Gene ID: 143496, updated on 17-Jun-2024

Summary

Official Symbol
OR52B4provided by HGNC
Official Full Name
olfactory receptor family 52 subfamily B member 4provided by HGNC
Primary source
HGNC:HGNC:15209
See related
Ensembl:ENSG00000221996 AllianceGenome:HGNC:15209
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OR11-3
Summary
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. This olfactory receptor gene is a segregating pseudogene, where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele encoding a protein that is predicted to be non-functional. [provided by RefSeq, Jun 2015]
Annotation information
Note: Genetic polymorphisms result in both protein coding and non-coding alleles of this gene.
Orthologs
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Genomic context

See OR52B4 in Genome Data Viewer
Location:
11p15.4
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (4367263..4368386, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (4432365..4433487, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (4388493..4389616, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene SSU72 like 3 Neighboring gene SSU72 like 1 Neighboring gene olfactory receptor family 52 subfamily B member 3 pseudogene Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr11:4406895-4408094 Neighboring gene tripartite motif containing 21 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4322

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables olfactory receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in cognition IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in detection of chemical stimulus involved in sensory perception of smell IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
olfactory receptor 52B4
Names
olfactory receptor OR11-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001005161.3NP_001005161.2  olfactory receptor 52B4

    See identical proteins and their annotated locations for NP_001005161.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1, coding) represents the protein-coding allele encoded by the GRCh38 reference genome.
    Source sequence(s)
    AC009758
    UniProtKB/Swiss-Prot
    A6NP68, Q6IFK6, Q8NGK2
    UniProtKB/TrEMBL
    A0A126GW82, B2RU22
    Related
    ENSP00000485530.1, ENST00000624801.3
    Conserved Domains (2) summary
    pfam00001
    Location:43294
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:33312
    7tm_4; Olfactory receptor

RNA

  1. NR_178069.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1, non-coding) uses the same exon combination as variant 1, coding, but represents the allele encoded by the T2T-CHM13v2.0 genome assembly. This variant is represented as non-coding because a frameshift in the N-terminus results in a premature stop codon.
    Source sequence(s)
    CP068267

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    4367263..4368386 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    4432365..4433487 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)