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Fut1 fucosyltransferase 1 [ Mus musculus (house mouse) ]

Gene ID: 14343, updated on 26-Sep-2022

Summary

Official Symbol
Fut1provided by MGI
Official Full Name
fucosyltransferase 1provided by MGI
Primary source
MGI:MGI:109375
See related
Ensembl:ENSMUSG00000008461 AllianceGenome:MGI:109375
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MFUT-1
Summary
This gene is one of three genes in mouse which encode a galactoside 2-L-fucosyltransferase. These genes differ in their developmental- and tissue-specific expression. The encoded type II membrane protein is anchored in the Golgi apparatus and controls the final step in the creation of alpha (1,2) fucosylated carbhohydrates by the addition of a terminal fucose in an alpha (1,2) linkage. This enzyme is required for the synthesis of the Lewis antigen as well as the H-antigen, a precursor of the A and B antigens of the ABH histo-blood group. The biological function of the fucosylated carbhohydrate products is thought to involve cell-adhesion and interactions with microorganisms. Disruption of this gene impairs development of the olfactory nerve and maturation of the glomerular layer of the main olfactory bulb. Alternative splicing results in multiple transcript variants which encode distinct isoforms. [provided by RefSeq, Dec 2012]
Expression
Biased expression in genital fat pad adult (RPKM 6.7), testis adult (RPKM 1.0) and 6 other tissues See more
Orthologs
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Genomic context

See Fut1 in Genome Data Viewer
Location:
7 B3; 7 29.39 cM
Exon count:
3
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (45266862..45270483)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (45617606..45621059)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31479 Neighboring gene Fgf21 promoter region Neighboring gene fibroblast growth factor 21 Neighboring gene izumo sperm-egg fusion 1 Neighboring gene Ras interacting protein 1 Neighboring gene RIKEN cDNA A030001D20 gene Neighboring gene MEF2 activating motif and SAP domain containing transcriptional regulator

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Homology

Clone Names

  • MGC129302, MGC129303

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables alpha-(1,2)-fucosyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables fucosyltransferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables galactoside 2-alpha-L-fucosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables galactoside 2-alpha-L-fucosyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in fucosylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within fucosylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in fucosylation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in olfactory bulb development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in oligosaccharide biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cell-matrix adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of endothelial cell-matrix adhesion via fibronectin ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of sprouting angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in protein glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein glycosylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of cell adhesion IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of endothelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in Golgi apparatus IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
galactoside alpha-(1,2)-fucosyltransferase 1
Names
GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 1
H transferase
alpha(1,2)FT 1
beta-galactoside alpha-1,2-fucosyltransferase
galactoside 2-alpha-L-fucosyltransferase 1
type 1 galactoside alpha-(1,2)-fucosyltransferase FUT1
type 2 galactoside alpha-(1,2)-fucosyltransferase FUT1
NP_001258910.1
NP_032077.2
XP_036008571.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271981.1NP_001258910.1  galactoside alpha-(1,2)-fucosyltransferase 1 isoform 2

    See identical proteins and their annotated locations for NP_001258910.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site at the 5' end of the coding exon and uses an in-frame downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC149057, AK137638, BC109145
    Consensus CDS
    CCDS85303.1
    UniProtKB/TrEMBL
    P97327, Q32MG3
    Related
    ENSMUSP00000147274.2, ENSMUST00000209379.2
    Conserved Domains (1) summary
    pfam01531
    Location:18300
    Glyco_transf_11; Glycosyl transferase family 11
  2. NM_008051.6NP_032077.2  galactoside alpha-(1,2)-fucosyltransferase 1 isoform 1

    See identical proteins and their annotated locations for NP_032077.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC149057, AK137638
    Consensus CDS
    CCDS21254.1
    UniProtKB/Swiss-Prot
    P97327
    UniProtKB/TrEMBL
    P97327
    Related
    ENSMUSP00000008605.6, ENSMUST00000008605.6
    Conserved Domains (1) summary
    pfam01531
    Location:39355
    Glyco_transf_11; Glycosyl transferase family 11

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    45266862..45270483
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036152678.1XP_036008571.1  galactoside alpha-(1,2)-fucosyltransferase 1 isoform X1

    UniProtKB/Swiss-Prot
    P97327
    Conserved Domains (1) summary
    pfam01531
    Location:39355
    Glyco_transf_11; Glycosyl transferase family 11