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SYT9 synaptotagmin 9 [ Homo sapiens (human) ]

Gene ID: 143425, updated on 21-Dec-2019

Summary

Official Symbol
SYT9provided by HGNC
Official Full Name
synaptotagmin 9provided by HGNC
Primary source
HGNC:HGNC:19265
See related
Ensembl:ENSG00000170743 MIM:613528
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Biased expression in brain (RPKM 1.0), adrenal (RPKM 0.5) and 7 other tissues See more
Orthologs

Genomic context

See SYT9 in Genome Data Viewer
Location:
11p15.4
Exon count:
12
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (7238784..7470032)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (7273181..7490276)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene NLR family pyrin domain containing 14 Neighboring gene RBMX like 2 Neighboring gene microRNA 302e Neighboring gene uncharacterized LOC100506258 Neighboring gene Sharpr-MPRA regulatory region 13298 Neighboring gene olfactomedin like 1 Neighboring gene PPFIA binding protein 2 Neighboring gene uncharacterized LOC105376535

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

NHGRI GWAS Catalog

Description
Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.
NHGRI GWA Catalog
Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations.
NHGRI GWA Catalog
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ45896

Gene Ontology Provided by GOA

Function Evidence Code Pubs
SNARE binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcium-dependent phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
clathrin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
identical protein binding IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol-4,5-bisphosphate binding IEA
Inferred from Electronic Annotation
more info
 
phosphatidylserine binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
syntaxin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
calcium ion regulated exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcium-dependent activation of synaptic vesicle fusion IEA
Inferred from Electronic Annotation
more info
 
cellular response to calcium ion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
membrane organization TAS
Traceable Author Statement
more info
 
positive regulation of calcium ion-dependent exocytosis IEA
Inferred from Electronic Annotation
more info
 
regulation of calcium ion-dependent exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of dopamine secretion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of insulin secretion IEA
Inferred from Electronic Annotation
more info
 
vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cell junction IEA
Inferred from Electronic Annotation
more info
 
clathrin-coated vesicle membrane TAS
Traceable Author Statement
more info
 
dense core granule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
exocytic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
hippocampal mossy fiber to CA3 synapse IEA
Inferred from Electronic Annotation
more info
 
integral component of synaptic vesicle membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
secretory granule membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
synaptotagmin-9
Names
synaptotagmin IX
sytIX

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_175733.4NP_783860.1  synaptotagmin-9

    See identical proteins and their annotated locations for NP_783860.1

    Status: VALIDATED

    Source sequence(s)
    AC027804, AC060799, AC107884
    Consensus CDS
    CCDS7778.1
    UniProtKB/Swiss-Prot
    Q86SS6
    Related
    ENSP00000324419.6, ENST00000318881.11
    Conserved Domains (2) summary
    cd08403
    Location:354487
    C2B_Synaptotagmin-3-5-6-9-10; C2 domain second repeat present in Synaptotagmins 3, 5, 6, 9, and 10
    cl14603
    Location:221345
    C2; C2 domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    7238784..7470032
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011519902.2XP_011518204.1  synaptotagmin-9 isoform X3

    Conserved Domains (2) summary
    cd08403
    Location:322455
    C2B_Synaptotagmin-3-5-6-9-10; C2 domain second repeat present in Synaptotagmins 3, 5, 6, 9, and 10
    cl14603
    Location:189313
    C2; C2 domain
  2. XM_011519901.2XP_011518203.1  synaptotagmin-9 isoform X2

    Conserved Domains (2) summary
    cd08403
    Location:354487
    C2B_Synaptotagmin-3-5-6-9-10; C2 domain second repeat present in Synaptotagmins 3, 5, 6, 9, and 10
    cl14603
    Location:221345
    C2; C2 domain
  3. XM_011519900.2XP_011518202.1  synaptotagmin-9 isoform X1

    Conserved Domains (2) summary
    cd08403
    Location:354487
    C2B_Synaptotagmin-3-5-6-9-10; C2 domain second repeat present in Synaptotagmins 3, 5, 6, 9, and 10
    cl14603
    Location:221345
    C2; C2 domain
  4. XM_011519904.2XP_011518206.1  synaptotagmin-9 isoform X4

    Conserved Domains (2) summary
    cd08403
    Location:354487
    C2B_Synaptotagmin-3-5-6-9-10; C2 domain second repeat present in Synaptotagmins 3, 5, 6, 9, and 10
    cl14603
    Location:221345
    C2; C2 domain
  5. XM_011519907.2XP_011518209.1  synaptotagmin-9 isoform X6

    Conserved Domains (1) summary
    cl14603
    Location:221345
    C2; C2 domain
  6. XM_011519906.2XP_011518208.1  synaptotagmin-9 isoform X5

    Related
    ENSP00000432141.2, ENST00000524820.6
    Conserved Domains (1) summary
    cl14603
    Location:221345
    C2; C2 domain

RNA

  1. XR_001747773.1 RNA Sequence

  2. XR_001747772.1 RNA Sequence

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