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CACUL1 CDK2 associated cullin domain 1 [ Homo sapiens (human) ]

Gene ID: 143384, updated on 1-Aug-2020

Summary

Official Symbol
CACUL1provided by HGNC
Official Full Name
CDK2 associated cullin domain 1provided by HGNC
Primary source
HGNC:HGNC:23727
See related
Ensembl:ENSG00000151893 MIM:618764
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CAC1; C10orf46
Expression
Ubiquitous expression in testis (RPKM 11.0), bone marrow (RPKM 9.1) and 25 other tissues See more
Orthologs

Genomic context

See CACUL1 in Genome Data Viewer
Location:
10q26.11
Exon count:
9
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (118676411..118754970, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (120433679..120514758, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene prolactin releasing hormone receptor Neighboring gene TOMM22 pseudogene 5 Neighboring gene Sharpr-MPRA regulatory region 11808 Neighboring gene uncharacterized LOC107987151

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ40409, MGC33215

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin protein ligase binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
G1/S transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
CDK2-associated and cullin domain-containing protein 1
Names
Cdk-Associated Cullin1
cdk-associated cullin 1
cullin

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_153810.5NP_722517.3  CDK2-associated and cullin domain-containing protein 1

    See identical proteins and their annotated locations for NP_722517.3

    Status: VALIDATED

    Source sequence(s)
    AJ544771, AL139407, AY743663, BU623607
    Consensus CDS
    CCDS41570.1
    UniProtKB/Swiss-Prot
    Q86Y37
    Related
    ENSP00000358147.2, ENST00000369151.8
    Conserved Domains (1) summary
    pfam00888
    Location:138256
    Cullin; Cullin family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    118676411..118754970 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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