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SPMIP5 sperm microtubule inner protein 5 [ Homo sapiens (human) ]

Gene ID: 143379, updated on 3-Mar-2026
Official Symbol
SPMIP5provided by HGNC
Official Full Name
sperm microtubule inner protein 5provided by HGNC
Primary source
HGNC:HGNC:28500
See related
Ensembl:ENSG00000165863 AllianceGenome:HGNC:28500
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C10orf82
Summary
Predicted to be involved in flagellated sperm motility. Predicted to be located in several cellular components, including cytoskeleton; motile cilium; and nucleus. Predicted to be active in axonemal A tubule inner sheath and sperm flagellum. [provided by Alliance of Genome Resources, Jul 2025]
Expression
Biased expression in testis (RPKM 14.6), ovary (RPKM 2.0) and 1 other tissue See more
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See SPMIP5 in Genome Data Viewer
Location:
10q25.3
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2025_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (116662211..116670282, complement)
RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (117556531..117564614, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (118421722..118429793, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902510 Neighboring gene pancreatic lipase related protein 1 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr10:118393650-118394849 Neighboring gene pancreatic lipase related protein 2 (gene/pseudogene) Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:118405699-118406228 Neighboring gene HSPA12A antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 10762 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:118441833-118442334 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:118442335-118442834 Neighboring gene heat shock protein family A (Hsp70) member 12A Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:118450610-118451348 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:118453631-118454602 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:118501942-118502646 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:118502647-118503350 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:118526330-118526895 Neighboring gene ribosomal protein L5 pseudogene 27 Neighboring gene uncharacterized LOC105378498

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. Structural specializations of the sperm tail. Leung MR, et al. Cell, 2023 Jun 22. PMID 37327785, Free PMC Article
  2. Genome-scale RNAi screen for host factors required for HIV replication. Zhou H, et al. Cell Host Microbe, 2008 Nov 13. PMID 18976975
  3. Towards a proteome-scale map of the human protein-protein interaction network. Rual JF, et al. Nature, 2005 Oct 20. PMID 16189514
  4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. Lamesch P, et al. Genomics, 2007 Mar. PMID 17207965, Free PMC Article
  5. A reference map of the human binary protein interactome. Luck K, et al. Nature, 2020 Apr. PMID 32296183, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

Replication interactions

Interaction Pubs
Knockdown of chromosome 10 open reading frame 82 (C10orf82) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ40268, MGC33547

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
sperm-associated microtubule inner protein 5
Names
sperm associated microtubule inner protein 5
uncharacterized protein C10orf82

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001330142.3 → NP_001317071.1  sperm-associated microtubule inner protein 5 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC016825, BC021737, BX117017, BX537582, HY204705
    Consensus CDS
    CCDS81510.1
    UniProtKB/Swiss-Prot
    B3KUM9, D3DRC3, K7EKP3, Q8WW14
    Related
    ENSP00000535289.1, ENST00000865230.1

  2. NM_001350930.2 → NP_001337859.1  sperm-associated microtubule inner protein 5 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC016825, AI218030, AI797771, BX106852, BX117017, BX537582, HY204705
    Consensus CDS
    CCDS81510.1
    UniProtKB/Swiss-Prot
    B3KUM9, D3DRC3, K7EKP3, Q8WW14
    Related
    ENSP00000535290.1, ENST00000865231.1

  3. NM_001350931.2 → NP_001337860.1  sperm-associated microtubule inner protein 5 isoform 2

    Status: VALIDATED

    Source sequence(s)
    BC021737, BX117017, BX537582, DB451139, HY204705
    Consensus CDS
    CCDS81510.1
    UniProtKB/Swiss-Prot
    B3KUM9, D3DRC3, K7EKP3, Q8WW14
    Related
    ENSP00000465712.1, ENST00000588184.2

  4. NM_144661.4 → NP_653262.1  sperm-associated microtubule inner protein 5 isoform 1

    See identical proteins and their annotated locations for NP_653262.1

    Status: VALIDATED

    Source sequence(s)
    BC021737
    Consensus CDS
    CCDS7596.1
    UniProtKB/Swiss-Prot
    Q8WW14
    Related
    ENSP00000358212.3, ENST00000369210.7

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    116662211..116670282 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047424663.1 → XP_047280619.1  sperm-associated microtubule inner protein 5 isoform X4

  2. XM_011539342.3 → XP_011537644.1  sperm-associated microtubule inner protein 5 isoform X2

    See identical proteins and their annotated locations for XP_011537644.1

  3. XM_011539341.2 → XP_011537643.1  sperm-associated microtubule inner protein 5 isoform X2

    See identical proteins and their annotated locations for XP_011537643.1

  4. XM_011539343.4 → XP_011537645.1  sperm-associated microtubule inner protein 5 isoform X3

  5. XM_011539340.4 → XP_011537642.1  sperm-associated microtubule inner protein 5 isoform X1

  6. XM_011539346.4 → XP_011537648.1  sperm-associated microtubule inner protein 5 isoform X5

    See identical proteins and their annotated locations for XP_011537648.1

  7. XM_011539347.4 → XP_011537649.1  sperm-associated microtubule inner protein 5 isoform X6

  8. XM_011539344.4 → XP_011537646.1  sperm-associated microtubule inner protein 5 isoform X5

    See identical proteins and their annotated locations for XP_011537646.1

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_025791790.1 Reference GRCh38.p14 PATCHES

    Range
    73207..81278 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054333106.1 → XP_054189081.1  sperm-associated microtubule inner protein 5 isoform X4

  2. XM_054333104.1 → XP_054189079.1  sperm-associated microtubule inner protein 5 isoform X2

  3. XM_054333103.1 → XP_054189078.1  sperm-associated microtubule inner protein 5 isoform X2

  4. XM_054333102.1 → XP_054189077.1  sperm-associated microtubule inner protein 5 isoform X1

  5. XM_054333105.1 → XP_054189080.1  sperm-associated microtubule inner protein 5 isoform X3

  6. XM_054333107.1 → XP_054189082.1  sperm-associated microtubule inner protein 5 isoform X5

  7. XM_054333108.1 → XP_054189083.1  sperm-associated microtubule inner protein 5 isoform X6

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    117556531..117564614 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054364919.1 → XP_054220894.1  sperm-associated microtubule inner protein 5 isoform X4

  2. XM_054364917.1 → XP_054220892.1  sperm-associated microtubule inner protein 5 isoform X2

  3. XM_054364916.1 → XP_054220891.1  sperm-associated microtubule inner protein 5 isoform X2

  4. XM_054364915.1 → XP_054220890.1  sperm-associated microtubule inner protein 5 isoform X1

  5. XM_054364918.1 → XP_054220893.1  sperm-associated microtubule inner protein 5 isoform X3

  6. XM_054364921.1 → XP_054220896.1  sperm-associated microtubule inner protein 5 isoform X5

  7. XM_054364920.1 → XP_054220895.1  sperm-associated microtubule inner protein 5 isoform X5

  8. XM_054364922.1 → XP_054220897.1  sperm-associated microtubule inner protein 5 isoform X6

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8WW14.3 GenPept UniProtKB/Swiss-Prot:Q8WW14

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