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FGFBP3 fibroblast growth factor binding protein 3 [ Homo sapiens (human) ]

Gene ID: 143282, updated on 5-Jul-2025
Official Symbol
FGFBP3provided by HGNC
Official Full Name
fibroblast growth factor binding protein 3provided by HGNC
Primary source
HGNC:HGNC:23428
See related
Ensembl:ENSG00000174721 MIM:620879; AllianceGenome:HGNC:23428
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FGF-BP3; C10orf13
Summary
Enables fibroblast growth factor binding activity and heparin binding activity. Acts upstream of or within positive regulation of fibroblast growth factor receptor signaling pathway and positive regulation of vascular permeability. Located in extracellular region. [provided by Alliance of Genome Resources, Jul 2025]
Expression
Biased expression in brain (RPKM 6.6), prostate (RPKM 0.9) and 13 other tissues See more
Orthologs
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See FGFBP3 in Genome Data Viewer
Location:
10q23.32
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (91906584..91909486, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (92788686..92791588, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (93666341..93669243, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3764 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2609 Neighboring gene TNKS2 divergent transcript Neighboring gene NANOG hESC enhancer GRCh37_chr10:93580083-93580584 Neighboring gene tankyrase 2 Neighboring gene signal recognition particle 9 pseudogene 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:93640869-93641370 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:93641371-93641870 Neighboring gene Sharpr-MPRA regulatory region 9903 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:93682269-93682802 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3765 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2611 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3766 Neighboring gene B-TFIID TATA-box binding protein associated factor 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:93805711-93806387 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr10:93816841-93817342 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr10:93835428-93836089 Neighboring gene cytoplasmic polyadenylation element binding protein 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3767 Neighboring gene uncharacterized LOC107984254

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Markers

Clone Names

  • MGC39320

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables fibroblast growth factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables growth factor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables growth factor binding IEA
Inferred from Electronic Annotation
more info
 
enables heparin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables heparin binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in extracellular matrix HDA PubMed 
located_in extracellular region IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
fibroblast growth factor-binding protein 3
Names
FGF-binding protein 3
FGFBP-3

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_152429.5NP_689642.3  fibroblast growth factor-binding protein 3 precursor

    See identical proteins and their annotated locations for NP_689642.3

    Status: VALIDATED

    Source sequence(s)
    AL359198, DR759872
    Consensus CDS
    CCDS7418.1
    UniProtKB/Swiss-Prot
    B2RD68, Q8NBN0, Q8TAT2
    Related
    ENSP00000339067.3, ENST00000311575.6
    Conserved Domains (1) summary
    pfam06473
    Location:27258
    FGF-BP1; FGF binding protein 1 (FGF-BP1)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    91906584..91909486 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    92788686..92791588 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)