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Ftl1 ferritin light polypeptide 1 [ Mus musculus (house mouse) ]

Gene ID: 14325, updated on 5-Mar-2024


Official Symbol
Ftl1provided by MGI
Official Full Name
ferritin light polypeptide 1provided by MGI
Primary source
See related
Ensembl:ENSMUSG00000050708 AllianceGenome:MGI:95589
Gene type
protein coding
RefSeq status
Mus musculus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ftl; Ftl-1; L-ferritin
Predicted to enable ferric iron binding activity; ferrous iron binding activity; and identical protein binding activity. Predicted to be involved in intracellular sequestering of iron ion. Predicted to be located in autolysosome. Predicted to be part of intracellular ferritin complex. Predicted to be active in cytoplasm. Is expressed in several structures, including central nervous system; ciliary body; liver; and retina nuclear layer. Human ortholog(s) of this gene implicated in basal ganglia disease; hyperferritinemia-cataract syndrome; neurodegeneration with brain iron accumulation 3; and neurodegenerative disease. Orthologous to human FTL (ferritin light chain). [provided by Alliance of Genome Resources, Apr 2022]
Ubiquitous expression in liver adult (RPKM 4436.7), adrenal adult (RPKM 2649.8) and 23 other tissues See more
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Genomic context

See Ftl1 in Genome Data Viewer
7 B3; 7 29.32 cM
Exon count:
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (45107368..45109310, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (45457944..45459886, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene RuvB-like AAA ATPase 2 Neighboring gene luteinizing hormone beta Neighboring gene STARR-positive B cell enhancer ABC_E349 Neighboring gene glycogen synthase 1, muscle Neighboring gene STARR-seq mESC enhancer starr_18840 Neighboring gene STARR-seq mESC enhancer starr_18841 Neighboring gene BCL2-associated X protein Neighboring gene dihydrodiol dehydrogenase Neighboring gene TUB like protein 2

Genomic regions, transcripts, and products


  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a


GeneRIFs: Gene References Into Functions

What's a GeneRIF?



Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem


Products Interactant Other Gene Complex Source Pubs Description

General gene information


Clone Names

  • MGC102130, MGC102131, MGC118079, MGC118080

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ferric iron binding IBA
Inferred from Biological aspect of Ancestor
more info
enables ferrous iron binding IBA
Inferred from Biological aspect of Ancestor
more info
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
enables iron ion binding ISO
Inferred from Sequence Orthology
more info
enables protein binding IPI
Inferred from Physical Interaction
more info
Process Evidence Code Pubs
involved_in intracellular sequestering of iron ion IBA
Inferred from Biological aspect of Ancestor
more info
Component Evidence Code Pubs
located_in autolysosome ISO
Inferred from Sequence Orthology
more info
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
located_in endocytic vesicle lumen TAS
Traceable Author Statement
more info
located_in extracellular region TAS
Traceable Author Statement
more info
part_of intracellular ferritin complex ISO
Inferred from Sequence Orthology
more info

General protein information

Preferred Names
ferritin light chain 1
ferritin L subunit 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010240.2NP_034370.2  ferritin light chain 1

    See identical proteins and their annotated locations for NP_034370.2

    Status: VALIDATED

    Source sequence(s)
    AK169159, BC081462, BY134899
    Consensus CDS
    P29391, Q8WUQ8
    Q3TJJ6, Q3UCL5, Q9CPX4
    ENSMUSP00000092002.5, ENSMUST00000094434.13
    Conserved Domains (1) summary
    Ferritin; Ferritin iron storage proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J


  1. NC_000073.7 Reference GRCm39 C57BL/6J

    45107368..45109310 complement
    GenBank, FASTA, Sequence Viewer (Graphics)