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Fth1 ferritin heavy polypeptide 1 [ Mus musculus (house mouse) ]

Gene ID: 14319, updated on 26-Feb-2024

Summary

Official Symbol
Fth1provided by MGI
Official Full Name
ferritin heavy polypeptide 1provided by MGI
Primary source
MGI:MGI:95588
See related
Ensembl:ENSMUSG00000024661 AllianceGenome:MGI:95588
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
FHC; Fth; HFt; MFH
Summary
Enables iron ion binding activity. Acts upstream of or within iron ion transport. Located in mitochondrion. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in hemochromatosis type 5. Orthologous to human FTH1 (ferritin heavy chain 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in duodenum adult (RPKM 10006.4), adrenal adult (RPKM 4705.3) and 14 other tissues See more
Orthologs
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Genomic context

See Fth1 in Genome Data Viewer
Location:
19 A; 19 6.23 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (9957964..9962475)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (9980600..9985111)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1972 Neighboring gene STARR-seq mESC enhancer starr_45534 Neighboring gene predicted gene, 50340 Neighboring gene predicted gene, 36913 Neighboring gene STARR-positive B cell enhancer ABC_E5686 Neighboring gene STARR-seq mESC enhancer starr_45537 Neighboring gene predicted gene, 41806 Neighboring gene bestrophin 1 Neighboring gene STARR-positive B cell enhancer mm9_chr19:10074872-10075172 Neighboring gene RAB3A interacting protein (rabin3)-like 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ferric iron binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ferric iron binding IEA
Inferred from Electronic Annotation
more info
 
enables ferrous iron binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ferrous iron binding ISO
Inferred from Sequence Orthology
more info
 
enables ferroxidase activity ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables iron ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables iron ion sequestering activity ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within intracellular iron ion homeostasis IEA
Inferred from Electronic Annotation
more info
 
involved_in intracellular iron ion homeostasis IEA
Inferred from Electronic Annotation
more info
 
involved_in intracellular sequestering of iron ion IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in iron ion transport IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within iron ion transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of fibroblast proliferation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in autolysosome ISO
Inferred from Sequence Orthology
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in endocytic vesicle lumen TAS
Traceable Author Statement
more info
 
located_in extracellular region TAS
Traceable Author Statement
more info
 
is_active_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion HDA PubMed 

General protein information

Preferred Names
ferritin heavy chain
Names
H-ferritin
ferritin H subunit
ferritin heavy chain 1
NP_034369.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010239.2NP_034369.1  ferritin heavy chain

    See identical proteins and their annotated locations for NP_034369.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the protein.
    Source sequence(s)
    AC134437, AK147082
    Consensus CDS
    CCDS29567.1
    UniProtKB/Swiss-Prot
    P09528, Q3UI44
    Related
    ENSMUSP00000025563.7, ENSMUST00000025563.8
    Conserved Domains (1) summary
    cd01056
    Location:14174
    Euk_Ferritin; eukaryotic ferritins

RNA

  1. NR_073181.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an extended 5' splice structure, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC134437, AK152702

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    9957964..9962475
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)