Tlr3 toll-like receptor 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tlr3provided by MGI
Official Full Name: toll-like receptor 3provided by MGI
Primary source: MGI:MGI:2156367
See related: Ensembl:ENSMUSG00000031639 AllianceGenome:MGI:2156367
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable double-stranded RNA binding activity; identical protein binding activity; and signaling receptor activity. Involved in several processes, including JNK cascade; positive regulation of angiogenesis; and positive regulation of cytokine production. Acts upstream of or within several processes, including positive regulation of NF-kappaB transcription factor activity; positive regulation of intracellular signal transduction; and regulation of cytokine production. Predicted to be located in cell surface and cytoplasm. Predicted to be integral component of plasma membrane. Is expressed in brain; cerebral cortex; cerebral cortex ventricular layer; forebrain; and submandibular gland primordium. Human ortholog(s) of this gene implicated in several diseases, including hepatitis B; hepatitis C; human immunodeficiency virus infectious disease; liver cirrhosis; and type 1 diabetes mellitus. Orthologous to human TLR3 (toll like receptor 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in bladder adult (RPKM 3.5), large intestine adult (RPKM 1.7) and 25 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8; 8 B1.1

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (45848702..45864112, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (45395665..45411075, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TLR3 stimulation improves the migratory potency of adipose-derived mesenchymal stem cells through the stress response pathway in the melanoma mouse model.
Title: TLR3 stimulation improves the migratory potency of adipose-derived mesenchymal stem cells through the stress response pathway in the melanoma mouse model.
Early activation of Toll-like receptor-3 reduces the pathological progression of Alzheimer's disease in APP/PS1 mouse.
Title: Early activation of Toll-like receptor-3 reduces the pathological progression of Alzheimer's disease in APP/PS1 mouse.
Photobiomodulation promotes spinal cord injury repair by inhibiting macrophage polarization through lncRNA TUG1-miR-1192/TLR3 axis.
Title: Photobiomodulation promotes spinal cord injury repair by inhibiting macrophage polarization through lncRNA TUG1-miR-1192/TLR3 axis.
LIGHT Amplification by NF-kappaB Contributes to TLR3 Signaling Pathway-Induced Acute Hepatitis.
Title: LIGHT Amplification by NF-κB Contributes to TLR3 Signaling Pathway-Induced Acute Hepatitis.
Intratracheal instillation of graphene oxide decreases anti-virus responses and lipid contents via suppressing Toll-like receptor 3 in mouse livers.
Title: Intratracheal instillation of graphene oxide decreases anti-virus responses and lipid contents via suppressing Toll-like receptor 3 in mouse livers.
Graphene oxide links alterations of anti-viral signaling pathways with lipid metabolism via suppressing TLR3 in vascular smooth muscle cells.
Title: Graphene oxide links alterations of anti-viral signaling pathways with lipid metabolism via suppressing TLR3 in vascular smooth muscle cells.
Toll-Like Receptor 3 (TLR3) Is Engaged in the Intracellular Survival of the Protozoan Parasite Leishmania (Leishmania) amazonensis.
Title: Toll-Like Receptor 3 (TLR3) Is Engaged in the Intracellular Survival of the Protozoan Parasite Leishmania (Leishmania) amazonensis.
Effect of inhibition of Toll-like receptor 3 signaling on pathogenesis of rabies virus in mouse model.
Title: Effect of inhibition of Toll-like receptor 3 signaling on pathogenesis of rabies virus in mouse model.
A genetic screen identifies a protective type III interferon response to Cryptosporidium that requires TLR3 dependent recognition.
Title: A genetic screen identifies a protective type III interferon response to Cryptosporidium that requires TLR3 dependent recognition.
TLR3-driven IFN-beta antagonizes STAT5-activating cytokines and suppresses innate type 2 response in the lung.
Title: TLR3-driven IFN-β antagonizes STAT5-activating cytokines and suppresses innate type 2 response in the lung.

Submit: New GeneRIF Correction See all GeneRIFs (300)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Chemically induced (ENU) (2)
Endonuclease-mediated (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Homologs of the Tlr3 gene: The Tlr3 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, fruit fly, mosquito, and frog.
Orthologs from Annotation Pipeline: 505 organisms have orthologs with human gene Tlr3
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables double-stranded RNA binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables pattern recognition receptor activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables transmembrane signaling receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables transmembrane signaling receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of I-kappaB kinase/NF-kappaB signaling	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of I-kappaB kinase/NF-kappaB signaling	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of I-kappaB kinase/NF-kappaB signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in I-kappaB phosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of JNK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in JNK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in MAPK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in MyD88-independent toll-like receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cellular response to exogenous dsRNA	ISO Inferred from Sequence Orthology more info
involved_in cellular response to virus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of chemokine production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within defense response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within defense response to virus	IGI Inferred from Genetic Interaction more info	PubMed
involved_in defense response to virus	TAS Traceable Author Statement more info	PubMed
involved_in extrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
involved_in inflammatory response	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in inflammatory response to wounding	IDA Inferred from Direct Assay more info	PubMed
involved_in innate immune response	TAS Traceable Author Statement more info	PubMed
acts_upstream_of interleukin-6 production	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of macrophage cytokine production	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of macrophage cytokine production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in microglial cell activation	ISO Inferred from Sequence Orthology more info
involved_in necroptotic signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of I-kappaB kinase/NF-kappaB signaling	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of I-kappaB kinase/NF-kappaB signaling	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of I-kappaB kinase/NF-kappaB signaling	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of JNK cascade	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of NF-kappaB transcription factor activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of NIK/NF-kappaB signaling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of angiogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of chemokine production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of chemokine production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytokine production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cytokine production involved in inflammatory response	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of interferon-alpha production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interferon-beta production	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of interferon-beta production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interferon-beta production	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of interleukin-12 production	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of interleukin-6 production	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of interleukin-6 production	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of interleukin-6 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of interleukin-6 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-8 production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of macrophage cytokine production	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of macrophage cytokine production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of toll-like receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of tumor necrosis factor production	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of tumor necrosis factor production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of type I interferon production	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of type II interferon production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of type III interferon production	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of dendritic cell cytokine production	IDA Inferred from Direct Assay more info	PubMed
involved_in response to dsRNA	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to exogenous dsRNA	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to exogenous dsRNA	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within response to virus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
involved_in toll-like receptor 3 signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in toll-like receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in toll-like receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of type I interferon production	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of type III interferon production	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in early endosome	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: toll-like receptor 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001357316.1 → NP_001344245.1 toll-like receptor 3 precursor

Status: VALIDATED

Source sequence(s)

AK083977, AK171438, BC099937

Consensus CDS

CCDS22278.1

UniProtKB/Swiss-Prot

Q91ZM4

Related

ENSMUSP00000147738.2, ENSMUST00000209772.2

Conserved Domains (7) summary

smart00082
Location:646 → 698

LRRCT; Leucine rich repeat C-terminal domain

smart00255
Location:756 → 901

TIR; Toll - interleukin 1 - resistance

PLN00113
Location:70 → 543

PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

sd00031
Location:589 → 610

LRR_1; leucine-rich repeat [structural motif]

sd00033
Location:277 → 300

LRR_RI; leucine-rich repeat [structural motif]

pfam17968
Location:699 → 731

Tlr3_TMD; Toll-like receptor 3 trans-membrane domain

cd21340
Location:503 → 649

PPP1R42; protein phosphatase 1 regulatory subunit 42
NM_001357317.1 → NP_001344246.1 toll-like receptor 3 precursor

Status: VALIDATED

Source sequence(s)

AC116861, AC120003

Consensus CDS

CCDS22278.1

UniProtKB/Swiss-Prot

Q91ZM4

Related

ENSMUSP00000126556.2, ENSMUST00000167106.3

Conserved Domains (7) summary

smart00082
Location:646 → 698

LRRCT; Leucine rich repeat C-terminal domain

smart00255
Location:756 → 901

TIR; Toll - interleukin 1 - resistance

PLN00113
Location:70 → 543

PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

sd00031
Location:589 → 610

LRR_1; leucine-rich repeat [structural motif]

sd00033
Location:277 → 300

LRR_RI; leucine-rich repeat [structural motif]

pfam17968
Location:699 → 731

Tlr3_TMD; Toll-like receptor 3 trans-membrane domain

cd21340
Location:503 → 649

PPP1R42; protein phosphatase 1 regulatory subunit 42
NM_126166.5 → NP_569054.2 toll-like receptor 3 precursor

See identical proteins and their annotated locations for NP_569054.2

Status: VALIDATED

Source sequence(s)

AK083977, BC099937, BY770706

Consensus CDS

CCDS22278.1

UniProtKB/Swiss-Prot

Q91ZM4, Q99MB1

Related

ENSMUSP00000034056.5, ENSMUST00000034056.12

Conserved Domains (7) summary

smart00082
Location:646 → 698

LRRCT; Leucine rich repeat C-terminal domain

smart00255
Location:756 → 901

TIR; Toll - interleukin 1 - resistance

PLN00113
Location:70 → 543

PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

sd00031
Location:589 → 610

LRR_1; leucine-rich repeat [structural motif]

sd00033
Location:277 → 300

LRR_RI; leucine-rich repeat [structural motif]

pfam17968
Location:699 → 731

Tlr3_TMD; Toll-like receptor 3 trans-membrane domain

cd21340
Location:503 → 649

PPP1R42; protein phosphatase 1 regulatory subunit 42

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

45848702..45864112 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006509279.3 → XP_006509342.1 toll-like receptor 3 isoform X1

See identical proteins and their annotated locations for XP_006509342.1

UniProtKB/Swiss-Prot

Q91ZM4, Q99MB1

Conserved Domains (7) summary

smart00082
Location:646 → 698

LRRCT; Leucine rich repeat C-terminal domain

smart00255
Location:756 → 901

TIR; Toll - interleukin 1 - resistance

PLN00113
Location:70 → 543

PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

sd00031
Location:589 → 610

LRR_1; leucine-rich repeat [structural motif]

sd00033
Location:277 → 300

LRR_RI; leucine-rich repeat [structural motif]

pfam17968
Location:699 → 731

Tlr3_TMD; Toll-like receptor 3 trans-membrane domain

cd21340
Location:503 → 649

PPP1R42; protein phosphatase 1 regulatory subunit 42
XM_006509280.4 → XP_006509343.1 toll-like receptor 3 isoform X1

See identical proteins and their annotated locations for XP_006509343.1

UniProtKB/Swiss-Prot

Q91ZM4, Q99MB1

Conserved Domains (7) summary

smart00082
Location:646 → 698

LRRCT; Leucine rich repeat C-terminal domain

smart00255
Location:756 → 901

TIR; Toll - interleukin 1 - resistance

PLN00113
Location:70 → 543

PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

sd00031
Location:589 → 610

LRR_1; leucine-rich repeat [structural motif]

sd00033
Location:277 → 300

LRR_RI; leucine-rich repeat [structural motif]

pfam17968
Location:699 → 731

Tlr3_TMD; Toll-like receptor 3 trans-membrane domain

cd21340
Location:503 → 649

PPP1R42; protein phosphatase 1 regulatory subunit 42
XM_006509281.4 → XP_006509344.1 toll-like receptor 3 isoform X1

See identical proteins and their annotated locations for XP_006509344.1

UniProtKB/Swiss-Prot

Q91ZM4, Q99MB1

Conserved Domains (7) summary

smart00082
Location:646 → 698

LRRCT; Leucine rich repeat C-terminal domain

smart00255
Location:756 → 901

TIR; Toll - interleukin 1 - resistance

PLN00113
Location:70 → 543

PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

sd00031
Location:589 → 610

LRR_1; leucine-rich repeat [structural motif]

sd00033
Location:277 → 300

LRR_RI; leucine-rich repeat [structural motif]

pfam17968
Location:699 → 731

Tlr3_TMD; Toll-like receptor 3 trans-membrane domain

cd21340
Location:503 → 649

PPP1R42; protein phosphatase 1 regulatory subunit 42
XM_006509283.4 → XP_006509346.1 toll-like receptor 3 isoform X1

See identical proteins and their annotated locations for XP_006509346.1

UniProtKB/Swiss-Prot

Q91ZM4, Q99MB1

Conserved Domains (7) summary

smart00082
Location:646 → 698

LRRCT; Leucine rich repeat C-terminal domain

smart00255
Location:756 → 901

TIR; Toll - interleukin 1 - resistance

PLN00113
Location:70 → 543

PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

sd00031
Location:589 → 610

LRR_1; leucine-rich repeat [structural motif]

sd00033
Location:277 → 300

LRR_RI; leucine-rich repeat [structural motif]

pfam17968
Location:699 → 731

Tlr3_TMD; Toll-like receptor 3 trans-membrane domain

cd21340
Location:503 → 649

PPP1R42; protein phosphatase 1 regulatory subunit 42
XM_006509278.4 → XP_006509341.1 toll-like receptor 3 isoform X1

See identical proteins and their annotated locations for XP_006509341.1

UniProtKB/Swiss-Prot

Q91ZM4, Q99MB1

Conserved Domains (7) summary

smart00082
Location:646 → 698

LRRCT; Leucine rich repeat C-terminal domain

smart00255
Location:756 → 901

TIR; Toll - interleukin 1 - resistance

PLN00113
Location:70 → 543

PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional

sd00031
Location:589 → 610

LRR_1; leucine-rich repeat [structural motif]

sd00033
Location:277 → 300

LRR_RI; leucine-rich repeat [structural motif]

pfam17968
Location:699 → 731

Tlr3_TMD; Toll-like receptor 3 trans-membrane domain

cd21340
Location:503 → 649

PPP1R42; protein phosphatase 1 regulatory subunit 42