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Tlr3 toll-like receptor 3 [ Mus musculus (house mouse) ]

Gene ID: 142980, updated on 27-Nov-2024

Summary

Official Symbol
Tlr3provided by MGI
Official Full Name
toll-like receptor 3provided by MGI
Primary source
MGI:MGI:2156367
See related
Ensembl:ENSMUSG00000031639 AllianceGenome:MGI:2156367
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables pattern recognition receptor activity; transmembrane signaling receptor activity; and ubiquitin-like protein ligase binding activity. Involved in several processes, including positive regulation of NF-kappaB transcription factor activity; positive regulation of angiogenesis; and positive regulation of macromolecule biosynthetic process. Acts upstream of or within several processes, including cellular response to exogenous dsRNA; positive regulation of intracellular signal transduction; and regulation of cytokine production. Is active in plasma membrane. Is expressed in blood; brain; and submandibular gland primordium. Human ortholog(s) of this gene implicated in several diseases, including hepatitis B; hepatitis C; human immunodeficiency virus infectious disease; liver cirrhosis; and primary immunodeficiency disease (multiple). Orthologous to human TLR3 (toll like receptor 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in bladder adult (RPKM 3.5), large intestine adult (RPKM 1.7) and 25 other tissues See more
Orthologs
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Genomic context

See Tlr3 in Genome Data Viewer
Location:
8 B1.1; 8 25.31 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (45848702..45864112, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (45395665..45411075, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30504 Neighboring gene cytochrome P450, family 4, subfamily v, polypeptide 3 Neighboring gene family with sequence similarity 149, member A Neighboring gene STARR-seq mESC enhancer starr_21371 Neighboring gene sorbin and SH3 domain containing 2 Neighboring gene predicted gene, 30759 Neighboring gene predicted gene 16351 Neighboring gene predicted gene, 23604

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables double-stranded RNA binding ISO
Inferred from Sequence Orthology
more info
 
enables double-stranded RNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables pattern recognition receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables pattern recognition receptor activity IGI
Inferred from Genetic Interaction
more info
PubMed 
enables pattern recognition receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables pattern recognition receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transmembrane signaling receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables ubiquitin-like protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in I-kappaB phosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of JNK cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in JNK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in MAPK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cellular response to exogenous dsRNA IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to exogenous dsRNA ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to interferon-beta IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to mechanical stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to type II interferon IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to virus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to xenobiotic stimulus IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of chemokine production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within defense response IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within defense response to virus IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in defense response to virus TAS
Traceable Author Statement
more info
PubMed 
involved_in extrinsic apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in extrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in inflammatory response to wounding IDA
Inferred from Direct Assay
more info
PubMed 
involved_in inflammatory response to wounding ISO
Inferred from Sequence Orthology
more info
 
involved_in innate immune response TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of interleukin-6 production IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of macrophage cytokine production IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of macrophage cytokine production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in male gonad development IEA
Inferred from Electronic Annotation
more info
 
involved_in microglial cell activation IEA
Inferred from Electronic Annotation
more info
 
involved_in microglial cell activation ISO
Inferred from Sequence Orthology
more info
 
involved_in necroptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in necroptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of JNK cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of JNK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of NF-kappaB transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of angiogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of canonical NF-kappaB signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of canonical NF-kappaB signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of canonical NF-kappaB signal transduction IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of canonical NF-kappaB signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of chemokine production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of chemokine production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cytokine production involved in inflammatory response IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interferon-alpha production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interferon-alpha production ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of interferon-beta production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of interferon-beta production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interferon-beta production ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in positive regulation of interleukin-12 production IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of interleukin-6 production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of interleukin-6 production IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of interleukin-6 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of interleukin-6 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-8 production IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of positive regulation of interleukin-8 production ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of macrophage cytokine production IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of macrophage cytokine production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of non-canonical NF-kappaB signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of non-canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of tumor necrosis factor production IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of tumor necrosis factor production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of type I interferon production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of type II interferon production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of type II interferon production ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within positive regulation of type III interferon production IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of dendritic cell cytokine production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to dsRNA ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to exogenous dsRNA IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to exogenous dsRNA ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within response to virus IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within toll-like receptor 3 signaling pathway ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in toll-like receptor 3 signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in toll-like receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in toll-like receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in toll-like receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of type I interferon production IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of type III interferon production IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in cell surface IEA
Inferred from Electronic Annotation
more info
 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in early endosome IEA
Inferred from Electronic Annotation
more info
 
is_active_in early endosome ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
located_in endosome membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357316.1 → NP_001344245.1  toll-like receptor 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AK083977, AK171438, BC099937
    Consensus CDS
    CCDS22278.1
    UniProtKB/Swiss-Prot
    Q91ZM4, Q99MB1
    UniProtKB/TrEMBL
    Q499F3
    Related
    ENSMUSP00000147738.2, ENSMUST00000209772.2
    Conserved Domains (7) summary
    smart00082
    Location:646 → 698
    LRRCT; Leucine rich repeat C-terminal domain
    smart00255
    Location:756 → 901
    TIR; Toll - interleukin 1 - resistance
    PLN00113
    Location:70 → 543
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    sd00031
    Location:589 → 610
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:277 → 300
    LRR_RI; leucine-rich repeat [structural motif]
    pfam17968
    Location:699 → 731
    Tlr3_TMD; Toll-like receptor 3 trans-membrane domain
    cd21340
    Location:503 → 649
    PPP1R42; protein phosphatase 1 regulatory subunit 42
  2. NM_001357317.1 → NP_001344246.1  toll-like receptor 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AC116861, AC120003
    Consensus CDS
    CCDS22278.1
    UniProtKB/Swiss-Prot
    Q91ZM4, Q99MB1
    UniProtKB/TrEMBL
    Q499F3
    Related
    ENSMUSP00000126556.2, ENSMUST00000167106.3
    Conserved Domains (7) summary
    smart00082
    Location:646 → 698
    LRRCT; Leucine rich repeat C-terminal domain
    smart00255
    Location:756 → 901
    TIR; Toll - interleukin 1 - resistance
    PLN00113
    Location:70 → 543
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    sd00031
    Location:589 → 610
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:277 → 300
    LRR_RI; leucine-rich repeat [structural motif]
    pfam17968
    Location:699 → 731
    Tlr3_TMD; Toll-like receptor 3 trans-membrane domain
    cd21340
    Location:503 → 649
    PPP1R42; protein phosphatase 1 regulatory subunit 42
  3. NM_126166.5 → NP_569054.2  toll-like receptor 3 precursor

    See identical proteins and their annotated locations for NP_569054.2

    Status: VALIDATED

    Source sequence(s)
    AK083977, BC099937, BY770706
    Consensus CDS
    CCDS22278.1
    UniProtKB/Swiss-Prot
    Q91ZM4, Q99MB1
    UniProtKB/TrEMBL
    Q499F3
    Related
    ENSMUSP00000034056.5, ENSMUST00000034056.12
    Conserved Domains (7) summary
    smart00082
    Location:646 → 698
    LRRCT; Leucine rich repeat C-terminal domain
    smart00255
    Location:756 → 901
    TIR; Toll - interleukin 1 - resistance
    PLN00113
    Location:70 → 543
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    sd00031
    Location:589 → 610
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:277 → 300
    LRR_RI; leucine-rich repeat [structural motif]
    pfam17968
    Location:699 → 731
    Tlr3_TMD; Toll-like receptor 3 trans-membrane domain
    cd21340
    Location:503 → 649
    PPP1R42; protein phosphatase 1 regulatory subunit 42

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    45848702..45864112 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006509279.3 → XP_006509342.1  toll-like receptor 3 isoform X1

    See identical proteins and their annotated locations for XP_006509342.1

    UniProtKB/Swiss-Prot
    Q91ZM4, Q99MB1
    UniProtKB/TrEMBL
    Q499F3
    Conserved Domains (7) summary
    smart00082
    Location:646 → 698
    LRRCT; Leucine rich repeat C-terminal domain
    smart00255
    Location:756 → 901
    TIR; Toll - interleukin 1 - resistance
    PLN00113
    Location:70 → 543
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    sd00031
    Location:589 → 610
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:277 → 300
    LRR_RI; leucine-rich repeat [structural motif]
    pfam17968
    Location:699 → 731
    Tlr3_TMD; Toll-like receptor 3 trans-membrane domain
    cd21340
    Location:503 → 649
    PPP1R42; protein phosphatase 1 regulatory subunit 42
  2. XM_006509280.4 → XP_006509343.1  toll-like receptor 3 isoform X1

    See identical proteins and their annotated locations for XP_006509343.1

    UniProtKB/Swiss-Prot
    Q91ZM4, Q99MB1
    UniProtKB/TrEMBL
    Q499F3
    Conserved Domains (7) summary
    smart00082
    Location:646 → 698
    LRRCT; Leucine rich repeat C-terminal domain
    smart00255
    Location:756 → 901
    TIR; Toll - interleukin 1 - resistance
    PLN00113
    Location:70 → 543
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    sd00031
    Location:589 → 610
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:277 → 300
    LRR_RI; leucine-rich repeat [structural motif]
    pfam17968
    Location:699 → 731
    Tlr3_TMD; Toll-like receptor 3 trans-membrane domain
    cd21340
    Location:503 → 649
    PPP1R42; protein phosphatase 1 regulatory subunit 42
  3. XM_006509281.4 → XP_006509344.1  toll-like receptor 3 isoform X1

    See identical proteins and their annotated locations for XP_006509344.1

    UniProtKB/Swiss-Prot
    Q91ZM4, Q99MB1
    UniProtKB/TrEMBL
    Q499F3
    Conserved Domains (7) summary
    smart00082
    Location:646 → 698
    LRRCT; Leucine rich repeat C-terminal domain
    smart00255
    Location:756 → 901
    TIR; Toll - interleukin 1 - resistance
    PLN00113
    Location:70 → 543
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    sd00031
    Location:589 → 610
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:277 → 300
    LRR_RI; leucine-rich repeat [structural motif]
    pfam17968
    Location:699 → 731
    Tlr3_TMD; Toll-like receptor 3 trans-membrane domain
    cd21340
    Location:503 → 649
    PPP1R42; protein phosphatase 1 regulatory subunit 42
  4. XM_006509283.4 → XP_006509346.1  toll-like receptor 3 isoform X1

    See identical proteins and their annotated locations for XP_006509346.1

    UniProtKB/Swiss-Prot
    Q91ZM4, Q99MB1
    UniProtKB/TrEMBL
    Q499F3
    Conserved Domains (7) summary
    smart00082
    Location:646 → 698
    LRRCT; Leucine rich repeat C-terminal domain
    smart00255
    Location:756 → 901
    TIR; Toll - interleukin 1 - resistance
    PLN00113
    Location:70 → 543
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    sd00031
    Location:589 → 610
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:277 → 300
    LRR_RI; leucine-rich repeat [structural motif]
    pfam17968
    Location:699 → 731
    Tlr3_TMD; Toll-like receptor 3 trans-membrane domain
    cd21340
    Location:503 → 649
    PPP1R42; protein phosphatase 1 regulatory subunit 42
  5. XM_006509278.4 → XP_006509341.1  toll-like receptor 3 isoform X1

    See identical proteins and their annotated locations for XP_006509341.1

    UniProtKB/Swiss-Prot
    Q91ZM4, Q99MB1
    UniProtKB/TrEMBL
    Q499F3
    Conserved Domains (7) summary
    smart00082
    Location:646 → 698
    LRRCT; Leucine rich repeat C-terminal domain
    smart00255
    Location:756 → 901
    TIR; Toll - interleukin 1 - resistance
    PLN00113
    Location:70 → 543
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    sd00031
    Location:589 → 610
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:277 → 300
    LRR_RI; leucine-rich repeat [structural motif]
    pfam17968
    Location:699 → 731
    Tlr3_TMD; Toll-like receptor 3 trans-membrane domain
    cd21340
    Location:503 → 649
    PPP1R42; protein phosphatase 1 regulatory subunit 42