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TRUB1 TruB pseudouridine synthase family member 1 [ Homo sapiens (human) ]

Gene ID: 142940, updated on 11-Jun-2021

Summary

Official Symbol
TRUB1provided by HGNC
Official Full Name
TruB pseudouridine synthase family member 1provided by HGNC
Primary source
HGNC:HGNC:16060
See related
Ensembl:ENSG00000165832 MIM:610726
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PUS4
Summary
Pseudouridine is an abundant component of rRNAs and tRNAs and is enzymatically generated by isomerization of uridine by pseudouridine synthase (Zucchini et al., 2003 [PubMed 12736709]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in adrenal (RPKM 19.3), testis (RPKM 13.5) and 24 other tissues See more
Orthologs
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Genomic context

See TRUB1 in Genome Data Viewer
Location:
10q25.3
Exon count:
8
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (114938195..114977676)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (116697954..116737435)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 3306 Neighboring gene ribosomal protein L15 pseudogene 13 Neighboring gene RNA, U6 small nuclear 1121, pseudogene Neighboring gene long intergenic non-protein coding RNA 2626 Neighboring gene uncharacterized LOC107984272

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables pseudouridine synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables pseudouridine synthase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in mRNA pseudouridine synthesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mRNA pseudouridine synthesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in tRNA modification IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
probable tRNA pseudouridine synthase 1
Names
TruB pseudouridine (psi) synthase family member 1
TruB pseudouridine (psi) synthase homolog 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_139169.5NP_631908.1  probable tRNA pseudouridine synthase 1

    See identical proteins and their annotated locations for NP_631908.1

    Status: VALIDATED

    Source sequence(s)
    AL355340, BC030601
    Consensus CDS
    CCDS7591.1
    UniProtKB/Swiss-Prot
    Q8WWH5
    Related
    ENSP00000298746.3, ENST00000298746.5
    Conserved Domains (1) summary
    cd02867
    Location:70348
    PseudoU_synth_TruB_4; Pseudouridine synthase homolog 4

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    114938195..114977676
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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