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ACSM6 acyl-CoA synthetase medium chain family member 6 [ Homo sapiens (human) ]

Gene ID: 142827, updated on 5-Jan-2022

Summary

Official Symbol
ACSM6provided by HGNC
Official Full Name
acyl-CoA synthetase medium chain family member 6provided by HGNC
Primary source
HGNC:HGNC:31665
See related
Ensembl:ENSG00000173124
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C10orf129; bA310E22.3
Summary
Predicted to enable fatty acid ligase activity and fatty-acyl-CoA synthase activity. Predicted to be involved in acyl-CoA metabolic process and fatty acid biosynthetic process. Predicted to be active in mitochondrial matrix. [provided by Alliance of Genome Resources, Nov 2021]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See ACSM6 in Genome Data Viewer
Location:
10q23.33
Exon count:
11
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (95194238..95228929)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (96953995..96988686)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984258 Neighboring gene uncharacterized LOC107984257 Neighboring gene pro-apoptotic WT1 regulator pseudogene 1 Neighboring gene Sharpr-MPRA regulatory region 568 Neighboring gene PDZ and LIM domain 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables GTP binding IEA
Inferred from Electronic Annotation
more info
 
enables butyrate-CoA ligase activity IEA
Inferred from Electronic Annotation
more info
 
enables fatty acid ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables fatty-acyl-CoA synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables medium-chain fatty acid-CoA ligase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in acyl-CoA metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in fatty acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
acyl-coenzyme A synthetase ACSM6, mitochondrial
Names
AMP-binding enzyme
NP_997204.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_207321.3NP_997204.2  acyl-coenzyme A synthetase ACSM6, mitochondrial precursor

    See identical proteins and their annotated locations for NP_997204.2

    Status: VALIDATED

    Source sequence(s)
    AK126134, BC063654, BC104211
    Consensus CDS
    CCDS7440.2
    UniProtKB/Swiss-Prot
    Q6P461
    Related
    ENSP00000340296.3, ENST00000341686.7
    Conserved Domains (2) summary
    pfam00501
    Location:76472
    AMP-binding; AMP-binding enzyme
    cl17068
    Location:45480
    AFD_class_I; Adenylate forming domain, Class I superfamily

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    95194238..95228929
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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