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Fosb FBJ osteosarcoma oncogene B [ Mus musculus (house mouse) ]

Gene ID: 14282, updated on 28-Dec-2019

Summary

Official Symbol
Fosbprovided by MGI
Official Full Name
FBJ osteosarcoma oncogene Bprovided by MGI
Primary source
MGI:MGI:95575
See related
Ensembl:ENSMUSG00000003545
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Expression
Broad expression in frontal lobe adult (RPKM 2.7), small intestine adult (RPKM 1.8) and 18 other tissues See more
Orthologs

Genomic context

See Fosb in Genome Data Viewer
Location:
7 A3; 7 9.56 cM
Exon count:
5
Annotation release Status Assembly Chr Location
108 current GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (19302696..19310118, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (19888045..19895394, complement)

Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene reticulon 2 (Z-band associated protein) Neighboring gene predicted gene, 51441 Neighboring gene predicted gene, 26802 Neighboring gene VISTA enhancer mm567 Neighboring gene excision repair cross-complementing rodent repair deficiency, complementation group 1 Neighboring gene CD3E antigen, epsilon polypeptide associated protein

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
cellular response to calcium ion IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
protein fosB
Names
osteosarcoma oncoprotein B FosB

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347586.1NP_001334515.1  protein fosB isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region which results in a frameshift, compared to variant 1. This difference results in a protein (isoform 2) with a shorter and distinct C-terminus, compared to isoform 1
    Source sequence(s)
    AC148988, AI846927, BC145082
    Consensus CDS
    CCDS85225.1
    UniProtKB/TrEMBL
    A0A140LIE4
    Related
    ENSMUSP00000146789.1, ENSMUST00000208446.1
    Conserved Domains (1) summary
    cd14721
    Location:165218
    bZIP_Fos; Basic leucine zipper (bZIP) domain of the oncogene Fos (Fos): a DNA-binding and dimerization domain
  2. NM_008036.2NP_032062.1  protein fosB isoform 1

    See identical proteins and their annotated locations for NP_032062.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC148988, AI846927, BU698478, BY337108, BY547195, CF356426, CK795975
    Consensus CDS
    CCDS20897.1
    UniProtKB/Swiss-Prot
    P13346
    UniProtKB/TrEMBL
    A2RSD4
    Related
    ENSMUSP00000003640.2, ENSMUST00000003640.3
    Conserved Domains (1) summary
    cd14721
    Location:165218
    bZIP_Fos; Basic leucine zipper (bZIP) domain of the oncogene Fos (Fos): a DNA-binding and dimerization domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p6 C57BL/6J

Genomic

  1. NC_000073.6 Reference GRCm38.p6 C57BL/6J

    Range
    19302696..19310118 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006539543.3XP_006539606.1  protein fosB isoform X1

    See identical proteins and their annotated locations for XP_006539606.1

    UniProtKB/Swiss-Prot
    P13346
    UniProtKB/TrEMBL
    A2RSD4
    Conserved Domains (1) summary
    cd14721
    Location:165218
    bZIP_Fos; Basic leucine zipper (bZIP) domain of the oncogene Fos (Fos): a DNA-binding and dimerization domain
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