Format

Send to:

Choose Destination

Folr2 folate receptor 2 (fetal) [ Mus musculus (house mouse) ]

Gene ID: 14276, updated on 25-Nov-2021

Summary

Official Symbol
Folr2provided by MGI
Official Full Name
folate receptor 2 (fetal)provided by MGI
Primary source
MGI:MGI:95569
See related
Ensembl:ENSMUSG00000032725
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
FBP2; FR-P3; Folbp2; FR-beta; Folbp-2
Summary
This gene encodes a receptor protein located on the plasma membrane that mediates folate uptake by cells. Mice lacking the product of this gene show no defects in embryonic development and grow normally into fertile adults. However, such mice were found to be highly susceptible to the teratogenic effects of arsenic. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2014]
Expression
Biased expression in mammary gland adult (RPKM 34.0), subcutaneous fat pad adult (RPKM 24.0) and 13 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Folr2 in Genome Data Viewer
Location:
7; 7 E2
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (101489195..101506397, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (101839988..101857190, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (108988502..109005704, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene ClpB caseinolytic peptidase B Neighboring gene paired-like homeobox 2a Neighboring gene inositol polyphosphate phosphatase-like 1 Neighboring gene predicted gene 10602 Neighboring gene folate receptor 1 (adult) Neighboring gene predicted gene, 35597

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables folic acid binding ISO
Inferred from Sequence Orthology
more info
 
enables folic acid binding TAS
Traceable Author Statement
more info
PubMed 
enables folic acid receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables folic acid receptor activity TAS
Traceable Author Statement
more info
PubMed 
enables signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in anchored component of external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in anchored component of external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in anchored component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
folate receptor beta
Names
folate binding protein 2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001303231.1NP_001290160.1  folate receptor beta precursor

    See identical proteins and their annotated locations for NP_001290160.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All variants (1-3) encode the same protein.
    Source sequence(s)
    AC159005
    Consensus CDS
    CCDS21516.1
    UniProtKB/Swiss-Prot
    Q05685
    Conserved Domains (1) summary
    pfam03024
    Location:29203
    Folate_rec; Folate receptor family
  2. NM_001303239.1NP_001290168.1  folate receptor beta precursor

    See identical proteins and their annotated locations for NP_001290168.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All variants (1-3) encode the same protein.
    Source sequence(s)
    AC159005, AC167240, BQ176722
    Consensus CDS
    CCDS21516.1
    UniProtKB/Swiss-Prot
    Q05685
    Related
    ENSMUSP00000147920.2, ENSMUST00000210598.2
    Conserved Domains (1) summary
    pfam03024
    Location:29203
    Folate_rec; Folate receptor family
  3. NM_008035.2NP_032061.1  folate receptor beta precursor

    See identical proteins and their annotated locations for NP_032061.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All variants (1-3) encode the same protein.
    Source sequence(s)
    AC159005, BQ176722, CJ049116
    Consensus CDS
    CCDS21516.1
    UniProtKB/Swiss-Prot
    Q05685
    Related
    ENSMUSP00000091692.6, ENSMUST00000094141.7
    Conserved Domains (1) summary
    pfam03024
    Location:29203
    Folate_rec; Folate receptor family

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    101489195..101506397 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center