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Folr1 folate receptor alpha [ Mus musculus (house mouse) ]

Gene ID: 14275, updated on 21-Apr-2024

Summary

Official Symbol
Folr1provided by MGI
Official Full Name
folate receptor alphaprovided by MGI
Primary source
MGI:MGI:95568
See related
Ensembl:ENSMUSG00000001827 AllianceGenome:MGI:95568
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
FBP1; Folbp1; Folbp-1
Summary
Predicted to enable carboxylic acid binding activity; folic acid receptor activity; and signaling receptor activity. Involved in circulatory system development; nervous system development; and regulation of signal transduction. Acts upstream of or within folic acid metabolic process. Predicted to be located in several cellular components, including apical plasma membrane; basolateral plasma membrane; and brush border membrane. Predicted to be anchored component of plasma membrane. Predicted to be anchored component of external side of plasma membrane. Is expressed in several structures, including brain; early conceptus; genitourinary system; gut; and retina. Human ortholog(s) of this gene implicated in cerebral folate receptor alpha deficiency. Orthologous to human FOLR1 (folate receptor alpha). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in kidney adult (RPKM 188.9), placenta adult (RPKM 82.7) and 1 other tissue See more
Orthologs
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Genomic context

Location:
7 E2; 7 54.67 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (101507551..101519974, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (101858331..101870788, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene inositol polyphosphate phosphatase-like 1 Neighboring gene predicted gene 10602 Neighboring gene folate receptor beta Neighboring gene STARR-seq mESC enhancer starr_19700 Neighboring gene predicted gene, 35597 Neighboring gene anaphase promoting complex C subunit 15 Neighboring gene STARR-positive B cell enhancer ABC_E2837 Neighboring gene STARR-positive B cell enhancer ABC_E1350 Neighboring gene transmembrane O-methyltransferase

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (2) 

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables folic acid binding ISO
Inferred from Sequence Orthology
more info
 
enables folic acid binding TAS
Traceable Author Statement
more info
PubMed 
enables folic acid receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables folic acid receptor activity TAS
Traceable Author Statement
more info
PubMed 
enables signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables signaling receptor activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in anterior neural tube closure IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in axon regeneration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cardiac neural crest cell migration involved in outflow tract morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cellular response to folic acid ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to folic acid TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within folic acid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in folic acid transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within folic acid transport TAS
Traceable Author Statement
more info
PubMed 
involved_in fusion of sperm to egg plasma membrane involved in single fertilization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in heart looping IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neural crest cell migration involved in heart formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in pharyngeal arch artery morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within post-translational protein targeting to endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of transforming growth factor beta receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to axon injury IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in sperm-egg recognition IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within vesicle-mediated transport TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in brush border membrane ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in membrane TAS
Traceable Author Statement
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in side of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
folate receptor alpha
Names
FR-alpha
folate receptor 1 (adult)
folate-binding protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252552.2NP_001239481.1  folate receptor alpha precursor

    See identical proteins and their annotated locations for NP_001239481.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. All 16 variants encode the same protein.
    Source sequence(s)
    AC167240
    Consensus CDS
    CCDS21517.1
    UniProtKB/Swiss-Prot
    P35846, Q9R222
    UniProtKB/TrEMBL
    A1A4B2
    Related
    ENSMUSP00000102598.2, ENSMUST00000106985.8
    Conserved Domains (1) summary
    pfam03024
    Location:34209
    Folate_rec; Folate receptor family
  2. NM_001252553.2NP_001239482.1  folate receptor alpha precursor

    See identical proteins and their annotated locations for NP_001239482.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses two different splice sites in the 5' UTR, compared to variant 1. All 16 variants encode the same protein.
    Source sequence(s)
    AC167240
    Consensus CDS
    CCDS21517.1
    UniProtKB/Swiss-Prot
    P35846, Q9R222
    UniProtKB/TrEMBL
    A1A4B2
    Conserved Domains (1) summary
    pfam03024
    Location:34209
    Folate_rec; Folate receptor family
  3. NM_001252554.2NP_001239483.1  folate receptor alpha precursor

    See identical proteins and their annotated locations for NP_001239483.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses a different splice site in the 5' UTR, compared to variant 1. All 16 variants encode the same protein.
    Source sequence(s)
    AC167240
    Consensus CDS
    CCDS21517.1
    UniProtKB/Swiss-Prot
    P35846, Q9R222
    UniProtKB/TrEMBL
    A1A4B2
    Related
    ENSMUSP00000102596.2, ENSMUST00000106983.8
    Conserved Domains (1) summary
    pfam03024
    Location:34209
    Folate_rec; Folate receptor family
  4. NM_001412428.1NP_001399357.1  folate receptor alpha precursor

    Status: VALIDATED

    Source sequence(s)
    AC167240
    UniProtKB/Swiss-Prot
    P35846, Q9R222
  5. NM_001412429.1NP_001399358.1  folate receptor alpha precursor

    Status: VALIDATED

    Source sequence(s)
    AC167240
    UniProtKB/Swiss-Prot
    P35846, Q9R222
  6. NM_001412430.1NP_001399359.1  folate receptor alpha precursor

    Status: VALIDATED

    Source sequence(s)
    AC167240
    UniProtKB/Swiss-Prot
    P35846, Q9R222
  7. NM_001412431.1NP_001399360.1  folate receptor alpha precursor

    Status: VALIDATED

    Source sequence(s)
    AC167240
    UniProtKB/Swiss-Prot
    P35846, Q9R222
  8. NM_001412432.1NP_001399361.1  folate receptor alpha precursor

    Status: VALIDATED

    Source sequence(s)
    AC167240
    UniProtKB/Swiss-Prot
    P35846, Q9R222
  9. NM_001412433.1NP_001399362.1  folate receptor alpha precursor

    Status: VALIDATED

    Source sequence(s)
    AC167240
    UniProtKB/Swiss-Prot
    P35846, Q9R222
  10. NM_001412434.1NP_001399363.1  folate receptor alpha precursor

    Status: VALIDATED

    Source sequence(s)
    AC167240
    UniProtKB/Swiss-Prot
    P35846, Q9R222
  11. NM_001412435.1NP_001399364.1  folate receptor alpha precursor

    Status: VALIDATED

    Source sequence(s)
    AC167240
    UniProtKB/Swiss-Prot
    P35846, Q9R222
  12. NM_001412436.1NP_001399365.1  folate receptor alpha precursor

    Status: VALIDATED

    Source sequence(s)
    AC167240
    UniProtKB/Swiss-Prot
    P35846, Q9R222
    Related
    ENSMUSP00000102595.2, ENSMUST00000106982.8
  13. NM_001412437.1NP_001399366.1  folate receptor alpha precursor

    Status: VALIDATED

    Source sequence(s)
    AC167240
    UniProtKB/Swiss-Prot
    P35846, Q9R222
  14. NM_001412438.1NP_001399367.1  folate receptor alpha precursor

    Status: VALIDATED

    Source sequence(s)
    AC167240
    UniProtKB/Swiss-Prot
    P35846, Q9R222
  15. NM_001412439.1NP_001399368.1  folate receptor alpha precursor

    Status: VALIDATED

    Source sequence(s)
    AC167240
    UniProtKB/Swiss-Prot
    P35846, Q9R222
    Related
    ENSMUSP00000102594.2, ENSMUST00000106981.8
  16. NM_008034.4NP_032060.2  folate receptor alpha precursor

    See identical proteins and their annotated locations for NP_032060.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses a different splice site in the 5' UTR, compared to variant 1. All 16 variants encode the same protein.
    Source sequence(s)
    AC167240
    Consensus CDS
    CCDS21517.1
    UniProtKB/Swiss-Prot
    P35846, Q9R222
    UniProtKB/TrEMBL
    A1A4B2
    Related
    ENSMUSP00000102599.3, ENSMUST00000106986.9
    Conserved Domains (1) summary
    pfam03024
    Location:34209
    Folate_rec; Folate receptor family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    101507551..101519974 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006507369.3XP_006507432.1  folate receptor alpha isoform X1

    See identical proteins and their annotated locations for XP_006507432.1

    UniProtKB/Swiss-Prot
    P35846, Q9R222
    UniProtKB/TrEMBL
    A1A4B2
    Conserved Domains (1) summary
    pfam03024
    Location:34209
    Folate_rec; Folate receptor family
  2. XM_006507366.4XP_006507429.1  folate receptor alpha isoform X1

    See identical proteins and their annotated locations for XP_006507429.1

    UniProtKB/Swiss-Prot
    P35846, Q9R222
    UniProtKB/TrEMBL
    A1A4B2
    Conserved Domains (1) summary
    pfam03024
    Location:34209
    Folate_rec; Folate receptor family
  3. XM_006507364.4XP_006507427.1  folate receptor alpha isoform X1

    See identical proteins and their annotated locations for XP_006507427.1

    UniProtKB/Swiss-Prot
    P35846, Q9R222
    UniProtKB/TrEMBL
    A1A4B2
    Conserved Domains (1) summary
    pfam03024
    Location:34209
    Folate_rec; Folate receptor family
  4. XM_006507367.5XP_006507430.1  folate receptor alpha isoform X1

    See identical proteins and their annotated locations for XP_006507430.1

    UniProtKB/Swiss-Prot
    P35846, Q9R222
    UniProtKB/TrEMBL
    A1A4B2
    Conserved Domains (1) summary
    pfam03024
    Location:34209
    Folate_rec; Folate receptor family