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Folr1 folate receptor 1 (adult) [ Mus musculus (house mouse) ]

Gene ID: 14275, updated on 31-Jan-2019

Summary

Official Symbol
Folr1provided by MGI
Official Full Name
folate receptor 1 (adult)provided by MGI
Primary source
MGI:MGI:95568
See related
Ensembl:ENSMUSG00000001827
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
FBP1; Folbp1; Folbp-1
Expression
Biased expression in kidney adult (RPKM 188.9), placenta adult (RPKM 82.7) and 1 other tissue See more
Orthologs

Genomic context

See Folr1 in Genome Data Viewer
Location:
7; 7 E2
Exon count:
10
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 7 NC_000073.6 (101858331..101870788, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (109006845..109019197, complement)

Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene paired-like homeobox 2a Neighboring gene inositol polyphosphate phosphatase-like 1 Neighboring gene uncharacterized LOC102639173 Neighboring gene folate receptor 2 (fetal) Neighboring gene predicted gene, 35597 Neighboring gene anaphase prompoting complex C subunit 15 Neighboring gene transmembrane O-methyltransferase

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
drug binding ISO
Inferred from Sequence Orthology
more info
 
folic acid binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
folic acid binding ISO
Inferred from Sequence Orthology
more info
 
folic acid binding TAS
Traceable Author Statement
more info
PubMed 
folic acid receptor activity ISO
Inferred from Sequence Orthology
more info
 
folic acid receptor activity TAS
Traceable Author Statement
more info
PubMed 
methotrexate binding ISO
Inferred from Sequence Orthology
more info
 
signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
signaling receptor activity TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
anchored component of external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
anchored component of external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
anchored component of membrane IEA
Inferred from Electronic Annotation
more info
 
anchored component of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
brush border ISO
Inferred from Sequence Orthology
more info
 
brush border membrane ISO
Inferred from Sequence Orthology
more info
 
cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
endosome IEA
Inferred from Electronic Annotation
more info
 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
membrane TAS
Traceable Author Statement
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
folate receptor alpha
Names
FR-alpha
folate-binding protein 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252552.1NP_001239481.1  folate receptor alpha precursor

    See identical proteins and their annotated locations for NP_001239481.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, 3, and 4 all encode the same protein.
    Source sequence(s)
    AF096319, BC138795, CD241494, CJ079096
    Consensus CDS
    CCDS21517.1
    UniProtKB/Swiss-Prot
    P35846
    Related
    ENSMUSP00000102598.1, ENSMUST00000106985.7
    Conserved Domains (1) summary
    pfam03024
    Location:34209
    Folate_rec; Folate receptor family
  2. NM_001252553.1NP_001239482.1  folate receptor alpha precursor

    See identical proteins and their annotated locations for NP_001239482.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses two different splice sites in the 5' UTR, compared to variant 1. Variants 1, 2, 3, and 4 all encode the same protein.
    Source sequence(s)
    AF096319, BC138781, CD241494
    Consensus CDS
    CCDS21517.1
    UniProtKB/Swiss-Prot
    P35846
    Conserved Domains (1) summary
    pfam03024
    Location:34209
    Folate_rec; Folate receptor family
  3. NM_001252554.1NP_001239483.1  folate receptor alpha precursor

    See identical proteins and their annotated locations for NP_001239483.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses a different splice site in the 5' UTR, compared to variant 1. Variants 1, 2, 3, and 4 all encode the same protein.
    Source sequence(s)
    AF096319, BC138781, CD241494, CF617679
    Consensus CDS
    CCDS21517.1
    UniProtKB/Swiss-Prot
    P35846
    Related
    ENSMUSP00000102596.1, ENSMUST00000106983.7
    Conserved Domains (1) summary
    pfam03024
    Location:34209
    Folate_rec; Folate receptor family
  4. NM_008034.3NP_032060.2  folate receptor alpha precursor

    See identical proteins and their annotated locations for NP_032060.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses a different splice site in the 5' UTR, compared to variant 1. Variants 1, 2, 3, and 4 all encode the same protein.
    Source sequence(s)
    AF096319, CD241494
    Consensus CDS
    CCDS21517.1
    UniProtKB/Swiss-Prot
    P35846
    Related
    ENSMUSP00000102599.2, ENSMUST00000106986.8
    Conserved Domains (1) summary
    pfam03024
    Location:34209
    Folate_rec; Folate receptor family

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000073.6 Reference GRCm38.p4 C57BL/6J

    Range
    101858331..101870788 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006507360.3XP_006507423.1  folate receptor alpha isoform X1

    See identical proteins and their annotated locations for XP_006507423.1

    UniProtKB/Swiss-Prot
    P35846
    Conserved Domains (1) summary
    pfam03024
    Location:34209
    Folate_rec; Folate receptor family
  2. XM_006507363.3XP_006507426.1  folate receptor alpha isoform X1

    See identical proteins and their annotated locations for XP_006507426.1

    UniProtKB/Swiss-Prot
    P35846
    Conserved Domains (1) summary
    pfam03024
    Location:34209
    Folate_rec; Folate receptor family
  3. XM_006507369.3XP_006507432.1  folate receptor alpha isoform X1

    See identical proteins and their annotated locations for XP_006507432.1

    UniProtKB/Swiss-Prot
    P35846
    Conserved Domains (1) summary
    pfam03024
    Location:34209
    Folate_rec; Folate receptor family
  4. XM_006507368.3XP_006507431.1  folate receptor alpha isoform X1

    See identical proteins and their annotated locations for XP_006507431.1

    UniProtKB/Swiss-Prot
    P35846
    Related
    ENSMUSP00000102595.1, ENSMUST00000106982.7
    Conserved Domains (1) summary
    pfam03024
    Location:34209
    Folate_rec; Folate receptor family
  5. XM_006507370.3XP_006507433.1  folate receptor alpha isoform X1

    See identical proteins and their annotated locations for XP_006507433.1

    UniProtKB/Swiss-Prot
    P35846
    Related
    ENSMUSP00000102594.1, ENSMUST00000106981.7
    Conserved Domains (1) summary
    pfam03024
    Location:34209
    Folate_rec; Folate receptor family
  6. XM_006507365.3XP_006507428.1  folate receptor alpha isoform X1

    See identical proteins and their annotated locations for XP_006507428.1

    UniProtKB/Swiss-Prot
    P35846
    Conserved Domains (1) summary
    pfam03024
    Location:34209
    Folate_rec; Folate receptor family
  7. XM_006507366.2XP_006507429.1  folate receptor alpha isoform X1

    See identical proteins and their annotated locations for XP_006507429.1

    UniProtKB/Swiss-Prot
    P35846
    Conserved Domains (1) summary
    pfam03024
    Location:34209
    Folate_rec; Folate receptor family
  8. XM_006507364.2XP_006507427.1  folate receptor alpha isoform X1

    See identical proteins and their annotated locations for XP_006507427.1

    UniProtKB/Swiss-Prot
    P35846
    Conserved Domains (1) summary
    pfam03024
    Location:34209
    Folate_rec; Folate receptor family
  9. XM_006507361.2XP_006507424.1  folate receptor alpha isoform X1

    See identical proteins and their annotated locations for XP_006507424.1

    UniProtKB/Swiss-Prot
    P35846
    Conserved Domains (1) summary
    pfam03024
    Location:34209
    Folate_rec; Folate receptor family
  10. XM_006507367.3XP_006507430.1  folate receptor alpha isoform X1

    See identical proteins and their annotated locations for XP_006507430.1

    UniProtKB/Swiss-Prot
    P35846
    Conserved Domains (1) summary
    pfam03024
    Location:34209
    Folate_rec; Folate receptor family
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