U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Srgap2 SLIT-ROBO Rho GTPase activating protein 2 [ Mus musculus (house mouse) ]

Gene ID: 14270, updated on 12-May-2024

Summary

Official Symbol
Srgap2provided by MGI
Official Full Name
SLIT-ROBO Rho GTPase activating protein 2provided by MGI
Primary source
MGI:MGI:109605
See related
Ensembl:ENSMUSG00000026425 AllianceGenome:MGI:109605
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
FBP2; Fnbp2; srGAP3; 9930124L22Rik
Summary
Enables GTPase activator activity; protein homodimerization activity; and small GTPase binding activity. Involved in plasma membrane bounded cell projection organization and positive regulation of GTPase activity. Located in several cellular components, including phagocytic vesicle; postsynaptic density; and postsynaptic membrane. Is expressed in several structures, including brain; eye; future spinal cord; heart; and spinal cord. Orthologous to human SRGAP2 (SLIT-ROBO Rho GTPase activating protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cerebellum adult (RPKM 9.6), CNS E18 (RPKM 8.8) and 27 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Srgap2 in Genome Data Viewer
Location:
1 E4; 1 56.93 cM
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (131212989..131455269, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (131285251..131527531, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene Ras association (RalGDS/AF-6) domain family member 5 Neighboring gene bystin-like pseudogene Neighboring gene predicted gene 28913 Neighboring gene STARR-positive B cell enhancer ABC_E10034 Neighboring gene inhibitor of kappaB kinase epsilon Neighboring gene predicted gene, 51644 Neighboring gene STARR-positive B cell enhancer ABC_E5796 Neighboring gene STARR-positive B cell enhancer ABC_E5797 Neighboring gene predicted gene, 53252 Neighboring gene STARR-seq mESC enhancer starr_02218 Neighboring gene STARR-positive B cell enhancer ABC_E23 Neighboring gene STARR-positive B cell enhancer ABC_E8941 Neighboring gene STARR-positive B cell enhancer ABC_E5798 Neighboring gene STARR-seq mESC enhancer starr_02220 Neighboring gene family with sequence similarity 72, member A Neighboring gene STARR-positive B cell enhancer ABC_E11085 Neighboring gene arginine vasopressin receptor 1B Neighboring gene adaptor-related protein complex AP-1, sigma 3 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Gene trapped (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables GTPase activator activity ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables small GTPase binding IDA
Inferred from Direct Assay
more info
PubMed 
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in dendritic spine IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendritic spine head ISO
Inferred from Sequence Orthology
more info
 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in lamellipodium ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial inner membrane HDA PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in phagocytic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 
located_in postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 
located_in postsynaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
SLIT-ROBO Rho GTPase-activating protein 2
Names
FBP-27
formin binding protein 2
formin-binding protein 27

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081011.2NP_001074480.2  SLIT-ROBO Rho GTPase-activating protein 2

    See identical proteins and their annotated locations for NP_001074480.2

    Status: VALIDATED

    Source sequence(s)
    AC165436, AK084412, BC030457, BY779945, CF164437
    Consensus CDS
    CCDS48355.1
    UniProtKB/Swiss-Prot
    B2RY13, Q3V1V8, Q61054, Q91Z67
    UniProtKB/TrEMBL
    A0A2X0SZ45
    Related
    ENSMUSP00000095195.3, ENSMUST00000097588.9
    Conserved Domains (3) summary
    cd07682
    Location:26289
    F-BAR_srGAP2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Slit-Robo GTPase Activating Protein 2
    cd11955
    Location:732784
    SH3_srGAP1-3; Src homology 3 domain of Slit-Robo GTPase Activating Proteins 1, 2, and 3
    cd04383
    Location:487674
    RhoGAP_srGAP; RhoGAP_srGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in srGAPs. srGAPs are components of the intracellular part of Slit-Robo signalling pathway that is important for axon guidance and cell migration. srGAPs ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    131212989..131455269 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036160225.1XP_036016118.1  SLIT-ROBO Rho GTPase-activating protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A087WNM1
    Related
    ENSMUSP00000139405.2, ENSMUST00000186543.7
    Conserved Domains (3) summary
    cd11955
    Location:732784
    SH3_srGAP1-3; Src homology 3 domain of Slit-Robo GTPase Activating Proteins 1, 2, and 3
    cd04383
    Location:487674
    RhoGAP_srGAP; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in srGAPs. srGAPs are components of the intracellular part of Slit-Robo signalling pathway that is important for axon guidance and cell migration. srGAPs contain an ...
    cl12013
    Location:26289
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

RNA

  1. XR_001781100.2 RNA Sequence

  2. XR_004939453.1 RNA Sequence

  3. XR_001781103.2 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_019520.1: Suppressed sequence

    Description
    NM_019520.1: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.