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ASB12 ankyrin repeat and SOCS box containing 12 [ Homo sapiens (human) ]

Gene ID: 142689, updated on 7-Jun-2020

Summary

Official Symbol
ASB12provided by HGNC
Official Full Name
ankyrin repeat and SOCS box containing 12provided by HGNC
Primary source
HGNC:HGNC:19763
See related
Ensembl:ENSG00000198881 MIM:300891
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and a SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. [provided by RefSeq, Jan 2011]
Expression
Low expression observed in reference dataset See more
Orthologs

Genomic context

See ASB12 in Genome Data Viewer
Location:
Xq11.2
Exon count:
3
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (64224194..64230607, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (63444072..63450511, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene APC membrane recruitment protein 1 Neighboring gene RNA, 7SL, cytoplasmic 799, pseudogene Neighboring gene myotubularin related protein 8 Neighboring gene uncharacterized LOC112268307 Neighboring gene KPNA4 pseudogene 1 Neighboring gene SHC adaptor protein 1 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of ankyrin repeat and SOCS box containing 12 (ASB12) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: MTMR8

Homology

Clone Names

  • FLJ39577

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
contributes_to ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
post-translational protein modification TAS
Traceable Author Statement
more info
 
protein ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
ankyrin repeat and SOCS box protein 12
Names
ankyrin repeat domain-containing SOCS box protein Asb-12

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012823.2 RefSeqGene

    Range
    5025..11438
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_130388.4NP_569059.3  ankyrin repeat and SOCS box protein 12

    See identical proteins and their annotated locations for NP_569059.3

    Status: REVIEWED

    Source sequence(s)
    AA349954, AK096896, BC069555
    Consensus CDS
    CCDS14378.2
    UniProtKB/Swiss-Prot
    Q8WXK4
    Related
    ENSP00000355195.2, ENST00000362002.3
    Conserved Domains (4) summary
    cd00204
    Location:75201
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam07525
    Location:277315
    SOCS_box; SOCS box
    pfam12796
    Location:77168
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:75103
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    64224194..64230607 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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