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ASB14 ankyrin repeat and SOCS box containing 14 [ Homo sapiens (human) ]

Gene ID: 142686, updated on 1-Aug-2020

Summary

Official Symbol
ASB14provided by HGNC
Official Full Name
ankyrin repeat and SOCS box containing 14provided by HGNC
Primary source
HGNC:HGNC:19766
See related
Ensembl:ENSG00000239388
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and a SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Dec 2008]
Expression
Ubiquitous expression in heart (RPKM 1.8), bone marrow (RPKM 1.0) and 25 other tissues See more
Orthologs

Genomic context

See ASB14 in Genome Data Viewer
Location:
3p14.3
Exon count:
11
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (57268342..57293048, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (57302379..57326753, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene interleukin 17 receptor D Neighboring gene uncharacterized LOC105377101 Neighboring gene HESX homeobox 1 Neighboring gene uncharacterized LOC105377102 Neighboring gene adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 Neighboring gene dynein axonemal heavy chain 12 Neighboring gene RNA, U6 small nuclear 1181, pseudogene Neighboring gene ring finger protein 7 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp313L0121

Gene Ontology Provided by GOA

Process Evidence Code Pubs
intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
post-translational protein modification TAS
Traceable Author Statement
more info
 
protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
ankyrin repeat and SOCS box protein 14
Names
ankyrin repeat domain-containing SOCS box protein Asb-14

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001142733.3NP_001136205.2  ankyrin repeat and SOCS box protein 14 isoform 1

    See identical proteins and their annotated locations for NP_001136205.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC093928, AL832472
    Consensus CDS
    CCDS46856.2
    UniProtKB/Swiss-Prot
    A6NK59
    Related
    ENSP00000419199.1, ENST00000487349.6
    Conserved Domains (4) summary
    cd00204
    Location:116236
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd03730
    Location:529585
    SOCS_ASB14; SOCS (suppressors of cytokine signaling) box of ASB14-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. ...
    sd00045
    Location:182213
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:57147
    Ank_2; Ankyrin repeats (3 copies)
  2. NM_130387.5NP_569058.1  ankyrin repeat and SOCS box protein 14 isoform 2 precursor

    See identical proteins and their annotated locations for NP_569058.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region, compared to variant 1. The encoded isoform (2) has a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AF403032, AL832472, BE004392
    UniProtKB/Swiss-Prot
    A6NK59
    Conserved Domains (4) summary
    cd00204
    Location:29156
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd03730
    Location:244300
    SOCS_ASB14; SOCS (suppressors of cytokine signaling) box of ASB14-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. ...
    pfam12796
    Location:34129
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:3168
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    57268342..57293048 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017005737.2XP_016861226.1  ankyrin repeat and SOCS box protein 14 isoform X1

    UniProtKB/Swiss-Prot
    A6NK59
    Conserved Domains (4) summary
    cd00204
    Location:116236
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd03730
    Location:529585
    SOCS_ASB14; SOCS (suppressors of cytokine signaling) box of ASB14-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. ...
    sd00045
    Location:182213
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:57147
    Ank_2; Ankyrin repeats (3 copies)
  2. XM_024453355.1XP_024309123.1  ankyrin repeat and SOCS box protein 14 isoform X1

    Conserved Domains (4) summary
    cd00204
    Location:116236
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd03730
    Location:529585
    SOCS_ASB14; SOCS (suppressors of cytokine signaling) box of ASB14-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. ...
    sd00045
    Location:182213
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:57147
    Ank_2; Ankyrin repeats (3 copies)
  3. XM_017005736.2XP_016861225.1  ankyrin repeat and SOCS box protein 14 isoform X1

    UniProtKB/Swiss-Prot
    A6NK59
    Conserved Domains (4) summary
    cd00204
    Location:116236
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd03730
    Location:529585
    SOCS_ASB14; SOCS (suppressors of cytokine signaling) box of ASB14-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. ...
    sd00045
    Location:182213
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:57147
    Ank_2; Ankyrin repeats (3 copies)
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