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ASB15 ankyrin repeat and SOCS box containing 15 [ Homo sapiens (human) ]

Gene ID: 142685, updated on 7-Jun-2020

Summary

Official Symbol
ASB15provided by HGNC
Official Full Name
ankyrin repeat and SOCS box containing 15provided by HGNC
Primary source
HGNC:HGNC:19767
See related
Ensembl:ENSG00000146809
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a member of the suppressor of cytokine signaling box superfamily. The proteins in this superfamily participate in the ubiquitin-proteasome system for the degradation of proteins in the cell cycle and signal transduction pathways. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
Expression
Biased expression in heart (RPKM 6.0), kidney (RPKM 2.1) and 2 other tissues See more
Orthologs

Genomic context

See ASB15 in Genome Data Viewer
Location:
7q31.32
Exon count:
17
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (123567003..123639481)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (123241882..123277951)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene LYPLA1 pseudogene 1 Neighboring gene RNA, U6 small nuclear 296, pseudogene Neighboring gene IQ motif and ubiquitin domain containing Neighboring gene NADH:ubiquinone oxidoreductase subunit A5 Neighboring gene ASB15 antisense RNA 1 Neighboring gene leiomodin 2 Neighboring gene WASP like actin nucleation promoting factor

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ43370, DKFZp779M1258

Gene Ontology Provided by GOA

Process Evidence Code Pubs
intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
 
post-translational protein modification TAS
Traceable Author Statement
more info
 
protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
ankyrin repeat and SOCS box protein 15
Names
epididymis secretory sperm binding protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_034019.1 RefSeqGene

    Range
    4955..42615
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001290258.2NP_001277187.1  ankyrin repeat and SOCS box protein 15

    See identical proteins and their annotated locations for NP_001277187.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC006333, AF403033, AK125360, BC100874, CR749595
    Consensus CDS
    CCDS34742.1
    UniProtKB/Swiss-Prot
    Q8WXK1
    Related
    ENSP00000416433.1, ENST00000451215.6
    Conserved Domains (4) summary
    COG0666
    Location:25205
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd00204
    Location:138263
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:178207
    ANK; ANK repeat [structural motif]
    cl02533
    Location:532587
    SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
  2. NM_080928.4NP_563616.3  ankyrin repeat and SOCS box protein 15

    See identical proteins and their annotated locations for NP_563616.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC006333, AF403033, AK125360, BC100874, CR749595
    Consensus CDS
    CCDS34742.1
    UniProtKB/Swiss-Prot
    Q8WXK1
    Related
    ENSP00000275699.3, ENST00000275699.4
    Conserved Domains (4) summary
    COG0666
    Location:25205
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd00204
    Location:138263
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:178207
    ANK; ANK repeat [structural motif]
    cl02533
    Location:532587
    SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    123567003..123639481
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011515819.2XP_011514121.1  ankyrin repeat and SOCS box protein 15 isoform X2

    See identical proteins and their annotated locations for XP_011514121.1

    UniProtKB/Swiss-Prot
    Q8WXK1
    Conserved Domains (4) summary
    COG0666
    Location:25205
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd00204
    Location:138263
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:178207
    ANK; ANK repeat [structural motif]
    cl02533
    Location:532587
    SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
  2. XM_017011757.1XP_016867246.1  ankyrin repeat and SOCS box protein 15 isoform X2

    UniProtKB/Swiss-Prot
    Q8WXK1
    Conserved Domains (4) summary
    COG0666
    Location:25205
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd00204
    Location:138263
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:178207
    ANK; ANK repeat [structural motif]
    cl02533
    Location:532587
    SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
  3. XM_011515817.2XP_011514119.1  ankyrin repeat and SOCS box protein 15 isoform X2

    See identical proteins and their annotated locations for XP_011514119.1

    UniProtKB/Swiss-Prot
    Q8WXK1
    Conserved Domains (4) summary
    COG0666
    Location:25205
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd00204
    Location:138263
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:178207
    ANK; ANK repeat [structural motif]
    cl02533
    Location:532587
    SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
  4. XM_005250146.4XP_005250203.1  ankyrin repeat and SOCS box protein 15 isoform X2

    See identical proteins and their annotated locations for XP_005250203.1

    UniProtKB/Swiss-Prot
    Q8WXK1
    Conserved Domains (4) summary
    COG0666
    Location:25205
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd00204
    Location:138263
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:178207
    ANK; ANK repeat [structural motif]
    cl02533
    Location:532587
    SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
  5. XM_024446667.1XP_024302435.1  ankyrin repeat and SOCS box protein 15 isoform X4

    Conserved Domains (3) summary
    cd00204
    Location:125243
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd03731
    Location:479534
    SOCS_ASB15; SOCS (suppressors of cytokine signaling) box of ASB15-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Human ASB15 is expressed predominantly in skeletal muscle and participates in the regulation of ...
    sd00045
    Location:125154
    ANK; ANK repeat [structural motif]
  6. XM_011515820.2XP_011514122.1  ankyrin repeat and SOCS box protein 15 isoform X2

    See identical proteins and their annotated locations for XP_011514122.1

    UniProtKB/Swiss-Prot
    Q8WXK1
    Conserved Domains (4) summary
    COG0666
    Location:25205
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd00204
    Location:138263
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:178207
    ANK; ANK repeat [structural motif]
    cl02533
    Location:532587
    SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
  7. XM_011515818.2XP_011514120.1  ankyrin repeat and SOCS box protein 15 isoform X2

    See identical proteins and their annotated locations for XP_011514120.1

    UniProtKB/Swiss-Prot
    Q8WXK1
    Conserved Domains (4) summary
    COG0666
    Location:25205
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd00204
    Location:138263
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:178207
    ANK; ANK repeat [structural motif]
    cl02533
    Location:532587
    SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
  8. XM_011515816.2XP_011514118.1  ankyrin repeat and SOCS box protein 15 isoform X1

    Conserved Domains (4) summary
    cd00204
    Location:144269
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:121213
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:184213
    ANK; ANK repeat [structural motif]
    cl02533
    Location:538593
    SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
  9. XM_011515821.2XP_011514123.1  ankyrin repeat and SOCS box protein 15 isoform X3

    Conserved Domains (4) summary
    cd00204
    Location:131249
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:135226
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:131160
    ANK; ANK repeat [structural motif]
    cl02533
    Location:485540
    SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
  10. XM_017011756.2XP_016867245.1  ankyrin repeat and SOCS box protein 15 isoform X2

    UniProtKB/Swiss-Prot
    Q8WXK1
    Conserved Domains (4) summary
    COG0666
    Location:25205
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd00204
    Location:138263
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:178207
    ANK; ANK repeat [structural motif]
    cl02533
    Location:532587
    SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
  11. XM_017011758.1XP_016867247.1  ankyrin repeat and SOCS box protein 15 isoform X5

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