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Slc34a3 solute carrier family 34 (sodium phosphate), member 3 [ Mus musculus (house mouse) ]

Gene ID: 142681, updated on 8-Feb-2024

Summary

Official Symbol
Slc34a3provided by MGI
Official Full Name
solute carrier family 34 (sodium phosphate), member 3provided by MGI
Primary source
MGI:MGI:2159410
See related
Ensembl:ENSMUSG00000006469 AllianceGenome:MGI:2159410
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Npt2c; NptIIc; naPi-2c; Npt2c-v1
Summary
Enables sodium:phosphate symporter activity. Acts upstream of or within phosphate ion transport. Located in apical plasma membrane and brush border. Is expressed in several structures, including extraembryonic component; genitourinary system; and small intestine. Human ortholog(s) of this gene implicated in hereditary hypophosphatemic rickets with hypercalciuria. Orthologous to human SLC34A3 (solute carrier family 34 member 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward kidney adult (RPKM 74.2) See more
Orthologs
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Genomic context

See Slc34a3 in Genome Data Viewer
Location:
2 A3; 2 17.09 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (25118909..25124282, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (25228897..25234270, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene sperm tail PG rich repeat containing 3 Neighboring gene ciliary microtubule inner protein 2A Neighboring gene tubulin, beta 4B class IVB Neighboring gene STARR-seq mESC enhancer starr_03963 Neighboring gene ring finger protein 224 Neighboring gene cysteine rich tail 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

General gene information

Markers

Clone Names

  • MGC159029

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables sodium:phosphate symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables sodium:phosphate symporter activity IDA
Inferred from Direct Assay
more info
PubMed 
enables sodium:phosphate symporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables sodium:phosphate symporter activity ISO
Inferred from Sequence Orthology
more info
 
enables symporter activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in intracellular phosphate ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in intracellular phosphate ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within phosphate ion transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in phosphate ion transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within sodium ion transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in sodium ion transport ISO
Inferred from Sequence Orthology
more info
 
involved_in sodium-dependent phosphate transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in sodium-dependent phosphate transport ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in apical plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in brush border IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in brush border IDA
Inferred from Direct Assay
more info
PubMed 
located_in brush border membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in brush border membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in vesicle IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
sodium-dependent phosphate transport protein 2C
Names
Na(+)-dependent phosphate cotransporter 2C
Na(+)/Pi cotransporter 2C
sodium-phosphate cotransporter IIC
sodium/phosphate cotransporter 2C
type IIc Na+/Pi-cotransporter
type IIc NaPi-cotransporter-v1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001362748.1NP_001349677.1  sodium-dependent phosphate transport protein 2C isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AL732309
    UniProtKB/TrEMBL
    A0A0D5ZYC4
    Conserved Domains (1) summary
    TIGR01013
    Location:19505
    2a58; Phosphate:Na+ Symporter (PNaS) Family
  2. NM_080854.3NP_543130.2  sodium-dependent phosphate transport protein 2C isoform 1

    See identical proteins and their annotated locations for NP_543130.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AL732309, BC125326
    Consensus CDS
    CCDS15754.1
    UniProtKB/Swiss-Prot
    Q05AC3, Q80SU6
    UniProtKB/TrEMBL
    A0A0D5ZYC4
    Related
    ENSMUSP00000006638.8, ENSMUST00000006638.8
    Conserved Domains (1) summary
    TIGR01013
    Location:79565
    2a58; Phosphate:Na+ Symporter (PNaS) Family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    25118909..25124282 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006497681.3XP_006497744.1  sodium-dependent phosphate transport protein 2C isoform X5

    See identical proteins and their annotated locations for XP_006497744.1

    UniProtKB/TrEMBL
    A0A0D5ZYC4
    Conserved Domains (1) summary
    TIGR01013
    Location:19505
    2a58; Phosphate:Na+ Symporter (PNaS) Family
  2. XM_006497683.3XP_006497746.1  sodium-dependent phosphate transport protein 2C isoform X5

    See identical proteins and their annotated locations for XP_006497746.1

    UniProtKB/TrEMBL
    A0A0D5ZYC4
    Conserved Domains (1) summary
    TIGR01013
    Location:19505
    2a58; Phosphate:Na+ Symporter (PNaS) Family
  3. XM_006497679.2XP_006497742.1  sodium-dependent phosphate transport protein 2C isoform X3

    UniProtKB/TrEMBL
    A0A0D5ZYC4
    Conserved Domains (1) summary
    TIGR01013
    Location:72558
    2a58; Phosphate:Na+ Symporter (PNaS) Family
  4. XM_006497677.2XP_006497740.1  sodium-dependent phosphate transport protein 2C isoform X2

    See identical proteins and their annotated locations for XP_006497740.1

    UniProtKB/Swiss-Prot
    Q05AC3, Q80SU6
    UniProtKB/TrEMBL
    A0A0D5ZYC4
    Conserved Domains (1) summary
    TIGR01013
    Location:79565
    2a58; Phosphate:Na+ Symporter (PNaS) Family
  5. XM_011239018.2XP_011237320.1  sodium-dependent phosphate transport protein 2C isoform X4

    UniProtKB/TrEMBL
    A0A0D5ZYC4
    Conserved Domains (1) summary
    TIGR01013
    Location:87543
    2a58; Phosphate:Na+ Symporter (PNaS) Family
  6. XM_011239017.2XP_011237319.1  sodium-dependent phosphate transport protein 2C isoform X1

    UniProtKB/TrEMBL
    A0A0D5ZYC4
    Conserved Domains (1) summary
    TIGR01013
    Location:87573
    2a58; Phosphate:Na+ Symporter (PNaS) Family
  7. XM_006497678.2XP_006497741.1  sodium-dependent phosphate transport protein 2C isoform X2

    See identical proteins and their annotated locations for XP_006497741.1

    UniProtKB/Swiss-Prot
    Q05AC3, Q80SU6
    UniProtKB/TrEMBL
    A0A0D5ZYC4
    Conserved Domains (1) summary
    TIGR01013
    Location:79565
    2a58; Phosphate:Na+ Symporter (PNaS) Family
  8. XM_017315536.2XP_017171025.1  sodium-dependent phosphate transport protein 2C isoform X1

    UniProtKB/TrEMBL
    A0A0D5ZYC4
    Conserved Domains (1) summary
    TIGR01013
    Location:87573
    2a58; Phosphate:Na+ Symporter (PNaS) Family
  9. XM_017315541.2XP_017171030.1  sodium-dependent phosphate transport protein 2C isoform X5

    UniProtKB/TrEMBL
    A0A0D5ZYC4
    Conserved Domains (1) summary
    TIGR01013
    Location:19505
    2a58; Phosphate:Na+ Symporter (PNaS) Family