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DUSP19 dual specificity phosphatase 19 [ Homo sapiens (human) ]

Gene ID: 142679, updated on 10-Oct-2019

Summary

Official Symbol
DUSP19provided by HGNC
Official Full Name
dual specificity phosphatase 19provided by HGNC
Primary source
HGNC:HGNC:18894
See related
Ensembl:ENSG00000162999 MIM:611437
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SKRP1; DUSP17; LMWDSP3; TS-DSP1
Summary
Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. They have been implicated as major modulators of critical signaling pathways. DUSP19 contains a variation of the consensus DUSP C-terminal catalytic domain, with the last serine residue replaced by alanine, and lacks the N-terminal CH2 domain found in the MKP (mitogen-activated protein kinase phosphatase) class of DUSPs (see MIM 600714) (summary by Patterson et al., 2009 [PubMed 19228121]).[supplied by OMIM, Dec 2009]
Expression
Low expression observed in reference dataset See more
Orthologs

Genomic context

See DUSP19 in Genome Data Viewer
Location:
2q32.1
Exon count:
4
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (183078747..183100008)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (183943287..183964736)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene NCK associated protein 1 Neighboring gene keratin 8 pseudogene 10 Neighboring gene nucleoporin 35 Neighboring gene uncharacterized LOC105373774

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC138210

Gene Ontology Provided by GOA

Function Evidence Code Pubs
JUN kinase phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
MAP-kinase scaffold activity ISS
Inferred from Sequence or Structural Similarity
more info
 
mitogen-activated protein kinase kinase kinase binding ISS
Inferred from Sequence or Structural Similarity
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activator activity ISS
Inferred from Sequence or Structural Similarity
more info
 
protein kinase inhibitor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
activation of protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
negative regulation of JNK cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of JUN kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of protein kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
peptidyl-tyrosine dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of JNK cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of JUN kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of MAPK cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of protein kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of MAP kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
dual specificity protein phosphatase 19
Names
SAPK pathway-regulating phosphatase 1
dual specificity phosphatase TS-DSP1
low molecular weight dual specificity phosphatase 3
protein phosphatase SKRP1
stress-activated protein kinase pathway-regulating phosphatase 1
NP_001135786.1
NP_001308448.1
NP_543152.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001142314.2NP_001135786.1  dual specificity protein phosphatase 19 isoform 2

    See identical proteins and their annotated locations for NP_001135786.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the mid coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.
    Source sequence(s)
    AB063187, AC064871, BC035000
    Consensus CDS
    CCDS46469.1
    UniProtKB/Swiss-Prot
    Q8WTR2
    Related
    ENSP00000343905.6, ENST00000342619.10
    Conserved Domains (1) summary
    cl21483
    Location:65150
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  2. NM_001321519.2NP_001308448.1  dual specificity protein phosphatase 19 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AB063186, AC064871, BX647818
    UniProtKB/Swiss-Prot
    Q8WTR2
    Conserved Domains (1) summary
    cl21483
    Location:6596
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  3. NM_080876.4NP_543152.1  dual specificity protein phosphatase 19 isoform 1

    See identical proteins and their annotated locations for NP_543152.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AB063186, AC064871, BC035000
    Consensus CDS
    CCDS2289.1
    UniProtKB/Swiss-Prot
    Q8WTR2
    Related
    ENSP00000346160.4, ENST00000354221.5
    Conserved Domains (1) summary
    cd00127
    Location:65201
    DSPc; Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or ...

RNA

  1. NR_135688.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AB063186, AC064871, BC143337

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    183078747..183100008
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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