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MIB2 mindbomb E3 ubiquitin protein ligase 2 [ Homo sapiens (human) ]

Gene ID: 142678, updated on 13-Mar-2020

Summary

Official Symbol
MIB2provided by HGNC
Official Full Name
mindbomb E3 ubiquitin protein ligase 2provided by HGNC
Primary source
HGNC:HGNC:30577
See related
Ensembl:ENSG00000197530 MIM:611141
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZZZ5; ZZANK1
Summary
The protein encoded by this gene is an E3 ubiquitin protein ligase that mediates ubiquitination of proteins in the Notch signaling pathway. The encoded protein may be a suppressor of melanoma invasion. [provided by RefSeq, Mar 2017]
Expression
Ubiquitous expression in spleen (RPKM 6.7), fat (RPKM 5.7) and 25 other tissues See more
Orthologs

Genomic context

See MIB2 in Genome Data Viewer
Location:
1p36.33
Exon count:
24
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (1613730..1630610)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (1550795..1565990)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene SSU72 homolog, RNA polymerase II CTD phosphatase Neighboring gene uncharacterized LOC105378586 Neighboring gene fibronectin type III domain containing 10 Neighboring gene matrix metallopeptidase 23B Neighboring gene cyclin dependent kinase 11B Neighboring gene solute carrier family 35 member E2B Neighboring gene ribosomal protein S7 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20648, FLJ39787, FLJ41406

Gene Ontology Provided by GOA

Function Evidence Code Pubs
actin binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
 
ubiquitin-protein transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of I-kappaB kinase/NF-kappaB signaling HMP PubMed 
protein polyubiquitination TAS
Traceable Author Statement
more info
 
protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
early endosome IEA
Inferred from Electronic Annotation
more info
 
ubiquitin ligase complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
E3 ubiquitin-protein ligase MIB2
Names
RING-type E3 ubiquitin transferase MIB2
mind bomb homolog 2
mindbomb homolog 2
novel zinc finger protein
novelzin
putative NF-kappa-B-activating protein 002N
skeletrophin
zinc finger ZZ type with ankyrin repeat domain protein 1
zinc finger, ZZ type with ankyrin repeat domain 1
NP_001164157.2
NP_001164158.2
NP_001164159.1
NP_001164160.1
NP_543151.3
XP_006710435.1
XP_011539033.1
XP_011539038.1
XP_011539039.1
XP_011539043.1
XP_011539044.1
XP_016855838.1
XP_016855839.1
XP_016855840.1
XP_016855841.1
XP_016855842.1
XP_016855843.1
XP_016855844.1
XP_016855845.1
XP_016855846.1
XP_016855847.1
XP_016855848.1
XP_016855849.1
XP_016855850.1
XP_016855851.1
XP_016855852.1
XP_016855853.1
XP_016855854.1
XP_016855855.1
XP_024309085.1
XP_024309086.1
XP_024309087.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_053090.1 RefSeqGene

    Range
    5313..20418
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001170686.2NP_001164157.2  E3 ubiquitin-protein ligase MIB2 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL691432, FO704657
    Consensus CDS
    CCDS53261.1
    Related
    ENSP00000428660.1, ENST00000520777.5
  2. NM_001170687.2NP_001164158.2  E3 ubiquitin-protein ligase MIB2 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AL691432, FO704657
    Consensus CDS
    CCDS53263.1
    Related
    ENSP00000348081.5, ENST00000355826.9
  3. NM_001170688.1NP_001164159.1  E3 ubiquitin-protein ligase MIB2 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AB076692, AL691432, BC037542, DC402226
    Consensus CDS
    CCDS53262.1
    UniProtKB/Swiss-Prot
    Q96AX9
    Related
    ENSP00000428264.1, ENST00000518681.5
    Conserved Domains (7) summary
    cd00204
    Location:513625
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd02339
    Location:204248
    ZZ_Mind_bomb; Zinc finger, ZZ type. Zinc finger present in Drosophila Mind bomb (D-mib) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Mind bomb is an E3 ubiqitin ligase that has ...
    pfam06701
    Location:127192
    MIB_HERC2; Mib_herc2
    pfam12796
    Location:519611
    Ank_2; Ankyrin repeats (3 copies)
    pfam13857
    Location:606657
    Ank_5; Ankyrin repeats (many copies)
    pfam13920
    Location:9571000
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
    sd00045
    Location:515545
    ANK; ANK repeat [structural motif]
  4. NM_001170689.2NP_001164160.1  E3 ubiquitin-protein ligase MIB2 isoform 5

    See identical proteins and their annotated locations for NP_001164160.1

    Status: REVIEWED

    Source sequence(s)
    AL691432, FO704657
    Consensus CDS
    CCDS53264.1
    UniProtKB/Swiss-Prot
    Q96AX9
    Related
    ENSP00000367984.1, ENST00000378712.5
    Conserved Domains (6) summary
    cd00204
    Location:398510
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd02339
    Location:89133
    ZZ_Mind_bomb; Zinc finger, ZZ type. Zinc finger present in Drosophila Mind bomb (D-mib) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Mind bomb is an E3 ubiqitin ligase that has ...
    pfam06701
    Location:1277
    MIB_HERC2; Mib_herc2
    pfam12796
    Location:404496
    Ank_2; Ankyrin repeats (3 copies)
    pfam13857
    Location:491542
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:400430
    ANK; ANK repeat [structural motif]
  5. NM_080875.3NP_543151.3  E3 ubiquitin-protein ligase MIB2 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL691432, FO704657
    Consensus CDS
    CCDS41224.2
    Related
    ENSP00000426103.2, ENST00000505820.6

RNA

  1. NR_033183.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL691432, FO704657
    Related
    ENST00000489635.5
  2. NR_146324.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL691432
    Related
    ENST00000463492.1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    1613730..1630610
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017000357.2XP_016855846.1  E3 ubiquitin-protein ligase MIB2 isoform X11

  2. XM_017000350.2XP_016855839.1  E3 ubiquitin-protein ligase MIB2 isoform X2

  3. XM_017000355.2XP_016855844.1  E3 ubiquitin-protein ligase MIB2 isoform X8

  4. XM_017000356.2XP_016855845.1  E3 ubiquitin-protein ligase MIB2 isoform X10

  5. XM_017000351.2XP_016855840.1  E3 ubiquitin-protein ligase MIB2 isoform X3

  6. XM_017000349.2XP_016855838.1  E3 ubiquitin-protein ligase MIB2 isoform X1

  7. XM_017000352.2XP_016855841.1  E3 ubiquitin-protein ligase MIB2 isoform X4

  8. XM_017000354.2XP_016855843.1  E3 ubiquitin-protein ligase MIB2 isoform X7

  9. XM_011540731.3XP_011539033.1  E3 ubiquitin-protein ligase MIB2 isoform X6

    Conserved Domains (7) summary
    cd00204
    Location:748860
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd02339
    Location:353397
    ZZ_Mind_bomb; Zinc finger, ZZ type. Zinc finger present in Drosophila Mind bomb (D-mib) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Mind bomb is an E3 ubiqitin ligase that has ...
    pfam06701
    Location:424488
    MIB_HERC2; Mib_herc2
    pfam12796
    Location:754846
    Ank_2; Ankyrin repeats (3 copies)
    pfam13857
    Location:841892
    Ank_5; Ankyrin repeats (many copies)
    pfam13920
    Location:12251268
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
    sd00045
    Location:750780
    ANK; ANK repeat [structural motif]
  10. XM_017000353.2XP_016855842.1  E3 ubiquitin-protein ligase MIB2 isoform X5

  11. XM_011540741.3XP_011539043.1  E3 ubiquitin-protein ligase MIB2 isoform X13

    Conserved Domains (7) summary
    cd00204
    Location:692804
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd02339
    Location:353397
    ZZ_Mind_bomb; Zinc finger, ZZ type. Zinc finger present in Drosophila Mind bomb (D-mib) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Mind bomb is an E3 ubiqitin ligase that has ...
    pfam06701
    Location:424488
    MIB_HERC2; Mib_herc2
    pfam12796
    Location:698790
    Ank_2; Ankyrin repeats (3 copies)
    pfam13857
    Location:785836
    Ank_5; Ankyrin repeats (many copies)
    pfam13920
    Location:11361179
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
    sd00045
    Location:694724
    ANK; ANK repeat [structural motif]
  12. XM_011540736.3XP_011539038.1  E3 ubiquitin-protein ligase MIB2 isoform X9

    Conserved Domains (7) summary
    cd00204
    Location:748860
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd02339
    Location:353397
    ZZ_Mind_bomb; Zinc finger, ZZ type. Zinc finger present in Drosophila Mind bomb (D-mib) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Mind bomb is an E3 ubiqitin ligase that has ...
    pfam06701
    Location:424488
    MIB_HERC2; Mib_herc2
    pfam12796
    Location:754846
    Ank_2; Ankyrin repeats (3 copies)
    pfam13857
    Location:841892
    Ank_5; Ankyrin repeats (many copies)
    pfam13920
    Location:11921235
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
    sd00045
    Location:750780
    ANK; ANK repeat [structural motif]
  13. XM_011540737.3XP_011539039.1  E3 ubiquitin-protein ligase MIB2 isoform X12

    Conserved Domains (7) summary
    cd00204
    Location:727839
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd02339
    Location:353397
    ZZ_Mind_bomb; Zinc finger, ZZ type. Zinc finger present in Drosophila Mind bomb (D-mib) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Mind bomb is an E3 ubiqitin ligase that has ...
    pfam06701
    Location:424488
    MIB_HERC2; Mib_herc2
    pfam12796
    Location:733825
    Ank_2; Ankyrin repeats (3 copies)
    pfam13857
    Location:820871
    Ank_5; Ankyrin repeats (many copies)
    pfam13920
    Location:11711214
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
    sd00045
    Location:729759
    ANK; ANK repeat [structural motif]
  14. XM_011540742.3XP_011539044.1  E3 ubiquitin-protein ligase MIB2 isoform X14

    Conserved Domains (7) summary
    cd00204
    Location:691803
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd02339
    Location:353397
    ZZ_Mind_bomb; Zinc finger, ZZ type. Zinc finger present in Drosophila Mind bomb (D-mib) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Mind bomb is an E3 ubiqitin ligase that has ...
    pfam06701
    Location:424488
    MIB_HERC2; Mib_herc2
    pfam12796
    Location:697789
    Ank_2; Ankyrin repeats (3 copies)
    pfam13857
    Location:784835
    Ank_5; Ankyrin repeats (many copies)
    pfam13920
    Location:11351178
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
    sd00045
    Location:693723
    ANK; ANK repeat [structural motif]
  15. XM_017000358.1XP_016855847.1  E3 ubiquitin-protein ligase MIB2 isoform X15

  16. XM_017000361.1XP_016855850.1  E3 ubiquitin-protein ligase MIB2 isoform X18

  17. XM_017000359.1XP_016855848.1  E3 ubiquitin-protein ligase MIB2 isoform X16

  18. XM_006710372.1XP_006710435.1  E3 ubiquitin-protein ligase MIB2 isoform X21

    Related
    ENSP00000367980.1, ENST00000378708.5
    Conserved Domains (7) summary
    cd00204
    Location:542654
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd02339
    Location:204248
    ZZ_Mind_bomb; Zinc finger, ZZ type. Zinc finger present in Drosophila Mind bomb (D-mib) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Mind bomb is an E3 ubiqitin ligase that has ...
    pfam06701
    Location:275339
    MIB_HERC2; Mib_herc2
    pfam12796
    Location:548640
    Ank_2; Ankyrin repeats (3 copies)
    pfam13857
    Location:635686
    Ank_5; Ankyrin repeats (many copies)
    pfam13920
    Location:9861029
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
    sd00045
    Location:544574
    ANK; ANK repeat [structural motif]
  19. XM_017000364.1XP_016855853.1  E3 ubiquitin-protein ligase MIB2 isoform X23

  20. XM_017000360.1XP_016855849.1  E3 ubiquitin-protein ligase MIB2 isoform X17

  21. XM_017000365.1XP_016855854.1  E3 ubiquitin-protein ligase MIB2 isoform X25

  22. XM_017000366.1XP_016855855.1  E3 ubiquitin-protein ligase MIB2 isoform X26

    Related
    ENSP00000427680.1, ENST00000514234.5
  23. XM_017000363.1XP_016855852.1  E3 ubiquitin-protein ligase MIB2 isoform X22

  24. XM_024453319.1XP_024309087.1  E3 ubiquitin-protein ligase MIB2 isoform X24

    Conserved Domains (7) summary
    COG0666
    Location:400521
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd00204
    Location:463575
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd02339
    Location:89133
    ZZ_Mind_bomb; Zinc finger, ZZ type. Zinc finger present in Drosophila Mind bomb (D-mib) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Mind bomb is an E3 ubiqitin ligase that has ...
    sd00045
    Location:465495
    ANK; ANK repeat [structural motif]
    pfam06701
    Location:160224
    MIB_HERC2; Mib_herc2
    cd16726
    Location:864924
    RING1-HC_MIB2; RING finger 1, HC subclass, found in mind bomb 2 (MIB2) and similar proteins
    cl17238
    Location:9671012
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
  25. XM_017000362.1XP_016855851.1  E3 ubiquitin-protein ligase MIB2 isoform X19

    Conserved Domains (7) summary
    COG0666
    Location:435556
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd00204
    Location:498610
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd02339
    Location:103147
    ZZ_Mind_bomb; Zinc finger, ZZ type. Zinc finger present in Drosophila Mind bomb (D-mib) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Mind bomb is an E3 ubiqitin ligase that has ...
    sd00045
    Location:500530
    ANK; ANK repeat [structural motif]
    pfam06701
    Location:174238
    MIB_HERC2; Mib_herc2
    cd16726
    Location:899959
    RING1-HC_MIB2; RING finger 1, HC subclass, found in mind bomb 2 (MIB2) and similar proteins
    cd16728
    Location:10021047
    RING2-HC_MIB2; RING finger 2, HC subclass, found in mind bomb 2 (MIB2) and similar proteins
  26. XM_024453317.1XP_024309085.1  E3 ubiquitin-protein ligase MIB2 isoform X19

    Conserved Domains (7) summary
    COG0666
    Location:435556
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd00204
    Location:498610
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd02339
    Location:103147
    ZZ_Mind_bomb; Zinc finger, ZZ type. Zinc finger present in Drosophila Mind bomb (D-mib) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Mind bomb is an E3 ubiqitin ligase that has ...
    sd00045
    Location:500530
    ANK; ANK repeat [structural motif]
    pfam06701
    Location:174238
    MIB_HERC2; Mib_herc2
    cd16726
    Location:899959
    RING1-HC_MIB2; RING finger 1, HC subclass, found in mind bomb 2 (MIB2) and similar proteins
    cd16728
    Location:10021047
    RING2-HC_MIB2; RING finger 2, HC subclass, found in mind bomb 2 (MIB2) and similar proteins
  27. XM_024453318.1XP_024309086.1  E3 ubiquitin-protein ligase MIB2 isoform X20

    Conserved Domains (7) summary
    COG0666
    Location:429550
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd00204
    Location:492604
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd02339
    Location:97141
    ZZ_Mind_bomb; Zinc finger, ZZ type. Zinc finger present in Drosophila Mind bomb (D-mib) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Mind bomb is an E3 ubiqitin ligase that has ...
    sd00045
    Location:494524
    ANK; ANK repeat [structural motif]
    pfam06701
    Location:168232
    MIB_HERC2; Mib_herc2
    cd16726
    Location:893953
    RING1-HC_MIB2; RING finger 1, HC subclass, found in mind bomb 2 (MIB2) and similar proteins
    cd16728
    Location:9961041
    RING2-HC_MIB2; RING finger 2, HC subclass, found in mind bomb 2 (MIB2) and similar proteins
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