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Aff2 AF4/FMR2 family, member 2 [ Mus musculus (house mouse) ]

Gene ID: 14266, updated on 24-Jan-2023

Summary

Official Symbol
Aff2provided by MGI
Official Full Name
AF4/FMR2 family, member 2provided by MGI
Primary source
MGI:MGI:1202294
See related
Ensembl:ENSMUSG00000031189 AllianceGenome:MGI:1202294
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Oxh; Fmr2; Ox19; FMR2P
Summary
Enables G-quadruplex RNA binding activity. Involved in regulation of RNA splicing. Acts upstream of or within learning or memory and negative regulation of gene expression. Located in nuclear speck. Is expressed in several structures, including branchial arch; heart; limb; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in X-linked intellectual developmental disorder 109. Orthologous to human AFF2 (AF4/FMR2 family member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in whole brain E14.5 (RPKM 3.1), CNS E14 (RPKM 3.0) and 15 other tissues See more
Orthologs
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Genomic context

See Aff2 in Genome Data Viewer
Location:
X; X A7.1- A7.2
Exon count:
21
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) X NC_000086.8 (68403796..68915660)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (69360190..69872054)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene quinolinate phosphoribosyltransferase pseudogene Neighboring gene nuclear encoded rRNA 5S 7 Neighboring gene ribosomal protein S6 pseudogene Neighboring gene RIKEN cDNA 1700111N16 gene Neighboring gene RIKEN cDNA 1700020N15 gene Neighboring gene iduronate 2-sulfatase

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G-quadruplex RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables G-quadruplex RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in nuclear speck IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nuclear speck IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
NOT part_of super elongation complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
AF4/FMR2 family member 2
Names
Ox19 homolog
protein FMR-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008032.3NP_032058.2  AF4/FMR2 family member 2

    See identical proteins and their annotated locations for NP_032058.2

    Status: VALIDATED

    Source sequence(s)
    AJ001549, BX294655
    Consensus CDS
    CCDS30173.1
    UniProtKB/Swiss-Prot
    B1ATW0, O55112
    Related
    ENSMUSP00000033532.7, ENSMUST00000033532.7
    Conserved Domains (1) summary
    pfam05110
    Location:191269
    AF-4; AF-4 proto-oncoprotein

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    68403796..68915660
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006527821.4XP_006527884.1  AF4/FMR2 family member 2 isoform X6

    Conserved Domains (1) summary
    pfam05110
    Location:191271
    AF-4; AF-4 proto-oncoprotein
  2. XM_030251226.1XP_030107086.1  AF4/FMR2 family member 2 isoform X7

    Conserved Domains (1) summary
    pfam05110
    Location:191265
    AF-4; AF-4 proto-oncoprotein
  3. XM_006527820.4XP_006527883.1  AF4/FMR2 family member 2 isoform X5

    Conserved Domains (1) summary
    pfam05110
    Location:191275
    AF-4; AF-4 proto-oncoprotein
  4. XM_006527816.5XP_006527879.1  AF4/FMR2 family member 2 isoform X1

    Conserved Domains (1) summary
    pfam05110
    Location:491305
    AF-4; AF-4 proto-oncoprotein
  5. XM_006527817.5XP_006527880.1  AF4/FMR2 family member 2 isoform X2

    Conserved Domains (1) summary
    pfam05110
    Location:491301
    AF-4; AF-4 proto-oncoprotein
  6. XM_006527818.5XP_006527881.1  AF4/FMR2 family member 2 isoform X3

    Conserved Domains (1) summary
    pfam05110
    Location:491299
    AF-4; AF-4 proto-oncoprotein
  7. XM_006527819.5XP_006527882.1  AF4/FMR2 family member 2 isoform X4

    Conserved Domains (1) summary
    pfam05110
    Location:491295
    AF-4; AF-4 proto-oncoprotein