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Fmod fibromodulin [ Mus musculus (house mouse) ]

Gene ID: 14264, updated on 26-Sep-2022

Summary

Official Symbol
Fmodprovided by MGI
Official Full Name
fibromodulinprovided by MGI
Primary source
MGI:MGI:1328364
See related
Ensembl:ENSMUSG00000041559 AllianceGenome:MGI:1328364
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
FM; SLRR2E
Summary
Predicted to be located in collagen-containing extracellular matrix and extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including central nervous system; heart and pericardium; intraembryonic coelom; jaw; and skeleton. Orthologous to human FMOD (fibromodulin). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in limb E14.5 (RPKM 35.1), genital fat pad adult (RPKM 32.6) and 17 other tissues See more
Orthologs
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Genomic context

See Fmod in Genome Data Viewer
Location:
1 E4; 1 58.09 cM
Exon count:
3
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (133964992..133976018)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (134037254..134048280)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene bone marrow associated noncoding RNA Neighboring gene malonyl CoA:ACP acyltransferase (mitochondrial) pseudogene Neighboring gene VISTA enhancer mm1445 Neighboring gene predicted gene, 19497 Neighboring gene Btg2R3 erythroid cis-regulatory module

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Component Evidence Code Pubs
located_in collagen-containing extracellular matrix ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
fibromodulin
Names
KSPG fibromodulin
collagen-binding 59 kDa protein
keratan sulfate proteoglycan fibromodulin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021355.4NP_067330.1  fibromodulin precursor

    See identical proteins and their annotated locations for NP_067330.1

    Status: VALIDATED

    Source sequence(s)
    AC154872, AK032302
    Consensus CDS
    CCDS15301.1
    UniProtKB/Swiss-Prot
    P50608
    UniProtKB/TrEMBL
    Q543D2
    Related
    ENSMUSP00000035489.8, ENSMUST00000048183.8
    Conserved Domains (4) summary
    smart00013
    Location:75109
    LRRNT; Leucine rich repeat N-terminal domain
    cd00116
    Location:136359
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:107130
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:176235
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    133964992..133976018
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)