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Flt3 FMS-like tyrosine kinase 3 [ Mus musculus (house mouse) ]

Gene ID: 14255, updated on 17-Feb-2019

Summary

Official Symbol
Flt3provided by MGI
Official Full Name
FMS-like tyrosine kinase 3provided by MGI
Primary source
MGI:MGI:95559
See related
Ensembl:ENSMUSG00000042817
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Flk2; Ly72; wmfl; CD135; Flk-2; Flt-3; B230315G04
Expression
Biased expression in cerebellum adult (RPKM 4.3), spleen adult (RPKM 2.2) and 14 other tissues See more
Orthologs

Genomic context

See Flt3 in Genome Data Viewer
Location:
5 86.88 cM; 5 G3
Exon count:
26
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 5 NC_000071.6 (147330741..147400489, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (148142317..148212065, complement)

Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5) decarboxylase Neighboring gene predicted gene, 29778 Neighboring gene uncharacterized LOC108169082 Neighboring gene predicted gene, 29793 Neighboring gene microtubule-associated protein 1 light chain 3 pseudogene 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC124377, MGC124378

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
cytokine receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
glucocorticoid receptor binding ISO
Inferred from Sequence Orthology
more info
 
kinase activity IEA
Inferred from Electronic Annotation
more info
 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol 3-kinase binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein self-association ISO
Inferred from Sequence Orthology
more info
 
protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
transmembrane receptor protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
B cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
B cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
antigen processing and presentation IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
cellular response to cytokine stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to virus IMP
Inferred from Mutant Phenotype
more info
PubMed 
common myeloid progenitor cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
cytokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytokine-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
dendritic cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
dendritic cell homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
hematopoietic progenitor cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
hemopoiesis ISO
Inferred from Sequence Orthology
more info
PubMed 
homeostasis of number of cells within a tissue IGI
Inferred from Genetic Interaction
more info
PubMed 
homeostasis of number of cells within a tissue IMP
Inferred from Mutant Phenotype
more info
PubMed 
leukocyte differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
leukocyte homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
lymph node development IMP
Inferred from Mutant Phenotype
more info
PubMed 
lymphocyte differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lymphocyte differentiation IDA
Inferred from Direct Assay
more info
PubMed 
lymphocyte proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
lymphoid progenitor cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
myeloid progenitor cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
myeloid progenitor cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of B cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of interleukin-6 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of tumor necrosis factor production IMP
Inferred from Mutant Phenotype
more info
PubMed 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of ERK1 and ERK2 cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of interferon-alpha production IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of interferon-alpha secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of interferon-gamma production IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of interferon-gamma secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of interleukin-12 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of interleukin-12 secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein phosphorylation IGI
Inferred from Genetic Interaction
more info
PubMed 
post-embryonic development IGI
Inferred from Genetic Interaction
more info
PubMed 
pro-B cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
pro-T cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
spleen development IGI
Inferred from Genetic Interaction
more info
PubMed 
transmembrane receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
membrane IEA
Inferred from Electronic Annotation
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 
protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
receptor-type tyrosine-protein kinase FLT3
Names
FL cytokine receptor
fetal liver kinase 2
tyrosine-protein kinase FLT3
tyrosine-protein kinase receptor flk-2
NP_034359.2
XP_006504867.1
XP_006504868.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010229.2NP_034359.2  receptor-type tyrosine-protein kinase FLT3 precursor

    See identical proteins and their annotated locations for NP_034359.2

    Status: VALIDATED

    Source sequence(s)
    AK149292, AK163640, X59398
    Consensus CDS
    CCDS39400.1
    UniProtKB/Swiss-Prot
    Q00342
    UniProtKB/TrEMBL
    Q3TQF1, Q3UEW6
    Related
    ENSMUSP00000039041.8, ENSMUST00000049324.12
    Conserved Domains (3) summary
    pfam00047
    Location:256346
    ig; Immunoglobulin domain
    pfam07714
    Location:611946
    Pkinase_Tyr; Protein tyrosine kinase
    cl21453
    Location:573950
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000071.6 Reference GRCm38.p4 C57BL/6J

    Range
    147330741..147400489 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006504805.3XP_006504868.1  receptor-type tyrosine-protein kinase FLT3 isoform X2

    Conserved Domains (2) summary
    pfam07714
    Location:181516
    Pkinase_Tyr; Protein tyrosine kinase
    cl21453
    Location:143520
    PKc_like; Protein Kinases, catalytic domain
  2. XM_006504804.3XP_006504867.1  receptor-type tyrosine-protein kinase FLT3 isoform X1

    Conserved Domains (2) summary
    pfam07714
    Location:233568
    Pkinase_Tyr; Protein tyrosine kinase
    cl21453
    Location:195572
    PKc_like; Protein Kinases, catalytic domain
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