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Flt3 FMS-like tyrosine kinase 3 [ Mus musculus (house mouse) ]

Gene ID: 14255, updated on 26-Jun-2024

Summary

Official Symbol
Flt3provided by MGI
Official Full Name
FMS-like tyrosine kinase 3provided by MGI
Primary source
MGI:MGI:95559
See related
Ensembl:ENSMUSG00000042817 AllianceGenome:MGI:95559
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Flk2; Ly72; wmfl; CD135; Flk-2; Flt-3; B230315G04
Summary
Enables several functions, including phosphatidylinositol 3-kinase binding activity; protein tyrosine kinase activity; and ubiquitin protein ligase binding activity. Involved in several processes, including common myeloid progenitor cell proliferation; hemopoiesis; and lymphocyte proliferation. Acts upstream of or within several processes, including dendritic cell homeostasis; hematopoietic or lymphoid organ development; and regulation of cytokine production. Located in external side of plasma membrane. Is expressed in several structures, including brain; dorsal aorta; immune system; reproductive system; and spinal cord. Used to study acute myeloid leukemia and juvenile myelomonocytic leukemia. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia; acute myeloid leukemia; colorectal adenocarcinoma; hepatocellular carcinoma; and prostate cancer. Orthologous to human FLT3 (fms related receptor tyrosine kinase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cerebellum adult (RPKM 4.3), spleen adult (RPKM 2.2) and 14 other tissues See more
Orthologs
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Genomic context

See Flt3 in Genome Data Viewer
Location:
5 86.88 cM; 5 G3
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (147267551..147337299, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (147330741..147400489, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5) decarboxylase Neighboring gene STARR-positive B cell enhancer ABC_E6407 Neighboring gene predicted gene, 29778 Neighboring gene STARR-positive B cell enhancer ABC_E3633 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:148151145-148151254 Neighboring gene STARR-positive B cell enhancer ABC_E1062 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:148170205-148170388 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:148178026-148178258 Neighboring gene STARR-positive B cell enhancer ABC_E6408 Neighboring gene predicted gene, 26597 Neighboring gene predicted gene, 29793 Neighboring gene microtubule-associated protein 1 light chain 3 pseudogene 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC124377, MGC124378

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables cytokine receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables growth factor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables nuclear glucocorticoid receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphatidylinositol 3-kinase binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables transmembrane receptor protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in B cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in B cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within antigen processing and presentation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell surface receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cellular response to cytokine stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cellular response to virus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in common myeloid progenitor cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cytokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cytokine-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in dendritic cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within dendritic cell homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within hemopoiesis ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within homeostasis of number of cells within a tissue IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within homeostasis of number of cells within a tissue IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in leukocyte homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lymph node development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lymphocyte differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in lymphocyte proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lymphoid progenitor cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in multicellular organism development IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within myeloid progenitor cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within myeloid progenitor cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in myeloid progenitor cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of B cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of interleukin-6 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of tumor necrosis factor production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of interferon-alpha production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of interleukin-12 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within positive regulation of multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of protein phosphorylation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of type II interferon production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within post-embryonic development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within pro-B cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in pro-B cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within pro-T cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of protein phosphorylation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within spleen development IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
receptor-type tyrosine-protein kinase FLT3
Names
FL cytokine receptor
fetal liver kinase 2
tyrosine-protein kinase FLT3
tyrosine-protein kinase receptor flk-2
NP_034359.2
XP_006504867.1
XP_006504868.1
XP_030109990.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010229.2NP_034359.2  receptor-type tyrosine-protein kinase FLT3 precursor

    See identical proteins and their annotated locations for NP_034359.2

    Status: VALIDATED

    Source sequence(s)
    AK149292, AK163640, X59398
    Consensus CDS
    CCDS39400.1
    UniProtKB/Swiss-Prot
    Q00342
    UniProtKB/TrEMBL
    Q3UEW6
    Related
    ENSMUSP00000039041.9, ENSMUST00000049324.13
    Conserved Domains (3) summary
    pfam00047
    Location:256346
    ig; Immunoglobulin domain
    pfam07714
    Location:611946
    Pkinase_Tyr; Protein tyrosine kinase
    cl21453
    Location:573950
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    147267551..147337299 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030254130.1XP_030109990.1  receptor-type tyrosine-protein kinase FLT3 isoform X1

    Conserved Domains (2) summary
    cl21453
    Location:195572
    PKc_like; Protein Kinases, catalytic domain
    cl28897
    Location:113208
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  2. XM_006504805.4XP_006504868.1  receptor-type tyrosine-protein kinase FLT3 isoform X2

    Conserved Domains (2) summary
    cl21453
    Location:143520
    PKc_like; Protein Kinases, catalytic domain
    cl28897
    Location:61156
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  3. XM_006504804.4XP_006504867.1  receptor-type tyrosine-protein kinase FLT3 isoform X1

    Conserved Domains (2) summary
    cl21453
    Location:195572
    PKc_like; Protein Kinases, catalytic domain
    cl28897
    Location:113208
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily