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orf1ab 1A polyprotein;1AB polyprotein [ Middle East respiratory syndrome-related coronavirus ]

Gene ID: 14254602, updated on 6-Jun-2021

Summary

Gene symbol
orf1ab
Gene description
1A polyprotein;1AB polyprotein
Locus tag
G128_gp01
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Middle East respiratory syndrome-related coronavirus (strain: HCoV-EMC, isolate: HCoV-EMC/2012, nat-host: Homo sapiens)
Lineage
Viruses; Riboviria; Orthornavirae; Pisuviricota; Pisoniviricetes; Nidovirales; Cornidovirineae; Coronaviridae; Orthocoronavirinae; Betacoronavirus; Merbecovirus
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Genomic context

Sequence:
NC_019843.3 (279..21514)

NC_019843.3Genomic Context describing neighboring genes Neighboring gene spike protein Neighboring gene NS3 protein Neighboring gene NS4A protein Neighboring gene NS4B protein

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General protein information

Preferred Names
1A polyprotein;1AB polyprotein
Names
nsp1 protein
nsp2 protein
nsp3 protein
nsp4 protein
nsp5 protein
nsp6 protein
nsp7 protein
nsp8 protein
nsp9 protein
nsp10 protein
RNA-dependent RNA polymerase
Hel
ExoN
NendoU
2'-O-methyltransferase
nsp11 protein
nsp1 protein
nsp2 protein
nsp3 protein
nsp4 protein
nsp5 protein
nsp6 protein
nsp7 protein
nsp8 protein
nsp9 protein
nsp10 protein

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_019843.3 Reference assembly

    Range
    279..21514
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_009047202.1 1AB polyprotein [Middle East respiratory syndrome-related coronavirus]

    See identical proteins and their annotated locations for YP_009047202.1

    Status: PROVISIONAL

    Conserved Domains (16) summary
    pfam11633
    Location:12631398
    SUD-M; Single-stranded poly(A) binding domain
    COG1112
    Location:56575899
    DNA2; Superfamily I DNA and/or RNA helicase [Replication, recombination and repair]
    pfam01661
    Location:11431243
    Macro; Macro domain
    pfam05409
    Location:32763553
    Peptidase_C30; Coronavirus endopeptidase C30
    pfam06460
    Location:67777072
    NSP13; Coronavirus NSP13
    pfam06471
    Location:59126499
    NSP11; NSP11
    pfam06478
    Location:43924744
    Corona_RPol_N; Coronavirus RPol N-terminus
    pfam08710
    Location:41284237
    nsp9; nsp9 replicase
    pfam08715
    Location:14841800
    Viral_protease; Papain like viral protease
    pfam08716
    Location:38463928
    nsp7; nsp7 replicase
    pfam08717
    Location:39324127
    nsp8; nsp8 replicase
    pfam09401
    Location:42494368
    NSP10; RNA synthesis protein NSP10
    pfam13245
    Location:55885629
    AAA_19; Part of AAA domain
    pfam16251
    Location:18311952
    NAR; Nucleic acid-binding domain (NAR)
    pfam16348
    Location:31603245
    Corona_NSP4_C; Coronavirus nonstructural protein 4 C-terminus
    cl22977
    Location:57375885
    UvrD_C_2; UvrD-like helicase C-terminal domain
  2. YP_009047213.1 nsp1 protein

    Conserved Domains (1) summary
    cd21878
    Location:23190
    MERS-CoV-like_Nsp1; non-structural protein 1 from Middle East respiratory syndrome-related coronavirus and betacoronavirus in the C lineage
  3. YP_009047214.1 nsp2 protein

  4. YP_009047215.1 nsp3 protein

    Conserved Domains (4) summary
    pfam11633
    Location:410545
    SUD-M; Single-stranded poly(A) binding domain
    pfam01661
    Location:290390
    Macro; Macro domain
    pfam08715
    Location:631947
    Viral_protease; Papain like viral protease
    pfam16251
    Location:9781099
    NAR; Nucleic acid-binding domain (NAR)
  5. YP_009047216.1 nsp4 protein

    Conserved Domains (1) summary
    pfam16348
    Location:420505
    Corona_NSP4_C; Coronavirus nonstructural protein 4 C-terminus
  6. YP_009047217.1 nsp5 protein

    Conserved Domains (1) summary
    cd21666
    Location:4300
    betaCoV_Nsp5_Mpro; betacoronavirus non-structural protein 5, also called Main protease (Mpro)
  7. YP_009047218.1 nsp6 protein

    Conserved Domains (1) summary
    cd21560
    Location:1292
    betaCoV-Nsp6; betacoronavirus non-structural protein 6
  8. YP_009047219.1 nsp7 protein

    Conserved Domains (1) summary
    cd21827
    Location:183
    betaCoV_Nsp7; betacoronavirus non-structural protein 7
  9. YP_009047220.1 nsp8 protein

    Conserved Domains (1) summary
    cd21831
    Location:4199
    betaCoV_Nsp8; betacoronavirus non-structural protein 8
  10. YP_009047221.1 nsp9 protein

    Conserved Domains (1) summary
    cd21898
    Location:1110
    betaCoV_Nsp9; betacoronavirus non-structural protein 9
  11. YP_009047222.1 nsp10 protein

    Conserved Domains (1) summary
    cd21901
    Location:1131
    alpha_betaCoV_Nsp10; alphacoronavirus and betacoronavirus non-structural protein 14
  12. YP_009047223.1 RNA-dependent RNA polymerase

    Conserved Domains (1) summary
    pfam06478
    Location:15367
    Corona_RPol_N; Coronavirus RPol N-terminus
  13. YP_009047224.1 Hel

    Conserved Domains (3) summary
    COG1112
    Location:347589
    DNA2; Superfamily I DNA and/or RNA helicase [Replication, recombination and repair]
    cl21455
    Location:277407
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    cl22977
    Location:427575
    UvrD_C_2; UvrD-like helicase C-terminal domain
  14. YP_009047225.1 ExoN

    Conserved Domains (1) summary
    cd21659
    Location:5522
    betaCoV_Nsp14; nonstructural protein 14 of betacoronavirus
  15. YP_009047226.1 NendoU

    Conserved Domains (1) summary
    pfam06471
    Location:167
    NSP11; NSP11
  16. YP_009047227.1 2'-O-methyltransferase

    Conserved Domains (1) summary
    pfam06460
    Location:2297
    NSP13; Coronavirus NSP13
  17. YP_009047203.1 1A polyprotein [Middle East respiratory syndrome-related coronavirus]

    See identical proteins and their annotated locations for YP_009047203.1

    Status: PROVISIONAL

    Conserved Domains (10) summary
    pfam11633
    Location:12631398
    SUD-M; Single-stranded poly(A) binding domain
    pfam01661
    Location:11431243
    Macro; Macro domain
    pfam05409
    Location:32763553
    Peptidase_C30; Coronavirus endopeptidase C30
    pfam08710
    Location:41284237
    nsp9; nsp9 replicase
    pfam08715
    Location:14841800
    Viral_protease; Papain like viral protease
    pfam08716
    Location:38463928
    nsp7; nsp7 replicase
    pfam08717
    Location:39324127
    nsp8; nsp8 replicase
    pfam09401
    Location:42494368
    NSP10; RNA synthesis protein NSP10
    pfam16251
    Location:18311952
    NAR; Nucleic acid-binding domain (NAR)
    pfam16348
    Location:31603245
    Corona_NSP4_C; Coronavirus nonstructural protein 4 C-terminus
  18. YP_009047228.1 nsp11 protein

  19. YP_009047229.1 nsp1 protein

    Conserved Domains (1) summary
    cd21878
    Location:23190
    MERS-CoV-like_Nsp1; non-structural protein 1 from Middle East respiratory syndrome-related coronavirus and betacoronavirus in the C lineage
  20. YP_009047230.1 nsp2 protein

  21. YP_009047231.1 nsp3 protein

    Conserved Domains (4) summary
    pfam11633
    Location:410545
    SUD-M; Single-stranded poly(A) binding domain
    pfam01661
    Location:290390
    Macro; Macro domain
    pfam08715
    Location:631947
    Viral_protease; Papain like viral protease
    pfam16251
    Location:9781099
    NAR; Nucleic acid-binding domain (NAR)
  22. YP_009047232.1 nsp4 protein

    Conserved Domains (1) summary
    pfam16348
    Location:420505
    Corona_NSP4_C; Coronavirus nonstructural protein 4 C-terminus
  23. YP_009047233.1 nsp5 protein

    Conserved Domains (1) summary
    cd21666
    Location:4300
    betaCoV_Nsp5_Mpro; betacoronavirus non-structural protein 5, also called Main protease (Mpro)
  24. YP_009047234.1 nsp6 protein

    Conserved Domains (1) summary
    cd21560
    Location:1292
    betaCoV-Nsp6; betacoronavirus non-structural protein 6
  25. YP_009047235.1 nsp7 protein

    Conserved Domains (1) summary
    cd21827
    Location:183
    betaCoV_Nsp7; betacoronavirus non-structural protein 7
  26. YP_009047236.1 nsp8 protein

    Conserved Domains (1) summary
    cd21831
    Location:4199
    betaCoV_Nsp8; betacoronavirus non-structural protein 8
  27. YP_009047237.1 nsp9 protein

    Conserved Domains (1) summary
    cd21898
    Location:1110
    betaCoV_Nsp9; betacoronavirus non-structural protein 9
  28. YP_009047238.1 nsp10 protein

    Conserved Domains (1) summary
    cd21901
    Location:1131
    alpha_betaCoV_Nsp10; alphacoronavirus and betacoronavirus non-structural protein 14
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