Flii flightless I actin binding protein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fliiprovided by MGI
Official Full Name: flightless I actin binding proteinprovided by MGI
Primary source: MGI:MGI:1342286
See related: Ensembl:ENSMUSG00000002812 AllianceGenome:MGI:1342286
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Fliih; 3632430F08Rik
Summary: This gene encodes a protein with gelsolin-like repeats and an N-terminal leucine-rich repeat domain. The protein is similar to a Drosophila protein involved in early embryogenesis and the structural organization of indirect flight muscle. This protein may act as an actin-remodelling protein as well as a transcriptional coactivator. Homozygous knockout mice show embryonic lethality. This protein may act to regulate wound repair. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]
Expression: Ubiquitous expression in colon adult (RPKM 59.4), ovary adult (RPKM 55.9) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B2; 11 37.81 cM

Exon count:: 30

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (60604969..60618089, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (60714143..60727263, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Flightless I Negatively Regulates Macrophage Surface TLR4, Delays Early Inflammation, and Impedes Wound Healing.
Title: Flightless I Negatively Regulates Macrophage Surface TLR4, Delays Early Inflammation, and Impedes Wound Healing.
Overexpression of Flii during Murine Embryonic Development Increases Symmetrical Division of Epidermal Progenitor Cells.
Title: Overexpression of Flii during Murine Embryonic Development Increases Symmetrical Division of Epidermal Progenitor Cells.
Flightless anchors IQGAP1 and R-ras to mediate cell extension formation and matrix remodeling.
Title: Flightless anchors IQGAP1 and R-ras to mediate cell extension formation and matrix remodeling.
Increasing the level of cytoskeletal protein Flightless I reduces adhesion formation in a murine digital flexor tendon model.
Title: Increasing the level of cytoskeletal protein Flightless I reduces adhesion formation in a murine digital flexor tendon model.
Flightless-I is a potential biomarker for the early detection of alcoholic liver disease.
Title: Flightless-I is a potential biomarker for the early detection of alcoholic liver disease.
In vitro analysis of the effect of Flightless I on murine tenocyte cellular functions.
Title: In vitro analysis of the effect of Flightless I on murine tenocyte cellular functions.
Attenuation of Flightless I Increases Human Pericyte Proliferation, Migration and Angiogenic Functions and Improves Healing in Murine Diabetic Wounds.
Title: Attenuation of Flightless I Increases Human Pericyte Proliferation, Migration and Angiogenic Functions and Improves Healing in Murine Diabetic Wounds.
the role of Flii in ulcerative colitis and mucosal damage
Title: Flightless I exacerbation of inflammatory responses contributes to increased colonic damage in a mouse model of dextran sulphate sodium-induced ulcerative colitis.
B-cell phosphoinositide 3-kinase adapter protein 1 (BCAP) delayed the recruitment and activation of pro-caspase-1 within the NLRP3/ASC preinflammasome through its association with Flightless-1, suggesting BCAP is a multifunctional signaling adaptor that inhibits key pathogen-sensing pathways in macrophages.
Title: The signaling adaptor BCAP inhibits NLRP3 and NLRC4 inflammasome activation in macrophages through interactions with Flightless-1.
FliI is required for the interaction of Rasgap(120) with G3BP1 to regulate R-ras activity and growth of cell extensions.
Title: The leucine-rich region of Flightless I interacts with R-ras to regulate cell extension formation.

Submit: New GeneRIF Correction See all GeneRIFs (32)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from Annotation Pipeline: 481 organisms have orthologs with human gene Flii
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables actin binding	ISO Inferred from Sequence Orthology more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables phosphatidylinositol-4,5-bisphosphate binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within actin cytoskeleton organization	TAS Traceable Author Statement more info	PubMed
involved_in actin filament severing	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within actin filament severing	TAS Traceable Author Statement more info	PubMed
involved_in actin polymerization or depolymerization	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in barbed-end actin filament capping	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within multicellular organism development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in myofibril assembly	IBA Inferred from Biological aspect of Ancestor more info	PubMed

Component	Evidence Code	Pubs
is_active_in actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in brush border	IDA Inferred from Direct Assay more info	PubMed
located_in cell junction	IEA Inferred from Electronic Annotation more info
located_in centriolar satellite	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info	PubMed

General protein information

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Preferred Names: protein flightless-1 homolog

Names: cytoskeletal actin-modulating protein; flightless I homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001302207.1 → NP_001289136.1 protein flightless-1 homolog isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. This results in isoform 2, which is shorter by one amino acid, compared to isoform 1.

Source sequence(s)

AK014400, AK049365, AW047188, BB857715, CV784480

Conserved Domains (7) summary

cd11280
Location:618 → 702

gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins

cd11288
Location:1054 → 1153

gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins

cd11290
Location:491 → 603

gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins

cd11291
Location:1164 → 1263

gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins

cd11292
Location:722 → 836

gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins

COG4886
Location:58 → 360

LRR; Leucine-rich repeat (LRR) protein [Transcription]

sd00033
Location:106 → 128

LRR_RI; leucine-rich repeat [structural motif]
NM_022009.2 → NP_071292.1 protein flightless-1 homolog isoform 1

See identical proteins and their annotated locations for NP_071292.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AK014400, AK049365, AW047188, BB857715

Consensus CDS

CCDS24795.1

UniProtKB/Swiss-Prot

Q8VI44, Q9JJ28

Related

ENSMUSP00000002889.5, ENSMUST00000002889.5

Conserved Domains (8) summary

cd11280
Location:619 → 703

gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins

cd11288
Location:1055 → 1154

gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins

cd11290
Location:492 → 604

gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins

cd11291
Location:1165 → 1264

gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins

cd11292
Location:723 → 837

gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins

cd00116
Location:89 → 352

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00033
Location:106 → 128

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:131 → 186

LRR_8; Leucine rich repeat