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Flii flightless I actin binding protein [ Mus musculus (house mouse) ]

Gene ID: 14248, updated on 14-May-2024

Summary

Official Symbol
Fliiprovided by MGI
Official Full Name
flightless I actin binding proteinprovided by MGI
Primary source
MGI:MGI:1342286
See related
Ensembl:ENSMUSG00000002812 AllianceGenome:MGI:1342286
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fliih; 3632430F08Rik
Summary
This gene encodes a protein with gelsolin-like repeats and an N-terminal leucine-rich repeat domain. The protein is similar to a Drosophila protein involved in early embryogenesis and the structural organization of indirect flight muscle. This protein may act as an actin-remodelling protein as well as a transcriptional coactivator. Homozygous knockout mice show embryonic lethality. This protein may act to regulate wound repair. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]
Expression
Ubiquitous expression in colon adult (RPKM 59.4), ovary adult (RPKM 55.9) and 28 other tissues See more
Orthologs
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Genomic context

See Flii in Genome Data Viewer
Location:
11 B2; 11 37.81 cM
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (60604969..60618089, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (60714143..60727263, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene poly(A) binding protein, cytoplasmic 4 pseudogene Neighboring gene Uba52 pseudogene Neighboring gene STARR-seq mESC enhancer starr_29656 Neighboring gene LLGL1 scribble cell polarity complex component Neighboring gene STARR-positive B cell enhancer ABC_E2991 Neighboring gene microRNA 5100 Neighboring gene mitochondrial elongation factor 2 Neighboring gene predicted gene, 23341

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (4)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables actin binding ISO
Inferred from Sequence Orthology
more info
 
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables phosphatidylinositol-4,5-bisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within actin cytoskeleton organization TAS
Traceable Author Statement
more info
PubMed 
involved_in actin filament severing IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within actin filament severing TAS
Traceable Author Statement
more info
PubMed 
involved_in actin polymerization or depolymerization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in barbed-end actin filament capping IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within multicellular organism development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in myofibril assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
 
located_in brush border IDA
Inferred from Direct Assay
more info
PubMed 
located_in centriolar satellite ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
protein flightless-1 homolog
Names
cytoskeletal actin-modulating protein
flightless I homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001302207.1NP_001289136.1  protein flightless-1 homolog isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. This results in isoform 2, which is shorter by one amino acid, compared to isoform 1.
    Source sequence(s)
    AK014400, AK049365, AW047188, BB857715, CV784480
    Conserved Domains (7) summary
    cd11280
    Location:618702
    gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
    cd11288
    Location:10541153
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:491603
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:11641263
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:722836
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    COG4886
    Location:58360
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:106128
    LRR_RI; leucine-rich repeat [structural motif]
  2. NM_022009.2NP_071292.1  protein flightless-1 homolog isoform 1

    See identical proteins and their annotated locations for NP_071292.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK014400, AK049365, AW047188, BB857715
    Consensus CDS
    CCDS24795.1
    UniProtKB/Swiss-Prot
    Q8K095, Q8VI44, Q9JJ28
    Related
    ENSMUSP00000002889.5, ENSMUST00000002889.5
    Conserved Domains (8) summary
    cd11280
    Location:619703
    gelsolin_like; Tandemly repeated domains found in gelsolin, severin, villin, and related proteins
    cd11288
    Location:10551154
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:492604
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:11651264
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:723837
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd00116
    Location:89352
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:106128
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:131186
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    60604969..60618089 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)