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Fli1 Friend leukemia integration 1 [ Mus musculus (house mouse) ]

Gene ID: 14247, updated on 8-Dec-2018

Summary

Official Symbol
Fli1provided by MGI
Official Full Name
Friend leukemia integration 1provided by MGI
Primary source
MGI:MGI:95554
See related
Ensembl:ENSMUSG00000016087
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sic1; EWSR2; Fli-1; SIC-1
Expression
Broad expression in spleen adult (RPKM 10.2), thymus adult (RPKM 7.9) and 23 other tissues See more
Orthologs

Genomic context

See Fli1 in Genome Data Viewer
Location:
9 A4; 9 17.74 cM
Exon count:
12
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 9 NC_000075.6 (32422204..32543427, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (32229793..32348953, complement)

Chromosome 9 - NC_000075.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 39317 Neighboring gene predicted gene, 31755 Neighboring gene potassium inwardly-rectifying channel, subfamily J, member 1 Neighboring gene predicted gene, 31871 Neighboring gene predicted gene, 31928

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
animal organ morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
blood circulation IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular process TAS
Traceable Author Statement
more info
PubMed 
megakaryocyte development IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytosol ISO
Inferred from Sequence Orthology
more info
 
nuclear body ISO
Inferred from Sequence Orthology
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
Friend leukemia integration 1 transcription factor
Names
retroviral integration site protein Fli-1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008026.5NP_032052.1  Friend leukemia integration 1 transcription factor

    See identical proteins and their annotated locations for NP_032052.1

    Status: VALIDATED

    Source sequence(s)
    AA183149, AC127581, AK036655, AK042111
    Consensus CDS
    CCDS40571.1
    UniProtKB/Swiss-Prot
    P26323
    UniProtKB/TrEMBL
    Q544B3, Q8BZ56
    Related
    ENSMUSP00000016231.6, ENSMUST00000016231.13
    Conserved Domains (2) summary
    cd08541
    Location:114204
    SAM_PNT-FLI-1; Sterile alpha motif (SAM)/Pointed domain of friend leukemia integration 1 transcription activator
    smart00413
    Location:280363
    ETS; erythroblast transformation specific domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000075.6 Reference GRCm38.p4 C57BL/6J

    Range
    32422204..32543427 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006510008.2XP_006510071.1  Friend leukemia integration 1 transcription factor isoform X1

    See identical proteins and their annotated locations for XP_006510071.1

    Conserved Domains (2) summary
    cd08541
    Location:81171
    SAM_PNT-FLI-1; Sterile alpha motif (SAM)/Pointed domain of friend leukemia integration 1 transcription activator
    smart00413
    Location:247330
    ETS; erythroblast transformation specific domain
  2. XM_006510009.2XP_006510072.1  Friend leukemia integration 1 transcription factor isoform X1

    See identical proteins and their annotated locations for XP_006510072.1

    Conserved Domains (2) summary
    cd08541
    Location:81171
    SAM_PNT-FLI-1; Sterile alpha motif (SAM)/Pointed domain of friend leukemia integration 1 transcription activator
    smart00413
    Location:247330
    ETS; erythroblast transformation specific domain
  3. XM_017313133.1XP_017168622.1  Friend leukemia integration 1 transcription factor isoform X1

    Conserved Domains (2) summary
    cd08541
    Location:81171
    SAM_PNT-FLI-1; Sterile alpha motif (SAM)/Pointed domain of friend leukemia integration 1 transcription activator
    smart00413
    Location:247330
    ETS; erythroblast transformation specific domain
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