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Fli1 Friend leukemia integration 1 [ Mus musculus (house mouse) ]

Gene ID: 14247, updated on 12-May-2024

Summary

Official Symbol
Fli1provided by MGI
Official Full Name
Friend leukemia integration 1provided by MGI
Primary source
MGI:MGI:95554
See related
Ensembl:ENSMUSG00000016087 AllianceGenome:MGI:95554
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sic1; EWSR2; Fli-1; SIC-1
Summary
Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including blood circulation; megakaryocyte development; and regulation of transcription, DNA-templated. Located in nucleus. Is expressed in several structures, including alimentary system; branchial arch; cardiovascular system; genitourinary system; and nervous system. Used to study systemic scleroderma. Human ortholog(s) of this gene implicated in blood platelet disease and thrombocytopenia. Orthologous to human FLI1 (Fli-1 proto-oncogene, ETS transcription factor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in spleen adult (RPKM 10.2), thymus adult (RPKM 7.9) and 23 other tissues See more
Orthologs
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Genomic context

See Fli1 in Genome Data Viewer
Location:
9 A4; 9 17.74 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (32333500..32454292, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (32422204..32543432, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr9:32157923-32158223 Neighboring gene STARR-positive B cell enhancer ABC_E38 Neighboring gene STARR-seq mESC enhancer starr_23730 Neighboring gene predicted gene, 39317 Neighboring gene STARR-seq mESC enhancer starr_23731 Neighboring gene predicted gene, 31755 Neighboring gene potassium inwardly-rectifying channel, subfamily J, member 1 Neighboring gene predicted gene, 22060 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:32303340-32303523 Neighboring gene STARR-seq mESC enhancer starr_23734 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:32313794-32313977 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:32317387-32317633 Neighboring gene STARR-positive B cell enhancer mm9_chr9:32323433-32323734 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:32325957-32326225 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:32345741-32346052 Neighboring gene STARR-positive B cell enhancer ABC_E6720 Neighboring gene STARR-positive B cell enhancer mm9_chr9:32397521-32397822 Neighboring gene STARR-positive B cell enhancer mm9_chr9:32399361-32399662 Neighboring gene STARR-positive B cell enhancer ABC_E2885 Neighboring gene predicted gene, 31871 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:32423579-32423876 Neighboring gene predicted gene, 31928

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (11)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
Friend leukemia integration 1 transcription factor
Names
retroviral integration site protein Fli-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001410251.1NP_001397180.1  Friend leukemia integration 1 transcription factor isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC127581, AC141646
  2. NM_001410252.1NP_001397181.1  Friend leukemia integration 1 transcription factor isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC127581, AC141646
  3. NM_008026.6NP_032052.1  Friend leukemia integration 1 transcription factor isoform 1

    See identical proteins and their annotated locations for NP_032052.1

    Status: VALIDATED

    Source sequence(s)
    AC127581, AC141646
    Consensus CDS
    CCDS40571.1
    UniProtKB/Swiss-Prot
    P26323
    UniProtKB/TrEMBL
    Q544B3, Q8BZ56
    Related
    ENSMUSP00000016231.7, ENSMUST00000016231.14
    Conserved Domains (2) summary
    cd08541
    Location:114204
    SAM_PNT-FLI-1; Sterile alpha motif (SAM)/Pointed domain of friend leukemia integration 1 transcription activator
    smart00413
    Location:280363
    ETS; erythroblast transformation specific domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    32333500..32454292 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006510009.4XP_006510072.1  Friend leukemia integration 1 transcription factor isoform X2

    See identical proteins and their annotated locations for XP_006510072.1

    UniProtKB/TrEMBL
    Q8BZ56
    Conserved Domains (2) summary
    cd08541
    Location:81171
    SAM_PNT-FLI-1; Sterile alpha motif (SAM)/Pointed domain of friend leukemia integration 1 transcription activator
    smart00413
    Location:247330
    ETS; erythroblast transformation specific domain