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Fhl1 four and a half LIM domains 1 [ Mus musculus (house mouse) ]

Gene ID: 14199, updated on 12-Aug-2018

Summary

Official Symbol
Fhl1provided by MGI
Official Full Name
four and a half LIM domains 1provided by MGI
Primary source
MGI:MGI:1298387
See related
Ensembl:ENSMUSG00000023092 Vega:OTTMUSG00000017580
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
KyoT; SLIM; FHL-1; SLIM-1; RAM14-1
Expression
Broad expression in bladder adult (RPKM 335.4), lung adult (RPKM 134.7) and 17 other tissues See more
Orthologs

Genomic context

See Fhl1 in Genome Data Viewer
Location:
X; X A6
Exon count:
14
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) X NC_000086.7 (56731720..56793346)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) X NC_000086.6 (53984964..54046523)

Chromosome X - NC_000086.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39515 Neighboring gene predicted gene, 36289 Neighboring gene MAP7 domain containing 3 Neighboring gene adhesion G protein-coupled receptor G4

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

  • Delta-Notch Signaling Pathway, organism-specific biosystem (from WikiPathways)
    Delta-Notch Signaling Pathway, organism-specific biosystemThere are 4 Notch receptors in humans (Notch 1-4) that bind to a family of 5 ligands (Jagged 1 and 2 and Delta-like 1-3). The Notch receptors are expressed on the cell surface as heterodimeric protei...
  • Jak-STAT signaling pathway, organism-specific biosystem (from KEGG)
    Jak-STAT signaling pathway, organism-specific biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
  • Jak-STAT signaling pathway, conserved biosystem (from KEGG)
    Jak-STAT signaling pathway, conserved biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
ion channel binding ISO
Inferred from Sequence Orthology
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of G1/S transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
negative regulation of G2/M transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell growth ISO
Inferred from Sequence Orthology
more info
 
positive regulation of potassium ion transport ISO
Inferred from Sequence Orthology
more info
 
regulation of membrane depolarization ISO
Inferred from Sequence Orthology
more info
 
regulation of potassium ion transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
cytosol ISO
Inferred from Sequence Orthology
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
four and a half LIM domains protein 1
Names
RBP-associated molecule 14-1
skeletal muscle LIM-protein 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001077361.1NP_001070829.1  four and a half LIM domains protein 1 isoform 1

    See identical proteins and their annotated locations for NP_001070829.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK158966, AL671998
    Consensus CDS
    CCDS40981.1
    UniProtKB/TrEMBL
    A2AEY2
    Related
    ENSMUSP00000110417.2, OTTMUSP00000019202, ENSMUST00000114769.8, OTTMUST00000042746
    Conserved Domains (4) summary
    cd09344
    Location:4093
    LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1
    cd09424
    Location:101158
    LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)
    cd09429
    Location:162214
    LIM3_FHL1; The third LIM domain of Four and a half LIM domains protein 1 (FHL1)
    cl02475
    Location:533
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
  2. NM_001077362.2NP_001070830.1  four and a half LIM domains protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001070830.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents the use of an alternate promoter, differs in the 5' and 3' UTRs and lacks an exon in the 3' coding region resulting in a translational frameshift compared to variant 1. The encoded protein (isoform 2) has a longer N-terminus, a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AL671998
    Consensus CDS
    CCDS40980.1
    UniProtKB/Swiss-Prot
    P97447
    UniProtKB/TrEMBL
    A2AEX8
    Related
    ENSMUSP00000110420.2, OTTMUSP00000019204, ENSMUST00000114772.8, OTTMUST00000042748
    Conserved Domains (5) summary
    cd09344
    Location:56109
    LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1
    cd09348
    Location:233296
    LIM4_FHL1; The fourth LIM domain of Four and a half LIM domains protein 1 (FHL1)
    cd09424
    Location:117174
    LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)
    cd09429
    Location:178230
    LIM3_FHL1; The third LIM domain of Four and a half LIM domains protein 1 (FHL1)
    cl02475
    Location:2149
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
  3. NM_001287800.1NP_001274729.1  four and a half LIM domains protein 1 isoform 3

    See identical proteins and their annotated locations for NP_001274729.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) represents the use of an alternate promoter, differs in the 5' and 3' UTRs and lacks an exon in the 3' coding region resulting in a translational frameshift compared to variant 1. The encoded protein (isoform 3, also known as KyoT1) has a distinct C-terminus and is shorter than isoform 1. Variants 3 and 4 encode the same protein.
    Source sequence(s)
    AL671998
    Consensus CDS
    CCDS30148.1
    UniProtKB/Swiss-Prot
    P97447
    Related
    ENSMUSP00000110421.3, OTTMUSP00000019293, ENSMUST00000114773.9, OTTMUST00000042910
    Conserved Domains (5) summary
    cd09344
    Location:4093
    LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1
    cd09348
    Location:217280
    LIM4_FHL1; The fourth LIM domain of Four and a half LIM domains protein 1 (FHL1)
    cd09424
    Location:101158
    LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)
    cd09429
    Location:162214
    LIM3_FHL1; The third LIM domain of Four and a half LIM domains protein 1 (FHL1)
    cl02475
    Location:533
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
  4. NM_010211.3NP_034341.2  four and a half LIM domains protein 1 isoform 3

    See identical proteins and their annotated locations for NP_034341.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' and 3' UTRs and lacks an exon in the 3' coding region resulting in a translational frameshift compared to variant 1. The encoded protein (isoform 3, also known as KyoT1) has a distinct C-terminus and is shorter than isoform 1. Variants 3 and 4 encode the same protein.
    Source sequence(s)
    AL671998
    Consensus CDS
    CCDS30148.1
    UniProtKB/Swiss-Prot
    P97447
    Related
    ENSMUSP00000023854.3, OTTMUSP00000019201, ENSMUST00000023854.9, OTTMUST00000042745
    Conserved Domains (5) summary
    cd09344
    Location:4093
    LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1
    cd09348
    Location:217280
    LIM4_FHL1; The fourth LIM domain of Four and a half LIM domains protein 1 (FHL1)
    cd09424
    Location:101158
    LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)
    cd09429
    Location:162214
    LIM3_FHL1; The third LIM domain of Four and a half LIM domains protein 1 (FHL1)
    cl02475
    Location:533
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000086.7 Reference GRCm38.p4 C57BL/6J

    Range
    56731720..56793346
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006527803.1XP_006527866.1  four and a half LIM domains protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006527866.1

    UniProtKB/TrEMBL
    A2AEY2
    Conserved Domains (4) summary
    cd09344
    Location:4093
    LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1
    cd09424
    Location:101158
    LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)
    cd09429
    Location:162214
    LIM3_FHL1; The third LIM domain of Four and a half LIM domains protein 1 (FHL1)
    cl02475
    Location:533
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
  2. XM_006527802.1XP_006527865.1  four and a half LIM domains protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006527865.1

    UniProtKB/TrEMBL
    A2AEY2
    Conserved Domains (4) summary
    cd09344
    Location:4093
    LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1
    cd09424
    Location:101158
    LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)
    cd09429
    Location:162214
    LIM3_FHL1; The third LIM domain of Four and a half LIM domains protein 1 (FHL1)
    cl02475
    Location:533
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
  3. XM_017318381.1XP_017173870.1  four and a half LIM domains protein 1 isoform X3

    UniProtKB/Swiss-Prot
    P97447
    Related
    ENSMUSP00000112295.1, OTTMUSP00000019203, ENSMUST00000116596.7, OTTMUST00000042747
    Conserved Domains (5) summary
    cd09344
    Location:4093
    LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1
    cd09348
    Location:217280
    LIM4_FHL1; The fourth LIM domain of Four and a half LIM domains protein 1 (FHL1)
    cd09424
    Location:101158
    LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)
    cd09429
    Location:162214
    LIM3_FHL1; The third LIM domain of Four and a half LIM domains protein 1 (FHL1)
    cl02475
    Location:533
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
  4. XM_017318382.1XP_017173871.1  four and a half LIM domains protein 1 isoform X5

    UniProtKB/Swiss-Prot
    P97447
    Conserved Domains (3) summary
    cd09344
    Location:4093
    LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1
    cd09424
    Location:101158
    LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)
    cl02475
    Location:533
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
  5. XM_006527801.1XP_006527864.1  four and a half LIM domains protein 1 isoform X2

    Conserved Domains (4) summary
    cd09344
    Location:56109
    LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1
    cd09424
    Location:117174
    LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)
    cd09429
    Location:178230
    LIM3_FHL1; The third LIM domain of Four and a half LIM domains protein 1 (FHL1)
    cl02475
    Location:2149
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
  6. XM_006527809.2XP_006527872.1  four and a half LIM domains protein 1 isoform X6

    UniProtKB/TrEMBL
    A2AEX7
    Related
    ENSMUSP00000110416.3, OTTMUSP00000019205, ENSMUST00000114768.9, OTTMUST00000042749
    Conserved Domains (3) summary
    cd09344
    Location:56109
    LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1
    cd09424
    Location:117174
    LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)
    cl02475
    Location:2149
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
  7. XM_006527805.2XP_006527868.1  four and a half LIM domains protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006527868.1

    UniProtKB/TrEMBL
    A2AEY2
    Conserved Domains (4) summary
    cd09344
    Location:4093
    LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1
    cd09424
    Location:101158
    LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)
    cd09429
    Location:162214
    LIM3_FHL1; The third LIM domain of Four and a half LIM domains protein 1 (FHL1)
    cl02475
    Location:533
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
  8. XM_006527800.3XP_006527863.2  four and a half LIM domains protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006527863.2

    UniProtKB/TrEMBL
    A2AEY2
    Conserved Domains (4) summary
    cd09344
    Location:4093
    LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1
    cd09424
    Location:101158
    LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)
    cd09429
    Location:162214
    LIM3_FHL1; The third LIM domain of Four and a half LIM domains protein 1 (FHL1)
    cl02475
    Location:533
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
  9. XM_006527808.2XP_006527871.2  four and a half LIM domains protein 1 isoform X5

    UniProtKB/Swiss-Prot
    P97447
    Conserved Domains (3) summary
    cd09344
    Location:4093
    LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1
    cd09424
    Location:101158
    LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)
    cl02475
    Location:533
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
  10. XM_006527807.2XP_006527870.2  four and a half LIM domains protein 1 isoform X4

    Related
    ENSMUSP00000116725.1, OTTMUSP00000019295, ENSMUST00000144600.7, OTTMUST00000042912
    Conserved Domains (4) summary
    cd09344
    Location:4093
    LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1
    cd09424
    Location:101158
    LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)
    cd09429
    Location:162214
    LIM3_FHL1; The third LIM domain of Four and a half LIM domains protein 1 (FHL1)
    cl02475
    Location:533
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
  11. XM_006527804.1XP_006527867.1  four and a half LIM domains protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006527867.1

    UniProtKB/TrEMBL
    A2AEY2
    Conserved Domains (4) summary
    cd09344
    Location:4093
    LIM1_FHL1; The first LIM domain of Four and a half LIM domains protein 1
    cd09424
    Location:101158
    LIM2_FHL1; The second LIM domain of Four and a half LIM domains protein 1 (FHL1)
    cd09429
    Location:162214
    LIM3_FHL1; The third LIM domain of Four and a half LIM domains protein 1 (FHL1)
    cl02475
    Location:533
    LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers
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