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Fgf7 fibroblast growth factor 7 [ Mus musculus (house mouse) ]

Gene ID: 14178, updated on 5-Jan-2023

Summary

Official Symbol
Fgf7provided by MGI
Official Full Name
fibroblast growth factor 7provided by MGI
Primary source
MGI:MGI:95521
See related
Ensembl:ENSMUSG00000027208 AllianceGenome:MGI:95521
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Kgf; Fgf5b
Summary
Predicted to enable heparin binding activity; receptor ligand activity; and type 2 fibroblast growth factor receptor binding activity. Involved in positive regulation of transcription, DNA-templated. Acts upstream of or within morphogenesis of an epithelium; positive regulation of epithelial cell proliferation; and regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling. Located in Golgi apparatus and extracellular region. Is expressed in several structures, including alimentary system; brain; embryo mesenchyme; genitourinary system; and integumental system. Orthologous to human FGF7 (fibroblast growth factor 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in bladder adult (RPKM 5.8), limb E14.5 (RPKM 2.3) and 13 other tissues See more
Orthologs
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Genomic context

See Fgf7 in Genome Data Viewer
Location:
2; 2 F1
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (125876578..125933105)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (126034658..126091185)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene COP9 signalosome subunit 2 Neighboring gene galactokinase 2 Neighboring gene family with sequence similarity 227, member B Neighboring gene predicted gene, 26496 Neighboring gene DTW domain containing 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (5)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables chemoattractant activity ISO
Inferred from Sequence Orthology
more info
 
enables fibroblast growth factor receptor binding IEA
Inferred from Electronic Annotation
more info
 
enables growth factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables growth factor activity ISO
Inferred from Sequence Orthology
more info
 
enables heparin binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables type 2 fibroblast growth factor receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables type 2 fibroblast growth factor receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in actin cytoskeleton reorganization ISO
Inferred from Sequence Orthology
more info
 
involved_in animal organ morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within branching involved in salivary gland morphogenesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of endothelial cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of epithelial cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in fibroblast growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within hair follicle morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in lung development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in lung development ISO
Inferred from Sequence Orthology
more info
 
involved_in mesenchymal cell proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of myoblast proliferation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of myoblast proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in ovarian follicle development ISO
Inferred from Sequence Orthology
more info
 
involved_in phosphatidylcholine biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in phospholipid biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of cell division IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of endothelial cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of epithelial cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within positive regulation of epithelial cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in positive regulation of epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of epithelial cell proliferation involved in lung morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of keratinocyte migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of keratinocyte proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of myoblast proliferation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of myoblast proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of peptidyl-tyrosine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein localization to cell surface ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in secretion by lung epithelial cell involved in lung growth ISO
Inferred from Sequence Orthology
more info
 
involved_in surfactant homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in wound healing ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular region IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
fibroblast growth factor 7
Names
FGF-7
HBGF-7
Keratinocyte growth factor
fibroblast growth factor 5b
heparin-binding growth factor 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008008.4NP_032034.1  fibroblast growth factor 7 precursor

    See identical proteins and their annotated locations for NP_032034.1

    Status: VALIDATED

    Source sequence(s)
    AK037172, AL845292
    Consensus CDS
    CCDS16681.1
    UniProtKB/Swiss-Prot
    P36363
    UniProtKB/TrEMBL
    Q544I6
    Related
    ENSMUSP00000069681.8, ENSMUST00000064794.14
    Conserved Domains (1) summary
    pfam00167
    Location:65189
    FGF; Fibroblast growth factor

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    125876578..125933105
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)