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Fgf3 fibroblast growth factor 3 [ Mus musculus (house mouse) ]

Gene ID: 14174, updated on 7-Aug-2018

Summary

Official Symbol
Fgf3provided by MGI
Official Full Name
fibroblast growth factor 3provided by MGI
Primary source
MGI:MGI:95517
See related
Ensembl:ENSMUSG00000031074 Vega:OTTMUSG00000031027
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fgf-3; Int-2; Int-P
Expression
Biased expression in whole brain E14.5 (RPKM 2.4), CNS E14 (RPKM 2.0) and 5 other tissues See more
Orthologs

Genomic context

See Fgf3 in Genome Data Viewer
Location:
7 F5; 7 88.85 cM
Exon count:
4
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 7 NC_000073.6 (144837957..144844447)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (152024517..152029253)

Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene anoctamin 1, calcium activated chloride channel Neighboring gene RIKEN cDNA D930030F02 gene Neighboring gene NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7 (B14.5a), pseudogene Neighboring gene fibroblast growth factor 4 Neighboring gene predicted gene, 26793

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
fibroblast growth factor receptor binding IEA
Inferred from Electronic Annotation
more info
 
growth factor activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
fibroblast growth factor receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
fibroblast growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cardiac muscle tissue development ISO
Inferred from Sequence Orthology
more info
 
organ induction IGI
Inferred from Genetic Interaction
more info
PubMed 
otic vesicle formation IGI
Inferred from Genetic Interaction
more info
PubMed 
otic vesicle formation TAS
Traceable Author Statement
more info
PubMed 
positive regulation of cell division IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
post-anal tail morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
semicircular canal morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
thymus development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
fibroblast growth factor 3
Names
HBGF-3
INT-2 proto-oncogene protein
heparin-binding growth factor 3
proto-oncogene Int-2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008007.2NP_032033.2  fibroblast growth factor 3 precursor

    See identical proteins and their annotated locations for NP_032033.2

    Status: VALIDATED

    Source sequence(s)
    BC117059, BM942045, BU923457
    Consensus CDS
    CCDS22051.1
    UniProtKB/TrEMBL
    Q0VG15
    Related
    ENSMUSP00000101518.1, OTTMUSP00000040521, ENSMUST00000105898.1, OTTMUST00000076860
    Conserved Domains (1) summary
    smart00442
    Location:44181
    FGF; Acidic and basic fibroblast growth factor family

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000073.6 Reference GRCm38.p4 C57BL/6J

    Range
    144837957..144844447
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011241980.2XP_011240282.1  fibroblast growth factor 3 isoform X1

    See identical proteins and their annotated locations for XP_011240282.1

    UniProtKB/TrEMBL
    Q0VG15
    Conserved Domains (1) summary
    smart00442
    Location:44181
    FGF; Acidic and basic fibroblast growth factor family
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