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Fgf14 fibroblast growth factor 14 [ Mus musculus (house mouse) ]

Gene ID: 14169, updated on 9-Oct-2018

Summary

Official Symbol
Fgf14provided by MGI
Official Full Name
fibroblast growth factor 14provided by MGI
Primary source
MGI:MGI:109189
See related
Ensembl:ENSMUSG00000025551 Vega:OTTMUSG00000021491
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Fhf4; FHF-4; mFHF-4(1B); Tg(tetO-MAPT*P301L)4510Kha
Expression
Biased expression in cerebellum adult (RPKM 4.3), cortex adult (RPKM 2.4) and 7 other tissues See more
Orthologs

Genomic context

See Fgf14 in Genome Data Viewer
Location:
14 E5; 14 66.18 cM
Exon count:
7
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 14 NC_000080.6 (123973845..124677667, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (124377513..125076349, complement)

Chromosome 14 - NC_000080.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 46490 Neighboring gene integrin, beta-like 1 Neighboring gene predicted gene 9308 Neighboring gene RIKEN cDNA 1700024B18 gene Neighboring gene predicted gene 15422 Neighboring gene olfactory receptor 277, pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

  • Breast cancer, organism-specific biosystem (from KEGG)
    Breast cancer, organism-specific biosystemBreast cancer is the leading cause of cancer death among women worldwide. The vast majority of breast cancers are carcinomas that originate from cells lining the milk-forming ducts of the mammary gla...
  • Breast cancer, conserved biosystem (from KEGG)
    Breast cancer, conserved biosystemBreast cancer is the leading cause of cancer death among women worldwide. The vast majority of breast cancers are carcinomas that originate from cells lining the milk-forming ducts of the mammary gla...
  • Cardiac conduction, organism-specific biosystem (from REACTOME)
    Cardiac conduction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • ESC Pluripotency Pathways, organism-specific biosystem (from WikiPathways)
    ESC Pluripotency Pathways, organism-specific biosystemThe cytokine LIF and its downstream effector STAT3 are essential for maintenance of pluripotency in mouse ES cells. The requirement for the transcription factor Oct3/4 for ES cell pluripotency is als...
  • Focal Adhesion-PI3K-Akt-mTOR-signaling pathway, organism-specific biosystem (from WikiPathways)
    Focal Adhesion-PI3K-Akt-mTOR-signaling pathway, organism-specific biosystemCell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the...
  • MAPK signaling pathway, organism-specific biosystem (from KEGG)
    MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
  • MAPK signaling pathway, conserved biosystem (from KEGG)
    MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
  • Melanoma, organism-specific biosystem (from KEGG)
    Melanoma, organism-specific biosystemMelanoma is a form of skin cancer that has a poor prognosis and which is on the rise in Western populations. Melanoma arises from the malignant transformation of pigment-producing cells, melanocytes...
  • Melanoma, conserved biosystem (from KEGG)
    Melanoma, conserved biosystemMelanoma is a form of skin cancer that has a poor prognosis and which is on the rise in Western populations. Melanoma arises from the malignant transformation of pigment-producing cells, melanocytes...
  • Muscle contraction, organism-specific biosystem (from REACTOME)
    Muscle contraction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • PI3K-Akt signaling pathway, organism-specific biosystem (from KEGG)
    PI3K-Akt signaling pathway, organism-specific biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
  • PI3K-Akt signaling pathway, conserved biosystem (from KEGG)
    PI3K-Akt signaling pathway, conserved biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
  • Pathways in cancer, organism-specific biosystem (from KEGG)
    Pathways in cancer, organism-specific biosystem
    Pathways in cancer
  • Phase 0 - rapid depolarisation, organism-specific biosystem (from REACTOME)
    Phase 0 - rapid depolarisation, organism-specific biosystemcomputationally inferred pathway (not manually curated)
  • Rap1 signaling pathway, organism-specific biosystem (from KEGG)
    Rap1 signaling pathway, organism-specific biosystemRap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an ac...
  • Rap1 signaling pathway, conserved biosystem (from KEGG)
    Rap1 signaling pathway, conserved biosystemRap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an ac...
  • Ras signaling pathway, organism-specific biosystem (from KEGG)
    Ras signaling pathway, organism-specific biosystemThe Ras proteins are GTPases that function as molecular switches for signaling pathways regulating cell proliferation, survival, growth, migration, differentiation or cytoskeletal dynamism. Ras prote...
  • Regulation of Actin Cytoskeleton, organism-specific biosystem (from WikiPathways)
    Regulation of Actin Cytoskeleton, organism-specific biosystem
    Regulation of Actin Cytoskeleton
  • Regulation of actin cytoskeleton, organism-specific biosystem (from KEGG)
    Regulation of actin cytoskeleton, organism-specific biosystem
    Regulation of actin cytoskeleton
  • Regulation of actin cytoskeleton, conserved biosystem (from KEGG)
    Regulation of actin cytoskeleton, conserved biosystem
    Regulation of actin cytoskeleton

General gene information

Markers

Homology

Clone Names

  • MGC129318, MGC129319

Gene Ontology Provided by MGI

Function Evidence Code Pubs
NOT fibroblast growth factor receptor binding ISO
Inferred from Sequence Orthology
more info
 
growth factor activity ISO
Inferred from Sequence Orthology
more info
 
heparin binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
JNK cascade ISO
Inferred from Sequence Orthology
more info
 
adult locomotory behavior IGI
Inferred from Genetic Interaction
more info
PubMed 
chemical synaptic transmission IGI
Inferred from Genetic Interaction
more info
PubMed 
NOT fibroblast growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
nervous system development IEA
Inferred from Electronic Annotation
more info
 
neuromuscular process IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of high voltage-gated calcium channel activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of high voltage-gated calcium channel activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of sodium ion transport IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of postsynaptic membrane potential ISO
Inferred from Sequence Orthology
more info
 
regulation of synaptic plasticity ISO
Inferred from Sequence Orthology
more info
 
regulation of synaptic vesicle recycling ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
fibroblast growth factor 14
Names
FGF-14
fibroblast growth factor 14, isoform b
fibroblast growth factor homologous factor 4

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010201.4NP_034331.2  fibroblast growth factor 14 isoform a

    See identical proteins and their annotated locations for NP_034331.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR and coding sequence compared to variant 2. The resulting isoform (a) has a shorter and distinct N-terminus compared to isoform b.
    Source sequence(s)
    AC161001, AK030616
    Consensus CDS
    CCDS27356.1
    UniProtKB/Swiss-Prot
    P70379
    UniProtKB/TrEMBL
    A0A0R4J063
    Related
    ENSMUSP00000026631.5, OTTMUSP00000023899, ENSMUST00000026631.5, OTTMUST00000050937
    Conserved Domains (1) summary
    smart00442
    Location:69199
    FGF; Acidic and basic fibroblast growth factor family
  2. NM_207667.3NP_997550.1  fibroblast growth factor 14 isoform b

    See identical proteins and their annotated locations for NP_997550.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents the longer transcript and encodes the longer isoform (b).
    Source sequence(s)
    AC161001, AK079100
    Consensus CDS
    CCDS27355.1
    UniProtKB/TrEMBL
    O89096
    Related
    ENSMUSP00000093185.3, OTTMUSP00000023900, ENSMUST00000095529.9, OTTMUST00000050938
    Conserved Domains (1) summary
    smart00442
    Location:74204
    FGF; Acidic and basic fibroblast growth factor family

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000080.6 Reference GRCm38.p4 C57BL/6J

    Range
    123973845..124677667 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017315845.1XP_017171334.1  fibroblast growth factor 14 isoform X1

  2. XM_011244952.2XP_011243254.1  fibroblast growth factor 14 isoform X2

    See identical proteins and their annotated locations for XP_011243254.1

    UniProtKB/Swiss-Prot
    P70379
    Conserved Domains (1) summary
    smart00442
    Location:1115
    FGF; Acidic and basic fibroblast growth factor family
  3. XM_006518549.3XP_006518612.1  fibroblast growth factor 14 isoform X3

    Conserved Domains (1) summary
    cl00060
    Location:77155
    FGF; Acidic and basic fibroblast growth factor family; FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family plays essential roles in patterning and differentiation during vertebrate ...
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