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Lgr5 leucine rich repeat containing G protein coupled receptor 5 [ Mus musculus (house mouse) ]

Gene ID: 14160, updated on 31-Jan-2023

Summary

Official Symbol
Lgr5provided by MGI
Official Full Name
leucine rich repeat containing G protein coupled receptor 5provided by MGI
Primary source
MGI:MGI:1341817
See related
Ensembl:ENSMUSG00000020140 AllianceGenome:MGI:1341817
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
FEX; Gpr49
Summary
The protein encoded by this gene is a leucine-rich repeat-containing receptor (LGR) and member of the G protein-coupled, 7-transmembrane receptor (GPCR) superfamily. The encoded protein is a receptor for R-spondins and is involved in the canonical Wnt signaling pathway. This protein plays a role in the formation and maintenance of adult intestinal stem cells during postembryonic development. [provided by RefSeq, Sep 2015]
Expression
Broad expression in frontal lobe adult (RPKM 8.3), limb E14.5 (RPKM 3.7) and 18 other tissues See more
Orthologs
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Genomic context

See Lgr5 in Genome Data Viewer
Location:
10; 10 D2
Exon count:
18
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (115286219..115423685, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (115450314..115587780, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53633 Neighboring gene THAP domain containing, apoptosis associated protein 2 Neighboring gene zinc finger, C3H1-type containing Neighboring gene RIKEN cDNA A930009A15 gene Neighboring gene ribosomal protein S3A pseudogene Neighboring gene RIKEN cDNA 4930422I22 gene Neighboring gene tetraspanin 8

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables protein-hormone receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables transmembrane signaling receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables transmembrane signaling receptor activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in trans-Golgi network membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
leucine-rich repeat-containing G-protein coupled receptor 5
Names
G protein-coupled receptor 49
follicle expressed hormone
orphan G-protein coupled receptor FEX

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010195.2NP_034325.2  leucine-rich repeat-containing G-protein coupled receptor 5 precursor

    See identical proteins and their annotated locations for NP_034325.2

    Status: REVIEWED

    Source sequence(s)
    AK132387, BM935530
    Consensus CDS
    CCDS24180.1
    UniProtKB/Swiss-Prot
    Q3V1L2, Q9Z1P4
    Related
    ENSMUSP00000020350.9, ENSMUST00000020350.15
    Conserved Domains (6) summary
    smart00013
    Location:3370
    LRRNT; Leucine rich repeat N-terminal domain
    cd00116
    Location:88386
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00031
    Location:354375
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:6891
    LRR_RI; leucine-rich repeat [structural motif]
    pfam00001
    Location:575820
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    pfam13855
    Location:92150
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    115286219..115423685 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)