Format

Send to:

Choose Destination

Lgr5 leucine rich repeat containing G protein coupled receptor 5 [ Mus musculus (house mouse) ]

Gene ID: 14160, updated on 9-Jul-2019

Summary

Official Symbol
Lgr5provided by MGI
Official Full Name
leucine rich repeat containing G protein coupled receptor 5provided by MGI
Primary source
MGI:MGI:1341817
See related
Ensembl:ENSMUSG00000020140
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
FEX; Gpr49
Summary
The protein encoded by this gene is a leucine-rich repeat-containing receptor (LGR) and member of the G protein-coupled, 7-transmembrane receptor (GPCR) superfamily. The encoded protein is a receptor for R-spondins and is involved in the canonical Wnt signaling pathway. This protein plays a role in the formation and maintenance of adult intestinal stem cells during postembryonic development. [provided by RefSeq, Sep 2015]
Expression
Broad expression in frontal lobe adult (RPKM 8.3), limb E14.5 (RPKM 3.7) and 18 other tissues See more
Orthologs

Genomic context

See Lgr5 in Genome Data Viewer
Location:
10; 10 D2
Exon count:
18
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 10 NC_000076.6 (115450314..115587780, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (114887370..115024836, complement)

Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 46180 Neighboring gene THAP domain containing, apoptosis associated protein 2 Neighboring gene zinc finger, C3H1-type containing Neighboring gene RIKEN cDNA A930009A15 gene Neighboring gene ribosomal protein S3A pseudogene Neighboring gene RIKEN cDNA 4930422I22 gene Neighboring gene tetraspanin 8

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (6)  1 citation
  • Endonuclease-mediated (2) 

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
G protein-coupled peptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
protein-hormone receptor activity IEA
Inferred from Electronic Annotation
more info
 
transmembrane signaling receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
transmembrane signaling receptor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
activation of adenylate cyclase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
epithelial cell proliferation involved in renal tubule morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
hair follicle development IGI
Inferred from Genetic Interaction
more info
PubMed 
hormone-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
inner ear development IDA
Inferred from Direct Assay
more info
PubMed 
oocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
regulation of cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
trans-Golgi network membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
leucine-rich repeat-containing G-protein coupled receptor 5
Names
G protein-coupled receptor 49
follicle expressed hormone
orphan G-protein coupled receptor FEX

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010195.2NP_034325.2  leucine-rich repeat-containing G-protein coupled receptor 5 precursor

    See identical proteins and their annotated locations for NP_034325.2

    Status: REVIEWED

    Source sequence(s)
    AK132387, BM935530
    Consensus CDS
    CCDS24180.1
    UniProtKB/Swiss-Prot
    Q9Z1P4
    Related
    ENSMUSP00000020350.8, ENSMUST00000020350.14
    Conserved Domains (6) summary
    smart00013
    Location:3370
    LRRNT; Leucine rich repeat N-terminal domain
    cd00116
    Location:88386
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00031
    Location:354375
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:6891
    LRR_RI; leucine-rich repeat [structural motif]
    pfam00001
    Location:575820
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    pfam13855
    Location:92150
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000076.6 Reference GRCm38.p4 C57BL/6J

    Range
    115450314..115587780 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center