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Fes feline sarcoma oncogene [ Mus musculus (house mouse) ]

Gene ID: 14159, updated on 18-Sep-2024

Summary

Official Symbol
Fesprovided by MGI
Official Full Name
feline sarcoma oncogeneprovided by MGI
Primary source
MGI:MGI:95514
See related
Ensembl:ENSMUSG00000053158 AllianceGenome:MGI:95514
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
FPS; c-fes
Summary
Enables microtubule binding activity and protein kinase activity. Acts upstream of or within centrosome cycle and microtubule bundle formation. Located in microtubule cytoskeleton. Is expressed in central nervous system and retina. Orthologous to human FES (FES proto-oncogene, tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in spleen adult (RPKM 20.4), lung adult (RPKM 18.5) and 26 other tissues See more
Orthologs
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Genomic context

See Fes in Genome Data Viewer
Location:
7 D2; 7 45.65 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (80027506..80037702, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (80377758..80387954, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene HD domain containing 3 Neighboring gene high mobility group box 2 pseudogene Neighboring gene mannosidase 2, alpha 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:87520664-87520847 Neighboring gene furin, paired basic amino acid cleaving enzyme Neighboring gene predicted gene 44851 Neighboring gene serine hydroxymethyltransferase 2 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (6)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables immunoglobulin receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables immunoglobulin receptor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables microtubule binding IDA
Inferred from Direct Assay
more info
PubMed 
enables non-membrane spanning protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables non-membrane spanning protein tyrosine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables phosphatidylinositol binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphatidylinositol binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables protein tyrosine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein tyrosine kinase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
involved_in cardiac muscle cell proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cellular response to vitamin D IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to vitamin D ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within centrosome cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within microtubule bundle formation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in myoblast proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in peptidyl-tyrosine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in peptidyl-tyrosine phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of microtubule polymerization ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of microtubule polymerization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of monocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of monocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of myeloid cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of myeloid cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neuron projection development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein autophosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell adhesion ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of cell motility ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell motility ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell population proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of cell shape ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell shape ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of mast cell degranulation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of mast cell degranulation ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytoplasmic side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic side of plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
colocalizes_with cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with cytoplasmic vesicle ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in focal adhesion ISO
Inferred from Sequence Orthology
more info
 
located_in focal adhesion ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
PubMed 
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in microtubule cytoskeleton ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
tyrosine-protein kinase Fes/Fps
Names
proto-oncogene c-Fes
proto-oncogene tyrosine-protein kinase Fes/Fps
tyrosine kinase Fps/Fes
NP_034324.2
XP_006540667.1
XP_036008562.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010194.2NP_034324.2  tyrosine-protein kinase Fes/Fps

    See identical proteins and their annotated locations for NP_034324.2

    Status: VALIDATED

    Source sequence(s)
    AC136740, AK143639, BC038130
    Consensus CDS
    CCDS39999.1
    UniProtKB/Swiss-Prot
    P16879, Q3TD20, Q62122, Q8CG02
    UniProtKB/TrEMBL
    A0A0U1RPM2
    Related
    ENSMUSP00000079733.7, ENSMUST00000080932.8
    Conserved Domains (3) summary
    cd07685
    Location:7239
    F-BAR_Fes; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Fes (feline sarcoma) tyrosine kinase
    cd10361
    Location:453537
    SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins
    cl21453
    Location:564814
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    80027506..80037702 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006540604.5XP_006540667.1  tyrosine-protein kinase Fes/Fps isoform X1

    See identical proteins and their annotated locations for XP_006540667.1

    UniProtKB/Swiss-Prot
    P16879, Q3TD20, Q62122, Q8CG02
    UniProtKB/TrEMBL
    A0A0U1RPM2
    Related
    ENSMUSP00000146041.2, ENSMUST00000206728.2
    Conserved Domains (3) summary
    cd07685
    Location:7239
    F-BAR_Fes; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Fes (feline sarcoma) tyrosine kinase
    cd10361
    Location:453537
    SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins
    cl21453
    Location:564814
    PKc_like; Protein Kinases, catalytic domain
  2. XM_036152669.1XP_036008562.1  tyrosine-protein kinase Fes/Fps isoform X2

    Conserved Domains (2) summary
    cd10361
    Location:453537
    SH2_Fps_family; Src homology 2 (SH2) domain found in feline sarcoma, Fujinami poultry sarcoma, and fes-related (Fes/Fps/Fer) proteins
    cl12013
    Location:7239
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

RNA

  1. XR_003946388.1 RNA Sequence

    Related
    ENSMUST00000206744.2