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Fem1b fem 1 homolog b [ Mus musculus (house mouse) ]

Gene ID: 14155, updated on 24-Jan-2023

Summary

Official Symbol
Fem1bprovided by MGI
Official Full Name
fem 1 homolog bprovided by MGI
Primary source
MGI:MGI:1335087
See related
Ensembl:ENSMUSG00000032244 AllianceGenome:MGI:1335087
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA0396
Summary
Predicted to enable death receptor binding activity and ubiquitin ligase-substrate adaptor activity. Acts upstream of or within branching involved in prostate gland morphogenesis; epithelial cell maturation involved in prostate gland development; and protein ubiquitination. Located in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; genitourinary system; liver; retina; and spleen. Used to study type 2 diabetes mellitus. Orthologous to human FEM1B (fem-1 homolog B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis adult (RPKM 35.7), placenta adult (RPKM 32.6) and 24 other tissues See more
Orthologs
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Genomic context

See Fem1b in Genome Data Viewer
Location:
9 B; 9 33.87 cM
Exon count:
2
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (62699106..62718930, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (62791824..62811648, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene integrin alpha 11 Neighboring gene dCTP pyrophosphatase 1 pseudogene Neighboring gene ribsomal protein S2 pseudogene Neighboring gene ceroid-lipofuscinosis, neuronal 6 Neighboring gene calmodulin-like 4

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables death receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin ligase-substrate adaptor activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of Cul2-RING ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
protein fem-1 homolog B
Names
F1A-alpha
FEM1-beta
fem-1-like death receptor-binding protein alpha
fem-1-like in apoptotic pathway protein alpha
feminization 1 homolog b
mt-Fem

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_010193.4NP_034323.1  protein fem-1 homolog B

    Status: VALIDATED

    Source sequence(s)
    AI854655, AK122272, AK149329, AK160393, CJ047815
    Consensus CDS
    CCDS23266.1
    UniProtKB/Swiss-Prot
    Q9QZL3, Q9Z2G0
    UniProtKB/TrEMBL
    A0A6P5QD70, A0A8C6G819
    Related
    ENSMUSP00000034775.9, ENSMUST00000034775.10
    Conserved Domains (4) summary
    cd00204
    Location:87207
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:87118
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:11117
    Ank_2; Ankyrin repeats (3 copies)
    cl26073
    Location:101366
    Ank_2; Ankyrin repeats (3 copies)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    62699106..62718930 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)