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Fdft1 farnesyl diphosphate farnesyl transferase 1 [ Mus musculus (house mouse) ]

Gene ID: 14137, updated on 23-May-2018

Summary

Official Symbol
Fdft1provided by MGI
Official Full Name
farnesyl diphosphate farnesyl transferase 1provided by MGI
Primary source
MGI:MGI:102706
See related
Ensembl:ENSMUSG00000021273
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SS; SQS
Expression
Ubiquitous expression in testis adult (RPKM 35.8), CNS E18 (RPKM 14.9) and 28 other tissues See more
Orthologs

Genomic context

See Fdft1 in Genome Data Viewer
Location:
14 D1; 14 33.24 cM
Exon count:
11
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 14 NC_000080.6 (63145150..63181687, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (63763987..63796630, complement)

Chromosome 14 - NC_000080.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 35908 Neighboring gene predicted gene, 36025 Neighboring gene tubulin, alpha 3B pseudogene Neighboring gene cathepsin B Neighboring gene nei like 2 (E. coli) Neighboring gene GATA binding protein 4

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
catalytic activity IEA
Inferred from Electronic Annotation
more info
 
farnesyl-diphosphate farnesyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
farnesyl-diphosphate farnesyltransferase activity ISO
Inferred from Sequence Orthology
more info
 
squalene synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
transferase activity, transferring alkyl or aryl (other than methyl) groups IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
cholesterol biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cholesterol biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
cholesterol metabolic process IEA
Inferred from Electronic Annotation
more info
 
ergosterol biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
farnesyl diphosphate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
farnesyl diphosphate metabolic process ISO
Inferred from Sequence Orthology
more info
 
isoprenoid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
lipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
metabolic process IEA
Inferred from Electronic Annotation
more info
 
steroid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
steroid metabolic process IEA
Inferred from Electronic Annotation
more info
 
sterol biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
squalene synthase
Names
FPP:FPP farnesyltransferase
farnesyl-diphosphate farnesyltransferase
NP_034321.2
XP_006518610.1
XP_017171333.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360211.1NP_001347140.1  squalene synthase

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents transcription from a major CAGE transcription cluster, and represents the shorter transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK169317, BC054722, BY293142
    Conserved Domains (1) summary
    cl00210
    Location:38370
    Isoprenoid_Biosyn_C1; Isoprenoid Biosynthesis enzymes, Class 1
  2. NM_010191.3NP_034321.2  squalene synthase

    See identical proteins and their annotated locations for NP_034321.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK136159, BC054722
    Consensus CDS
    CCDS27198.1
    UniProtKB/Swiss-Prot
    P53798
    Related
    ENSMUSP00000153671.1, ENSMUST00000224625.1
    Conserved Domains (1) summary
    cl00210
    Location:38370
    Isoprenoid_Biosyn_C1; Isoprenoid Biosynthesis enzymes, Class 1

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000080.6 Reference GRCm38.p4 C57BL/6J

    Range
    63145150..63181687 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017315844.1XP_017171333.1  squalene synthase isoform X1

    UniProtKB/Swiss-Prot
    P53798
    Conserved Domains (1) summary
    cl00210
    Location:38370
    Isoprenoid_Biosyn_C1; Isoprenoid Biosynthesis enzymes, Class 1
  2. XM_006518547.3XP_006518610.1  squalene synthase isoform X2

    Conserved Domains (1) summary
    cl00210
    Location:1221
    Isoprenoid_Biosyn_C1; Isoprenoid Biosynthesis enzymes, Class 1
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