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Fcer2a Fc receptor, IgE, low affinity II, alpha polypeptide [ Mus musculus (house mouse) ]

Gene ID: 14128, updated on 18-Apr-2024

Summary

Official Symbol
Fcer2aprovided by MGI
Official Full Name
Fc receptor, IgE, low affinity II, alpha polypeptideprovided by MGI
Primary source
MGI:MGI:95497
See related
Ensembl:ENSMUSG00000005540 AllianceGenome:MGI:95497
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CD23; Fce2; Fcer2; Ly-42
Summary
Predicted to enable carbohydrate binding activity. Acts upstream of or within positive regulation of humoral immune response mediated by circulating immunoglobulin. Located in external side of plasma membrane. Orthologous to human FCER2 (Fc fragment of IgE receptor II). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in spleen adult (RPKM 10.2), mammary gland adult (RPKM 7.3) and 24 other tissues See more
Orthologs
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Genomic context

Location:
8 A1.1; 8 1.92 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (3730280..3744174, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (3680280..3694174, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39121 Neighboring gene predicted gene 45231 Neighboring gene trafficking protein particle complex 5 Neighboring gene C-type lectin domain family 4, member g Neighboring gene predicted gene 16553 Neighboring gene STARR-positive B cell enhancer mm9_chr8:3718569-3718869 Neighboring gene CD209a antigen

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Spontaneous (1)  1 citation
  • Chemically induced (ENU) (1) 
  • Endonuclease-mediated (3) 
  • Targeted (3)  1 citation

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables IgE binding ISO
Inferred from Sequence Orthology
more info
 
enables carbohydrate binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables low-affinity IgE receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
low affinity immunoglobulin epsilon Fc receptor
Names
FC epsilon RII
fc-epsilon-RII
low-affinity IgE receptor
lymphocyte IgE receptor

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001253737.1NP_001240666.1  low affinity immunoglobulin epsilon Fc receptor isoform B

    See identical proteins and their annotated locations for NP_001240666.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has a different 5' end with an alternate start codon, compared to variant 1. The resulting protein (isoform B) has a shorter and distinct N-terminus when it is compared to isoform A. Although variants 2 and 3 encode a protein of the same length (330 aa), the sequence of the two proteins (isoform B and isoform C) are different.
    Source sequence(s)
    AC087183, M34163
    Consensus CDS
    CCDS85494.1
    UniProtKB/TrEMBL
    A0A140LI63
    Related
    ENSMUSP00000146568.2, ENSMUST00000208492.2
    Conserved Domains (2) summary
    cd03590
    Location:185305
    CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
    cl23720
    Location:72169
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
  2. NM_001253739.1NP_001240668.1  low affinity immunoglobulin epsilon Fc receptor isoform C

    See identical proteins and their annotated locations for NP_001240668.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has a different 5' end with an alternate start codon, compared to variant 1. The resulting protein (isoform C) has a shorter and distinct N-terminus when it is compared to isoform A. Although variants 2 and 3 encode a protein of the same length (330 aa), the sequence of the two proteins (isoform B and isoform C) are different.
    Source sequence(s)
    AC087183, M34163
    Consensus CDS
    CCDS85491.1
    UniProtKB/TrEMBL
    A0A140LI63
    Related
    ENSMUSP00000146647.2, ENSMUST00000208145.2
    Conserved Domains (2) summary
    cd03590
    Location:185305
    CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
    cl23720
    Location:72169
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
  3. NM_001253743.1NP_001240672.1  low affinity immunoglobulin epsilon Fc receptor isoform A

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses a different splice site in the 5' coding region, compared to variant 1. The resulting protein (isoform D) is shorter when it is compared to isoform A.
    Source sequence(s)
    AC087183, M34163
    UniProtKB/TrEMBL
    A0A140LI63
    Related
    ENSMUSP00000146689.2, ENSMUST00000207635.2
    Conserved Domains (2) summary
    cd03590
    Location:159279
    CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
    cl23720
    Location:46143
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
  4. NM_001253745.1NP_001240674.1  low affinity immunoglobulin epsilon Fc receptor isoform E

    See identical proteins and their annotated locations for NP_001240674.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) has a different 5' end with an alternate start codon and lacks an alternate exon in the coding region, compared to variant 1. The resulting protein (isoform E) has a shorter and distinct N-terminus when it is compared to isoform A. Although variants 5 and 6 encode a protein of the same length (309 aa), the sequence of the two proteins (isoform E and isoform F) are different. Isoform E has also been called Fc epsilon receptor II subtype b variant b delta 5.
    Source sequence(s)
    AC087183, M34163
    Consensus CDS
    CCDS85492.1
    UniProtKB/TrEMBL
    A0A140LI63, Q8VH33
    Related
    ENSMUSP00000146380.2, ENSMUST00000208603.2
    Conserved Domains (2) summary
    cd03590
    Location:164284
    CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
    cl23720
    Location:72148
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
  5. NM_001253746.1NP_001240675.1  low affinity immunoglobulin epsilon Fc receptor isoform F

    See identical proteins and their annotated locations for NP_001240675.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) has a different 5' end with an alternate start codon and lacks an alternate exon in the coding region, compared to variant 1. The resulting protein (isoform F) has a shorter and distinct N-terminus when it is compared to isoform A. Although variants 5 and 6 encode a protein of the same length (309 aa), the sequence of the two proteins (isoform E and isoform F) are different. Isoform F has also been called Fc epsilon receptor II subtype b variant b delta 6.
    Source sequence(s)
    AC087183, M34163
    Consensus CDS
    CCDS85493.1
    UniProtKB/TrEMBL
    A0A140LI63, Q8VH32
    Related
    ENSMUSP00000146822.2, ENSMUST00000208438.2
    Conserved Domains (2) summary
    cd03590
    Location:164284
    CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
    cl23765
    Location:70127
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
  6. NM_001253747.1NP_001240676.1  low affinity immunoglobulin epsilon Fc receptor isoform G

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) lacks an alternate exon in the 5' coding region, compared to variant 1. The resulting protein (isoform G) is shorter when it is compared to isoform A.
    Source sequence(s)
    AC087183, M34163
    UniProtKB/TrEMBL
    A0A140LJ27
    Related
    ENSMUSP00000147052.2, ENSMUST00000207463.2
    Conserved Domains (2) summary
    cd03590
    Location:146266
    CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
    cl23720
    Location:33130
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
  7. NM_013517.4NP_038545.1  low affinity immunoglobulin epsilon Fc receptor isoform A

    See identical proteins and their annotated locations for NP_038545.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and it encodes the longest protein (isoform A).
    Source sequence(s)
    AC087183, M34163
    Consensus CDS
    CCDS22071.1
    UniProtKB/Swiss-Prot
    P20693, Q61556, Q61557
    UniProtKB/TrEMBL
    A0A140LI63
    Related
    ENSMUSP00000005678.5, ENSMUST00000005678.6
    Conserved Domains (2) summary
    cd03590
    Location:186306
    CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
    cl23720
    Location:73170
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    3730280..3744174 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006508697.5XP_006508760.1  low affinity immunoglobulin epsilon Fc receptor isoform X1

    UniProtKB/TrEMBL
    A0A140LI63
    Conserved Domains (2) summary
    cd03590
    Location:190310
    CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)
    TIGR04211
    Location:77175
    SH3_and_anchor; SH3 domain protein