U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Fbln1 fibulin 1 [ Mus musculus (house mouse) ]

Gene ID: 14114, updated on 5-Jan-2023

Summary

Official Symbol
Fbln1provided by MGI
Official Full Name
fibulin 1provided by MGI
Primary source
MGI:MGI:95487
See related
Ensembl:ENSMUSG00000006369 AllianceGenome:MGI:95487
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables peptidase activator activity. Acts upstream of or within extracellular matrix organization. Located in basement membrane. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; embryo mesenchyme; and heart. Orthologous to human FBLN1 (fibulin 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in bladder adult (RPKM 164.9), duodenum adult (RPKM 105.0) and 16 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Fbln1 in Genome Data Viewer
Location:
15; 15 E2
Exon count:
18
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (85090150..85170495)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (85205949..85286294)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene RIB43A domain with coiled-coils 2 Neighboring gene predicted gene, 19277 Neighboring gene predicted gene, 34337 Neighboring gene ataxin 10 Neighboring gene predicted gene, 23517

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables extracellular matrix structural constituent ISO
Inferred from Sequence Orthology
more info
 
enables extracellular matrix structural constituent RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
enables fibrinogen binding ISO
Inferred from Sequence Orthology
more info
 
enables fibronectin binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables integrin binding ISO
Inferred from Sequence Orthology
more info
 
enables peptidase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in blood coagulation, fibrin clot formation ISO
Inferred from Sequence Orthology
more info
 
involved_in extracellular matrix organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within extracellular matrix organization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell motility ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of stem cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of substrate adhesion-dependent cell spreading ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transformation of host cell by virus ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transforming growth factor beta production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of fibroblast proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of substrate-dependent cell migration, cell attachment to substrate ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
fibulin-1
Names
BM-90
BM-90/fibulin extracellular matrix glyroprotein
FIBL-1
basement-membrane protein 90

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347088.1NP_001334017.1  fibulin-1 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AI845853, AK035388, AL583891, BQ572803
    Consensus CDS
    CCDS84186.1
    UniProtKB/Swiss-Prot
    Q08879
    UniProtKB/TrEMBL
    A0A8C6HKP3
    Related
    ENSMUSP00000105058.4, ENSMUST00000109432.4
  2. NM_010180.2NP_034310.2  fibulin-1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_034310.2

    Status: VALIDATED

    Source sequence(s)
    AA017744, AK083573, AK085989, AK086451, AK159646
    Consensus CDS
    CCDS27719.1
    UniProtKB/Swiss-Prot
    Q08879, Q922K8
    UniProtKB/TrEMBL
    A0A8C6HHM9, B2CQD6, Q3TWK8
    Related
    ENSMUSP00000054583.8, ENSMUST00000057410.14
    Conserved Domains (5) summary
    smart00179
    Location:401442
    EGF_CA; Calcium-binding EGF-like domain
    cd00017
    Location:3085
    ANATO; Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments generated enzymatically in serum during activation of complement molecules C3, C4, and C5. They induce smooth muscle contraction. These fragments are homologous to ...
    pfam07645
    Location:218261
    EGF_CA; Calcium-binding EGF domain
    pfam12662
    Location:506530
    cEGF; Complement Clr-like EGF-like
    cl00057
    Location:481524
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    85090150..85170495
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)