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Srsf10 serine and arginine-rich splicing factor 10 [ Mus musculus (house mouse) ]

Gene ID: 14105, updated on 8-Dec-2022

Summary

Official Symbol
Srsf10provided by MGI
Official Full Name
serine and arginine-rich splicing factor 10provided by MGI
Primary source
MGI:MGI:1333805
See related
Ensembl:ENSMUSG00000028676 AllianceGenome:MGI:1333805
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Nssr; TASR; NSSR1; NSSR2; TASR1; TASR2; FUSIP2; Fusip1; SRrp40; Sfrs13a; Srsf13a
Summary
Predicted to enable RNA binding activity. Involved in RNA splicing, via transesterification reactions; cytosolic transport; and negative regulation of mRNA splicing, via spliceosome. Located in nucleoplasm. Is expressed in several structures, including brain; branchial arch; foregut-midgut junction; heart ventricle; and sensory organ. Orthologous to human SRSF10 (serine and arginine rich splicing factor 10). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 24.5), limb E14.5 (RPKM 19.6) and 28 other tissues See more
Orthologs
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Genomic context

See Srsf10 in Genome Data Viewer
Location:
4; 4 D3
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (135582454..135597219)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (135855752..135869908)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene S-phase kinase-associated protein 1A pseudogene Neighboring gene myomesin family, member 3 Neighboring gene proline-rich nuclear receptor coactivator 2 Neighboring gene cannabinoid receptor 2 (macrophage)

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA binding NAS
Non-traceable Author Statement
more info
PubMed 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables unfolded protein binding NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in axon terminus ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
is_active_in nuclear speck IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
serine/arginine-rich splicing factor 10
Names
FUS-interacting serine-arginine-rich protein 1
Fus-associated protein with serine-arginine repeats
TLS-associated SR protein
TLS-associated protein with SR repeats
TLS-associated protein with Ser-Arg repeats
TLS-associated serine-arginine protein
neural-salient serine/arginine-rich protein
neural-specific SR protein
serine/arginine-rich splicing factor 13A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080387.2NP_001073856.1  serine/arginine-rich splicing factor 10 isoform 2

    See identical proteins and their annotated locations for NP_001073856.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) encodes the longest isoform (2).
    Source sequence(s)
    AK168558, BC043060, BY244789, BY717856
    Consensus CDS
    CCDS38922.1
    UniProtKB/Swiss-Prot
    Q9R0T9, Q9R0U0
    UniProtKB/TrEMBL
    A0A6P5PJ25, A0A8C6MQR0
    Related
    ENSMUSP00000101479.4, ENSMUST00000105853.10
    Conserved Domains (1) summary
    cl17169
    Location:599
    RRM_SF; RNA recognition motif (RRM) superfamily
  2. NM_001284195.1NP_001271124.1  serine/arginine-rich splicing factor 10 isoform 3

    See identical proteins and their annotated locations for NP_001271124.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 3' coding region, compared to variant 2. It encodes isoform 3, which is shorter than isoform 2.
    Source sequence(s)
    AK168524, BC043060, BY244789, BY717856, CF914989, CN528501
    Consensus CDS
    CCDS71493.1
    UniProtKB/Swiss-Prot
    Q9R0U0
    UniProtKB/TrEMBL
    A0A6P5PLU9
    Related
    ENSMUSP00000095455.3, ENSMUST00000097844.9
    Conserved Domains (1) summary
    cl17169
    Location:599
    RRM_SF; RNA recognition motif (RRM) superfamily
  3. NM_001284196.1NP_001271125.1  serine/arginine-rich splicing factor 10 isoform 4

    See identical proteins and their annotated locations for NP_001271125.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate in-frame splice site in the 3' coding region and contains an alternate 3' terminal exon, compared to variant 2. It encodes isoform 4, which is shorter and has a distinct C-terminus, compared to isoform 2.
    Source sequence(s)
    AF042383, AK030968, AK168571, AK169071, BY244789, BY717856
    Consensus CDS
    CCDS71494.1
    UniProtKB/Swiss-Prot
    Q9R0U0
    UniProtKB/TrEMBL
    A0A6P5PQA1, Q3TFP0, Q3UA07
    Related
    ENSMUSP00000099603.3, ENSMUST00000102544.9
    Conserved Domains (1) summary
    cl17169
    Location:599
    RRM_SF; RNA recognition motif (RRM) superfamily
  4. NM_010178.3NP_034308.1  serine/arginine-rich splicing factor 10 isoform 1

    See identical proteins and their annotated locations for NP_034308.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) contains an alternate 3' terminal exon compared to variant 2. It encodes isoform 1, which is shorter and has a distinct C-terminus, compared to isoform 2.
    Source sequence(s)
    AF042383, AK030968, AK168558, AK168571, BY244789, BY717856
    Consensus CDS
    CCDS18791.1
    UniProtKB/Swiss-Prot
    Q9R0U0
    UniProtKB/TrEMBL
    A0A6P5PEA0, A0A8C6MQQ6, Q3UA07
    Related
    ENSMUSP00000114564.2, ENSMUST00000126641.2
    Conserved Domains (1) summary
    cd12559
    Location:599
    RRM_SRSF10; RNA recognition motif (RRM) found in serine/arginine-rich splicing factor 10 (SRSF10) and similar proteins

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    135582454..135597219
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011250188.3XP_011248490.1  serine/arginine-rich splicing factor 10 isoform X3

    See identical proteins and their annotated locations for XP_011248490.1

    UniProtKB/TrEMBL
    A0A6P5PJ30
    Conserved Domains (1) summary
    cl17169
    Location:599
    RRM_SF; RNA recognition motif (RRM) superfamily
  2. XM_036163676.1XP_036019569.1  serine/arginine-rich splicing factor 10 isoform X1

    Conserved Domains (1) summary
    cd12559
    Location:599
    RRM_SRSF10; RNA recognition motif (RRM) found in serine/arginine-rich splicing factor 10 (SRSF10) and similar proteins
  3. XM_036163677.1XP_036019570.1  serine/arginine-rich splicing factor 10 isoform X2

    Conserved Domains (1) summary
    cl17169
    Location:599
    RRM_SF; RNA recognition motif (RRM) superfamily