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Fasl Fas ligand (TNF superfamily, member 6) [ Mus musculus (house mouse) ]

Gene ID: 14103, updated on 23-Nov-2021

Summary

Official Symbol
Faslprovided by MGI
Official Full Name
Fas ligand (TNF superfamily, member 6)provided by MGI
Primary source
MGI:MGI:99255
See related
Ensembl:ENSMUSG00000000817
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
gld; CD178; CD95L; Fas-L; Faslg; CD95-L; Tnfsf6; Tnlg1a; APT1LG1
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See Fasl in Genome Data Viewer
Location:
1 H2.1; 1 69.95 cM
Exon count:
4
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (161608260..161616064, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (161780691..161788495, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (163710820..163718626, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene glutamic pyruvic transaminase, soluble pseudogene Neighboring gene predicted gene, 31869 Neighboring gene SUN domain containing ossification factor Neighboring gene cyclin-dependent kinase 7 pseudogene Neighboring gene predicted gene, 31925

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cytokine activity IEA
Inferred from Electronic Annotation
more info
 
enables death receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables tumor necrosis factor receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in T cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within activation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular chloride ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in endosomal lumen acidification ISO
Inferred from Sequence Orthology
more info
 
involved_in extrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in extrinsic apoptotic signaling pathway via death domain receptors IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within extrinsic apoptotic signaling pathway via death domain receptors IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within extrinsic apoptotic signaling pathway via death domain receptors ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in extrinsic apoptotic signaling pathway via death domain receptors ISO
Inferred from Sequence Orthology
more info
 
involved_in immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in inflammatory cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in necroptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in necroptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of I-kappaB kinase/NF-kappaB signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of endothelial cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of epidermal growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of phosphatidylserine exposure on apoptotic cell surface ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within release of sequestered calcium ion into cytosol by endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within retinal cell programmed cell death IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in caveola ISO
Inferred from Sequence Orthology
more info
 
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular exosome ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in lysosome IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
tumor necrosis factor ligand superfamily member 6
Names
CD95 ligand
Fas antigen ligand
generalized lymphoproliferative disease
tumor necrosis factor ligand 1a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001205243.1NP_001192172.1  tumor necrosis factor ligand superfamily member 6 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the coding region, which results in a frameshift and an early stop codon, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC164414, AF288572
    UniProtKB/TrEMBL
    Q99PH8
  2. NM_010177.4NP_034307.1  tumor necrosis factor ligand superfamily member 6 isoform 1

    See identical proteins and their annotated locations for NP_034307.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK040139
    Consensus CDS
    CCDS15418.1
    UniProtKB/Swiss-Prot
    P41047
    UniProtKB/TrEMBL
    Q544E9
    Related
    ENSMUSP00000000834.3, ENSMUST00000000834.4
    Conserved Domains (1) summary
    cd00184
    Location:144277
    TNF; Tumor Necrosis Factor; TNF superfamily members include the cytokines: TNF (TNF-alpha), LT (lymphotoxin-alpha, TNF-beta), CD40 ligand, Apo2L (TRAIL), Fas ligand, and osteoprotegerin (OPG) ligand. These proteins generally have an intracellular N-terminal ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    161608260..161616064 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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