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ADPRH ADP-ribosylarginine hydrolase [ Homo sapiens (human) ]

Gene ID: 141, updated on 7-Jun-2020

Summary

Official Symbol
ADPRHprovided by HGNC
Official Full Name
ADP-ribosylarginine hydrolaseprovided by HGNC
Primary source
HGNC:HGNC:269
See related
Ensembl:ENSG00000144843 MIM:603081
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARH1; hARH1
Summary
The enzyme encoded by this gene catalyzes removal of mono-ADP-ribose from arginine residues of proteins in the ADP-ribosylation cycle. Unlike the rat and mouse enzymes that require DTT for maximal activity, the human enzyme is DTT-independent. Alternatively spliced transcript variants that encode different protein isoforms have been described. [provided by RefSeq, May 2014]
Expression
Ubiquitous expression in lung (RPKM 7.2), spleen (RPKM 6.0) and 25 other tissues See more
Orthologs

Genomic context

See ADPRH in Genome Data Viewer
Location:
3q13.33
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (119579492..119589945)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (119298280..119308792)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene CD80 molecule Neighboring gene Sharpr-MPRA regulatory region 12076 Neighboring gene uncharacterized LOC107986118 Neighboring gene uncharacterized LOC105374062 Neighboring gene phospholipase A1 member A Neighboring gene ribosomal protein L10 pseudogene 7

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ADP-ribosylarginine hydrolase activity IDA
Inferred from Direct Assay
more info
PubMed 
ADP-ribosylarginine hydrolase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Rab GTPase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
magnesium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
potassium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
activation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular protein modification process IMP
Inferred from Mutant Phenotype
more info
PubMed 
intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein de-ADP-ribosylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of autophagosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
autophagosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IEA
Inferred from Electronic Annotation
more info
 
extracellular space IEA
Inferred from Electronic Annotation
more info
 
recycling endosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
ADP-ribosylarginine hydrolase
Names
ADP-ribose-L-arginine cleaving enzyme
[Protein ADP-ribosylarginine] hydrolase
NP_001116.1
NP_001278878.1
NP_001278879.1
NP_001358021.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001125.4NP_001116.1  ADP-ribosylarginine hydrolase isoform 1

    See identical proteins and their annotated locations for NP_001116.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer protein. Variants 1, 2 and 4 encode the same protein (isoform 1).
    Source sequence(s)
    AC073352, BC063883, BC074769
    Consensus CDS
    CCDS2990.1
    UniProtKB/Swiss-Prot
    P54922
    Related
    ENSP00000349496.3, ENST00000357003.7
    Conserved Domains (1) summary
    pfam03747
    Location:6323
    ADP_ribosyl_GH; ADP-ribosylglycohydrolase
  2. NM_001291949.2NP_001278878.1  ADP-ribosylarginine hydrolase isoform 1

    See identical proteins and their annotated locations for NP_001278878.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 5' UTR compared to variant 1. Variants 1, 2 and 4 encode the same protein (isoform 1).
    Source sequence(s)
    AC073352, AK291787, BC063883, BC074769
    Consensus CDS
    CCDS2990.1
    UniProtKB/Swiss-Prot
    P54922
    UniProtKB/TrEMBL
    A8K6X2
    Related
    ENSP00000417528.1, ENST00000478927.5
    Conserved Domains (1) summary
    pfam03747
    Location:6323
    ADP_ribosyl_GH; ADP-ribosylglycohydrolase
  3. NM_001291950.2NP_001278879.1  ADP-ribosylarginine hydrolase isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks two exons, differs in the 5' UTR, and initiates translation at a downstream start codon compared to variant 1. The resulting protein (isoform 2) is shorter and has a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC073352, AK304560, BC063883
    UniProtKB/Swiss-Prot
    P54922
    UniProtKB/TrEMBL
    B4E341
    Conserved Domains (1) summary
    pfam03747
    Location:25216
    ADP_ribosyl_GH; ADP-ribosylglycohydrolase
  4. NM_001371092.1NP_001358021.1  ADP-ribosylarginine hydrolase isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs from variant 1 in the 5' UTR. Variants 1, 2 and 4 encode the same protein (isoform 1).
    Source sequence(s)
    AC073352

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    119579492..119589945
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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