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DCANP1 dendritic cell associated nuclear protein [ Homo sapiens (human) ]

Gene ID: 140947, updated on 23-Nov-2021

Summary

Official Symbol
DCANP1provided by HGNC
Official Full Name
dendritic cell associated nuclear proteinprovided by HGNC
Primary source
HGNC:HGNC:24459
See related
Ensembl:ENSG00000251380 MIM:609710
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DCNP1; C5orf20
Summary
This intronless gene is specifically expressed in dendritic cells (DCs), which are potent antigen-presenting cells involved in activating naive T cells to initiate antigen-specific immune response. The encoded protein is localized mainly in the perinucleus. One of the alleles (A/T) of this gene, that causes premature translation termination at aa 117, has been associated with an increased prevalence of major depression in humans. [provided by RefSeq, Jul 2008]
Orthologs
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Genomic context

See DCANP1 in Genome Data Viewer
Location:
5q31.1
Exon count:
1
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (135444214..135447348, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (134779904..134783038, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene PITX1 antisense RNA 1 Neighboring gene macroH2A.1 histone Neighboring gene VISTA enhancer hs1473 Neighboring gene TIFA inhibitor Neighboring gene neurogenin 1 Neighboring gene C-X-C motif chemokine ligand 14

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: TIFAB

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in auditory behavior IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cochlea development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cochlea morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in craniofacial suture morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in genitalia development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in genitalia morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in hard palate morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in inner ear development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in inner ear morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in learned vocalization behavior IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in mastication IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of relaxation of muscle IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of saliva secretion IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in neuromuscular process controlling balance IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in peristalsis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of muscle organ development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in thorax and anterior abdomen determination IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in trigeminal nerve development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in vestibulocochlear nerve formation IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear body IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
dendritic cell nuclear protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_130848.3NP_570900.1  dendritic cell nuclear protein 1

    See identical proteins and their annotated locations for NP_570900.1

    Status: REVIEWED

    Source sequence(s)
    AC022092
    Consensus CDS
    CCDS4186.1
    UniProtKB/Swiss-Prot
    Q8TF63
    Related
    ENSP00000421871.1, ENST00000503143.3

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    135444214..135447348 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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