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Higd1a HIG1 hypoxia inducible domain family, member 1A [ Rattus norvegicus (Norway rat) ]

Gene ID: 140937, updated on 18-Apr-2019

Summary

Official Symbol
Higd1aprovided by RGD
Official Full Name
HIG1 hypoxia inducible domain family, member 1Aprovided by RGD
Primary source
RGD:620215
See related
Ensembl:ENSRNOG00000019428
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Hig1
Summary
expressed in the nervous system; displays developmental regulation [RGD, Feb 2006]
Expression
Biased expression in Heart (RPKM 353.7), Muscle (RPKM 232.0) and 9 other tissues See more
Orthologs

Genomic context

See Higd1a in Genome Data Viewer
Location:
8q32
Exon count:
4
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (130482492..130491888, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 8 NC_005107.3 (129660254..129669650, complement)

Chromosome 8 - NC_005107.4Genomic Context describing neighboring genes Neighboring gene hedgehog acyltransferase-like Neighboring gene coiled-coil domain containing 13 Neighboring gene uncharacterized LOC103690474 Neighboring gene atypical chemokine receptor 2

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
cellular response to glucose starvation IEA
Inferred from Electronic Annotation
more info
 
cellular response to glucose starvation ISO
Inferred from Sequence Orthology
more info
PubMed 
cellular response to hypoxia IEA
Inferred from Electronic Annotation
more info
 
cellular response to hypoxia ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
PubMed 
negative regulation of release of cytochrome c from mitochondria IEA
Inferred from Electronic Annotation
more info
 
negative regulation of release of cytochrome c from mitochondria ISO
Inferred from Sequence Orthology
more info
PubMed 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
PubMed 
mitochondrion ISO
Inferred from Sequence Orthology
more info
PubMed 
nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
PubMed 
protein-containing complex IEA
Inferred from Electronic Annotation
more info
 
protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
respiratory chain IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
HIG1 domain family member 1A, mitochondrial
Names
HIG1 domain family, member 1A
hypoxia induced gene 1
hypoxia-inducible gene 1 protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_080902.4NP_543178.2  HIG1 domain family member 1A, mitochondrial

    See identical proteins and their annotated locations for NP_543178.2

    Status: PROVISIONAL

    Source sequence(s)
    BC059118
    UniProtKB/Swiss-Prot
    Q8VH49
    Related
    ENSRNOP00000061362.1, ENSRNOT00000064114.3
    Conserved Domains (1) summary
    pfam04588
    Location:2876
    HIG_1_N; Hypoxia induced protein conserved region

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005107.4 Reference Rnor_6.0 Primary Assembly

    Range
    130482492..130491888 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Rn_Celera

Genomic

  1. AC_000076.1 Alternate Rn_Celera

    Range
    120638935..120648165 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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