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Il2rg interleukin 2 receptor subunit gamma [ Rattus norvegicus (Norway rat) ]

Gene ID: 140924, updated on 30-Jun-2020

Summary

Official Symbol
Il2rgprovided by RGD
Official Full Name
interleukin 2 receptor subunit gammaprovided by RGD
Primary source
RGD:621466
See related
Ensembl:ENSRNOG00000003954
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Cd132; Ab2-183
Summary
cytokine receptor which contributes to ligand binding and signal transduction [RGD, Feb 2006]
Expression
Biased expression in Thymus (RPKM 646.5), Spleen (RPKM 370.5) and 4 other tissues See more
Orthologs

Genomic context

See Il2rg in Genome Data Viewer
Location:
Xq22
Exon count:
8
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (71165378..71169078, complement)
106 current Rn_Celera (GCF_000002265.2) X AC_000089.1 (66751239..66754899, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) X NC_005120.3 (72017856..72021516, complement)

Chromosome X - NC_005120.4Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102548326 Neighboring gene forkhead box O4 Neighboring gene chromosome X open reading frame, human CXorf65 Neighboring gene mediator complex subunit 12 Neighboring gene neuroligin 3

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
cytokine binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytokine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
interleukin-15 receptor activity ISO
Inferred from Sequence Orthology
more info
 
interleukin-2 binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
cytokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
interleukin-15-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of B cell differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of T cell differentiation in thymus ISO
Inferred from Sequence Orthology
more info
 
positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
positive regulation of lymphocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of phagocytosis ISO
Inferred from Sequence Orthology
more info
 
regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cell surface ISO
Inferred from Sequence Orthology
more info
 
external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
cytokine receptor common subunit gamma
Names
interleukin 2 receptor, gamma (severe combined immunodeficiency)

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_080889.1NP_543165.1  cytokine receptor common subunit gamma precursor

    See identical proteins and their annotated locations for NP_543165.1

    Status: PROVISIONAL

    Source sequence(s)
    BC079343
    UniProtKB/TrEMBL
    Q68FU6
    Related
    ENSRNOP00000005343.4, ENSRNOT00000005343.7
    Conserved Domains (2) summary
    cd00063
    Location:154246
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl21522
    Location:59151
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005120.4 Reference Rnor_6.0 Primary Assembly

    Range
    71165378..71169078 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017601899.1XP_017457388.1  cytokine receptor common subunit gamma isoform X1

Alternate Rn_Celera

Genomic

  1. AC_000089.1 Alternate Rn_Celera

    Range
    66751239..66754899 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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